Registration Dossier
Registration Dossier
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EC number: 204-706-1 | CAS number: 124-63-0
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Human patch test - no guideline available.
Data source
Reference
- Reference Type:
- other: case study
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Patch tests were performed with ICDRG routine batteries with 10 test persons.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methanesulphonyl chloride
- EC Number:
- 204-706-1
- EC Name:
- Methanesulphonyl chloride
- Cas Number:
- 124-63-0
- Molecular formula:
- CH3ClO2S
- IUPAC Name:
- methanesulfonyl chloride
- Details on test material:
- - Name of test material (as cited in study report): mesylchloride (MSC)
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Route of administration:
- dermal
Results and discussion
Any other information on results incl. tables
After 48 and 72h, a strong positive reaction was obtained to 1% MSC (in pet.). 6 weeks after this test, the patients were retested with MSC in lower concentrations: 0.5%, 0.2%, 0.1% (all in pet.). To MSC, a positive papulovesicular reaction was seen when tested with 0.5% and 0.2%, lower concentrations were negative.
Applicant's summary and conclusion
- Conclusions:
- Regarding the results of the patch test on humans, the test substance methanesulphonyl chloride is not senisitzing to the human skin, but could probably be irritant.
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