Registration Dossier
Registration Dossier
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EC number: 203-312-7 | CAS number: 105-59-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 21 -d NOEC was determined to be 13.9 mg/L (BASF SE, 2021)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 13.9 mg/L
Additional information
The assessment was performed with the QSAR Toolbox v4.4 calculation model. The 21 -d NOEC was determined to be 13.9 mg/L (BASF SE, 2021). The substance was within the applicability domain of the model. The calculation was performed with the trend analysis method and the substance was within the applicability domain of the calculation models.
Overall, it can be concluded, that that long-term effects are not to be expected.
Furthermore, a 96 -hour reproduction test on the marine copepod Acartia tonsa was performed (TNO Chemistry, 2002). The 96 -h NOEC was determined to be >= 100 mg/L. The 96 -h LC50 for parental mortality was > 100 mg/L. Although this study aimed to test the effect of MDEA on Acartia tonsa, there are several shortcomings of the test design to yield valid information on reproduction. A valid reproduction test should start with the exposure of newly hatched larvae, which should have sufficient time to reach adulthood and produce 2 to 3 broods of offspring in the control assays. As this study used 12 -d old females and information on the number of broods is missing, information regarding reproduction should not be considered in the risk assessment of MDEA. The data on mortality are discussed in IUCLID Ch. 6.1.3 Short-term toxicity to aquatic invertebrates.
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