Registration Dossier
Registration Dossier
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EC number: 231-831-9 | CAS number: 7758-05-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for "Skin Sensitisation" read across evaluation for 7758-05-6
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR toolbox v 2.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Not Available
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- Potassium iodate
- EC Number:
- 231-831-9
- EC Name:
- Potassium iodate
- Cas Number:
- 7758-05-6
- Molecular formula:
- HIO3.K
- IUPAC Name:
- potassium iodate
- Details on test material:
- SMILES:O=I(=O)O{-}.K{+}
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Strain:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: no data
Results and discussion
- Positive control results:
- the results shows KIO3 is positive sensitizer
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- Concentrations ranging from 5 to 20 % in petrolatum
- No. with + reactions:
- 3
- Total no. in group:
- 8
- Clinical observations:
- Infive of eight patients, the reaction were negative
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: Concentrations ranging from 5 to 20 % in petrolatum. No with. + reactions: 3.0. Total no. in groups: 8.0. Clinical observations: Infive of eight patients, the reaction were negative.
Any other information on results incl. tables
The
prediction was based on dataset comprised from the following
descriptors: "Skin Sensitisation"
Estimation method: Taking highest mode value from the 5 nearest
neighbours
("a"
and "b" )
Domain
logical expression index: "a"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 0.0436
Domain
logical expression index: "b"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 0.0436
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Executive summary:
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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