Registration Dossier
Registration Dossier
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EC number: 500-734-6 | CAS number: 162492-01-5
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.1 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 1 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.01 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 0.1 mg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 3.493 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 5.734 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.573 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 1.088 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential to cause toxic effects if accumulated (in higher organisms) via the food chain
Additional information
Conclusion on classification
Environmental fate and pathways
Degradation
Not readily biodegradable (-0.1% in 28 d, OECD 301 B)
Bioaccumulation
log Kow = 4.23 (20 °C, OECD 117, HPLC method)
Aquatic acute toxicity
Fish
LL50 (96 h) > 100 mg/L (nominal, OECD 203, D. rerio)
Aquatic invertebrates
EL50 (48 h) > 100 mg/L (nominal, OECD 202, D. magna)
Aquatic algae
EL50 (72 h) > 100 mg/L (nominal, OECD 201, P. subcapitata)
Aquatic chronic toxicity
Aquatic algae
EL10 (72 h) > 100 mg/L (nominal, OECD 201, P. subcapitata)
Classification according to CLP
Hexamethylene diisocyanate, trimers, reaction products with 2-hydroxyethyl acrylate (CAS 162492-01-5) is not rapidly degradable and has a log Pow > 4.0. No short-term toxicity to aquatic organisms of all three trophic levels (fish, aquatic invertebrates and algae) nor long-term toxicity to aquatic algae was observed up to the limit of water solubility of the substance (< 0.54 mg/L, 20 °C, OECD 105). Based on the available data compiled above, Hexamethylene diisocyanate, trimers, reaction products with 2-hydroxyethyl acrylate (CAS 162492-01-5) is classified and labelled as chronic 4 (´safety net´ classification) for environmental hazards, according to the consolidated version of Regulation (EC) No 1272/2008 (dated: 01.01.2017) and further amendments (ATPs).
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