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EC number: 203-475-4 | CAS number: 107-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 24.2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 815 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Not necessary; repeated dose toxicity study by inhalation is available.
- AF for dose response relationship:
- 1
- Justification:
- Default value
- AF for differences in duration of exposure:
- 6
- Justification:
- Default AF for time extrapolation from subacute to chronic exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling was already considered when calculating the starting point (NOAEC).
- AF for other interspecies differences:
- 2.5
- Justification:
- Default AF for other interspecies differences.
- AF for intraspecies differences:
- 5
- Justification:
- The default AF for the group "worker" is used.
- AF for the quality of the whole database:
- 1
- Justification:
- The quality of the whole data base is considered to be sufficient and uncritical.
- AF for remaining uncertainties:
- 1
- Justification:
- Default value
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 339 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Dose descriptor:
- NOAEC
- AF for dose response relationship:
- 1
- Justification:
- Default value
- AF for differences in duration of exposure:
- 1
- Justification:
- Not applicable in the case of local effects.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling was already considered when calculating the starting point (NOAEC)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default AF for other interspecies differences.
- AF for intraspecies differences:
- 5
- Justification:
- The default AF for the group "worker" is used.
- AF for the quality of the whole database:
- 1
- Justification:
- The quality of the whole data base is considered to be sufficient and uncritical.
- AF for remaining uncertainties:
- 1
- Justification:
- Default value
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Derivation of worker DNELs for methyl vinyl ether (MVE)
General remarks
A category aproach (OECD SIDS 2006) is available for vinyl ethers: methyl vinyl ether (MVE; CAS 107-25-5), ethyl vinyl ether (EVE, CAS 109-92-2), and isobutyl vinyl ether (IBVE, CAS 109-53-5) (see chapter 13).
Data on acute oral toxicity of MVE are not available (study technically not feasable; low boiling point). In acute inhalation studies in rats the LC50 (4h) was > 20165 ppm (48 mg/L). The LD50 in acute dermal toxicity studies with cold liquid in rabbits was >5000 mg/kg bw.
Cold liquid MVE (boiling point 6°C; gaseous at room temperature)
was not irritant to the skin and only slightly irritant to the eye.
Data on sensitisation are not available.
In subacute inhalation studies with MVE the NOAEC for male rats was 1500 ppm (3.6 mg/L) and the LOAEC is 3500 ppm (8.4 mg/L) due to systemic effects. In female rats the NOAEC was 3500 ppm (8.4 mg/L) due to local effects on the olfactory epithelium, clinical signs and reduced body weight at 25000 ppm (60 mg/L).
Mutagenicity and carcinogenicity: No gene mutagenic activity of MVE was detected in the Salmonella microsome assay and HPRT assay. No clastogenic or aneugenic effects were recorded in the mouse micronucleus test. Data on carcinogenic activity are not available.
In a developmental toxicity study with MVE according to OECD TG 414 the LOAEC for maternal toxicity was 5000 ppm or 12 mg/L (lowest dose tested). At this dose level no adverse developmental effects were noted (NOEC). The NOAEC for teratogenic effects was 19500 ppm or 47 mg/L.
DNEL acute toxicity
MVE is not classified for acute toxicity. Thus, a DNEL for acute toxicity was not considered.
Worker-DNEL long-term for inhalation route-systemic
Description |
Value |
Remark |
Step 1) Relevant dose-descriptor |
NOAEC: 3613 mg/m³ |
(OECD 412; inhal; rat) |
Step 2) modification of the starting point |
|
|
|
6 h/8 h |
to 8 h exposure |
|
6.7 m³/10 m³ |
to light work |
Step 3) Assessment factors |
|
|
Exposure duration |
6 |
subacute/chronic |
Interspecies |
1 |
No interspecies extrapolation for Inhal. |
Intraspecies |
5 |
worker |
Remaining differences |
2.5 |
|
DNEL |
Value |
|
For workers |
3613 x 0.75 x 0.67 / (6 x 1 x 5 x 2.5) = 24.2 mg/m³ |
Worker-DNEL long-term for dermal route-systemic and local
At room temperature, MVE is an extremely flammable gas and may generate explosive atmospheres. Worker exposure is controlled by the use of closed systems, industrial hygiene controls, and personal protective equipment (OECD SIDS 2006). No exposure expected and therefore no DNEL derived.
Worker-DNEL long-term for inhalation route-local
Description |
Value |
Remark |
Step 1) Relevant dose-descriptor |
NOAEC 8431 mg/m³ (OECD 412; inhal; rat) |
Local effects on the olfactory epithelium |
Step 2) modification of the starting point |
|
|
|
6 h/8 h |
to 8 h exposure |
|
6.7 m³/10 m³ |
to light work |
Step 3) Assessment factors |
|
|
Exposure duration |
1 |
Local effects |
Interspecies |
1 |
no interspecies extrapolation for Inhal. |
Intraspecies |
5 |
worker |
Remaining differences |
2.5 |
|
DNEL |
Value |
|
For workers |
8431 x 0.75 x 0.67 / (1 x 1 x 5 x 2.5) = 339 mg/m³ |
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 903 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Not necessary; repeated dose toxicity study by inhalation is available.
- AF for dose response relationship:
- 1
- Justification:
- Default value
- AF for differences in duration of exposure:
- 6
- Justification:
- Default AF for time extrapolation from subacute to chronic exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling was already considered when calculating the starting point (NOAEC).
- AF for other interspecies differences:
- 2.5
- Justification:
- Recommended AF for other interspecies differences.
- AF for intraspecies differences:
- 10
- Justification:
- The default AF for the group "general population" is used.
- AF for the quality of the whole database:
- 1
- Justification:
- The quality of the whole data base is considered to be sufficient and uncritical.
- AF for remaining uncertainties:
- 1
- Justification:
- Default value
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 84 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor:
- NOAEC
- AF for dose response relationship:
- 1
- Justification:
- Default value
- AF for differences in duration of exposure:
- 1
- Justification:
- Not applicable in the case of local effects.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling was already considered when calculating the starting point
- AF for other interspecies differences:
- 2.5
- Justification:
- Recommended AF for other interspecies differences.
- AF for intraspecies differences:
- 10
- Justification:
- The default AF for the group "general population" is used.
- AF for the quality of the whole database:
- 1
- Justification:
- The quality of the whole data base is considered to be sufficient and uncritical.
- AF for remaining uncertainties:
- 1
- Justification:
- Default value
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Derivation of consumer DNELs for methyl vinyl ether (MVE)
General remarks
See section "Workers".
DNEL acute toxicity
MVE is not classified for acute toxicity. Thus, a DNEL for acute toxicity was not considered.
General population-DNEL long-term for oral route-systemic
Consumer exposure to residual MVE is considered to be very low (see OECD SIDS 2006). Physico-chemical properties suggested no oral exposure. Thus, a DNEL for oral exposure was not considered.
General population -DNEL long-term for inhalation route-systemic
Description |
Value |
Remark |
Step 1) Relevant dose-descriptor |
NOAEC: 3613 mg/m³ |
OECD 412; inhal; rat |
Step 2) modification of the starting point |
|
|
|
6h / 24 h |
to 24h exposure) |
|
1 |
No adoption to light work for consumers |
Step 3) Assessment factors |
|
|
Exposure duration |
6 |
subacute/chronic |
Interspecies |
1 |
No interspecies extrapolation for Inhal. |
Intraspecies |
10 |
consumer |
Remaining differences |
2.5 |
|
DNEL |
Value |
|
For consumer |
3613 x 0.25 x 1 / (6 x 1 x 10 x 2.5) = 6 mg/m³ |
General population -DNEL long-term for dermal route-systemic + local
MVE is practically exclusively used as intermediate in the manufacture of vinyl ether polymers and co-polymers. Potentially existing residual MVE is expected to evaporate during the process of heat-treatment (OECD SIDS 2006). No dermal exposure of general population expected. Thus, no DNEL was considered.
General population-DNEL long-term for inhalation route-local
Description |
Value |
Remark |
Step 1) Relevant dose-descriptor |
NOAEC 8431 mg/m³ (OECD 412; inhal; rat) |
Local effects on the olfactory epithelium |
Step 2) modification of the starting point |
|
|
|
6h / 24 h |
to 24h exposure |
|
1 |
No adoption to light work for consumers |
Step 3) Assessment factors |
|
|
Exposure duration |
1 |
local effects |
Interspecies |
1 |
No interspecies extrapolation for Inhal. |
Intraspecies |
10 |
consumer |
Remaining differences |
2.5 |
|
DNEL |
Value |
|
For consumer |
8431 x 0.25 x 1 / (1 x 1 x 10 x 2.5) = 84 mg/m³ |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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