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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study report which meets basic scientific principles of a subacute oral toxicity test. Screening study with limited documentation. Especially, effects not described if primary or secondary to corrosiveness.

Data source

Reference
Reference Type:
other: TSCATS
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Screening study with an exposure period of 2 work weeks.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methanesulphonyl chloride
EC Number:
204-706-1
EC Name:
Methanesulphonyl chloride
Cas Number:
124-63-0
Molecular formula:
CH3ClO2S
IUPAC Name:
methanesulfonyl chloride
Details on test material:
- Name of test material (as cited in study report): methanesulfonyl chloride

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
2 work weeks
Frequency of treatment:
one dose daily
Doses / concentrations
Remarks:
Doses / Concentrations:
50, 100 mg/kg bw
Basis:
actual ingested
No. of animals per sex per dose:
5 animals per dose

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Mortality:
mortality observed, treatment-related
Body weight and weight changes:
effects observed, treatment-related
Food consumption and compound intake (if feeding study):
effects observed, treatment-related
Water consumption and compound intake (if drinking water study):
effects observed, treatment-related
Haematological findings:
effects observed, treatment-related
Clinical biochemistry findings:
effects observed, treatment-related
Organ weight findings including organ / body weight ratios:
effects observed, treatment-related
Gross pathological findings:
effects observed, treatment-related
Details on results:
Three of the five animals given 100 mg/kg died within six days. The remianing two were discarded. All animals developed discoloured, green urine.
Gross examination of the 100 mg/kg group shoved cytotoxicity to the mucosal surfaces of the gastrointestinal tract. Repeated doses resulted in perforation of the wall of the gastrointestinal tract and adhesions to adjacent viscera. Toxic hepatitis was also noted in all 100 mg/kg treated animals survivirg 24 hours. Anemia was present clinically as a loss of color to the eyes and skin.

Effect levels

Dose descriptor:
LOAEL
Effect level:
50 mg/kg bw/day (nominal)
Based on:
test mat.
Basis for effect level:
other: see 'Remark'

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Regarding the results of the subacute oral toxicity study with rats, the test substance methanesulfonyl chloride can be described as a severe tissue irritant. Especially effects are not described if primary or secondary to corrosiveness. Thus, classification is not possible to justify.