Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-706-1 | CAS number: 124-63-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In a test performed according to the maximization method of Magnusson and Kligman, the OECD guideline #406 and the GLP (Manciaux, 2003), methanesulfonyl chloride (purity 99.9%) was administered to guinea pigs at the concentrations of 2 mg/ml intracutaneously and 200 mg/ml in paraffin oil under an occlusive patch.
The challenge concentration of 200 mg/ml under an occlusive patch induced delayed contact hypersensitivity in 20/20 (100%) guinea-pigs. Methanesulfonyl chloride was considered as a strong skin sensitizer.
Justification for classification or non-classification
Self-classification according to:
- Directive 67/548/EEC
R43.
- Regulation (EC) No 1272/2008
Skin sensitization, category 1
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
