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EC number: 203-291-4 | CAS number: 105-37-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-01-12 to 2015-01-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 19 g/L
- Loading of aqueous phase:
- 250 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- 4.4
- Details on results:
- Preliminary Test (nonGLP): The determined solubility was in the range of 20 - 50 g/L.
- Conclusions:
- The water solubility of the test item was determined to be 19.0 g/L (pH 4.4) at 20 ± 0.5 °C.
- Executive summary:
The test item has a water solubility of 19.0 g/L (pH 4.4) at 20 ± 0.5 °C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).
Reference
Water solubility results at 20°C for the test item
Preincubation time |
Replicate No. |
test item |
|
Concentration1) |
Mean |
||
24 h |
1 |
19.2 |
19.1 |
2 |
19.0 |
||
48 h |
1 |
19.2 |
19.2 |
2 |
19.2 |
||
72 h |
1 |
19.2 |
18.8 |
2 |
18.5 |
||
Mean (24-72 h) |
|
19.0 |
|
Deviation [%](24-72) |
1.9 |
||
1) Mean value of double injections
Check of temperature:
Temperature at incubation phase, 30°C and thermostatisation phase, 20°C (measured hourly)
Intended temperature [°C] |
Measured temperature [°C] |
||
|
Min |
Max |
Mean value ± SD |
30.0 ± 0.5 |
29.62 |
30.09 |
30.03 ± 0.06 |
20.0 ± 0.5 |
19.96 |
20.21 |
20.04 ± 0.06 |
Check of pH value of the test mixture
Test temperature [°C] |
Preincubation time [h] |
Replicate |
Measured pH |
Mean value |
20 |
24 |
1 |
4.501 |
4.4 |
2 |
4.343 |
|||
48 |
1 |
4.444 |
||
2 |
4.457 |
|||
72 |
1 |
4.304 |
||
2 |
4.471 |
|||
|
Control |
6.818 |
- |
No tyndall effect was detected during the incubation time.
Validity criteria were fulfilled: The concentration measured did not differ more than 15%, temperatures were kept constant within ± 0.5°C.
Description of key information
The water solubility is 19.0 g/L (pH 4.4) at 20±0.5°C.
Key value for chemical safety assessment
- Water solubility:
- 19 g/L
- at the temperature of:
- 20 °C
Additional information
The test item has a water solubility of 19.0 g/L (pH 4.4) at 20±0.5°C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).
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