Registration Dossier
Registration Dossier
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EC number: 231-831-9 | CAS number: 7758-05-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicology of Iodate : A Review of the Literature
- Author:
- H. Burgi, Th. Schaffner and J.P. Seiler
- Year:
- 2 001
- Bibliographic source:
- THYROID Volume 11, Number 5, 2011; Mary Ann Liebert, Inc. 2001
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium iodate
- EC Number:
- 231-831-9
- EC Name:
- Potassium iodate
- Cas Number:
- 7758-05-6
- Molecular formula:
- HIO3.K
- IUPAC Name:
- potassium iodate
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- dog
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: geletin capsules
Doses / concentrations
- Remarks:
- Doses / Concentrations:
200 mg/kg
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Iodate is rapidly absorbed and extensively distributed. It is metabolised via a non-enzymatic process, with a proportion of the available iodate converted to iodine. Iodate is excreted via the kidneys.
Radiolabel was absorbed rapidly into aqueous and vitreous humours of the eye (time unknown). Any radiolabel remaining in blood persisted for many hours and was gradually reduced by the liver to iodide. - Details on distribution in tissues:
- Rats and rabbits (strain unknown) were administered 0.75-1 μg iodine via the oral route or intraperitoneally. Radioiodine was extensively distributed and found in the liver, kidney, brain, heart, muscle, small intestine, stomach, testes, submaxillary gland, skin, hair and thyroid (values unknown). Tissue distribution was the same for both iodine and iodate
- Details on excretion:
- when dogs were fed a dose of 200 mg/kg of potassium iodate in the form of gelatin capsules, their urine containes iodide as well as iodate
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- iodide and iodate
Applicant's summary and conclusion
- Conclusions:
- when dogs were fed a dose of 200 mg/kg of potassium iodate in the form of gelatin capsules, their urine containes iodide as well as iodate
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