Potassium iodate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

RTECS Number : NN1350000

Year:

2012

Bibliographic source:

RTECS (Registry of Toxic Effects of Chemical Substances) -;The toxicology of potassium and sodium iodates: acute toxicity in mice. Journal of Pharmacology and Experimental Therapeutics. V.1- 1909/10: 120,171,1957"

Reference 2

Reference Type:

review article or handbook

Title:

DPIM: PLK250

Author:

Richard J. Lewis, Sr.

Year:

2007

Bibliographic source:

SAX (Sax's Handbook of Dangerous Industrial Materials); The toxicology of potassium and sodium iodates: acute toxicity in mice. Journal of Pharmacology and Experimental Therapeutics. 120 (1957), 171 "

Reference 3

Reference Type:

other: Authoritative data base

Title:

GCID 457955

Year:

2011

Bibliographic source:

ACToR (Aggregated Computational Toxicology Resource); Journal of Pharmacology and Experimental Therapeutics. Vol. 120, Pg. 171, 1957

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Principles of method if other than guideline:

Single-dose, acute toxicity experiments

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Potassium iodate

EC Number:

231-831-9

EC Name:

Potassium iodate

Cas Number:

7758-05-6

Molecular formula:

HIO3.K

IUPAC Name:

potassium iodate

Test animals

Species:

mouse

Strain:

Swiss

Sex:

male/female

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

unchanged (no vehicle)

Doses:

531 mg/kg

No. of animals per sex per dose:

No data

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LDLo

Effect level:

531 mg/kg bw

Based on:

test mat.

Remarks on result:

other: other details not available

Mortality:

Lethal dose

Clinical signs:

other: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - hypermotility, diarrhea

Applicant's summary and conclusion

Conclusions:

Acute toxicity : oral is examined at dose concentration of 531 mg/kg.

Executive summary:

Abstract

Single-dose, acute toxicity experiments,

carried out with white Swiss mice, using potassium and sodium iodates and the corresponding iodides, led to the following conclusions:

Administered in sufficient quantities, the iodates cause intoxication and death. In some instances, death is attributed to renal damage with retention of non-protein nitrogen. Hemolytic effects are evidenced by hemoglobinuria and, histologically, by hemoglobin casts and hemosiderin deposits in the kidneys.

Fatty visceral changes, non-specific in nature, appear within 24 hours after ingestion of iodates or iodides. Similar changes occur in fasted animals.

Oral administration of iodates, at levels of 140 to 500 mgm./kgm., often increase the pH of the gastric contents. This is frequently accompanie by degenerative changes in the parietal cells. The damage is transient, as evidenced by restoration to normal in histological appearance of the gastric mucosa and in the pH values after 24 hours. Intraperitoneal and intravenous injections of iodates have little effect on the gastric pH.

The toxicity of potassium iodate varies greatly with the route of administration; the oral LD₅₀for mice fasted on sawdust overnight is six times that of the intraperitoneal LD₅₀. Potassium iodate and sodium iodate have nearly identical oral toxicities and similar intraperitoneal toxicities; the oral toxicity of the potassium compound is nearly the same for heavy and light mice and for both sexes, and is not increased in weanling animals.

Similarly, the relative toxicities of iodates and iodides depend on route of administration and on previous treatment of the mice.