Sulphoacetic acid

Endpoint summary

Description of key information

Acute oral toxicity study was done in rat using sulfoacetic acid (123-43-3). LD50 was considered to be 3160 mg/kg body weight.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from chemidplus and GSBL database.

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Acute oral toxicity study of Sulfoacetic acid was performed in Rat

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Specific details on test material used for the study:

- Name of test material : Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight : 140.115g/mole
- Substance type:organic
- Physical state:solid

Species:

rat

Strain:

Sherman

Sex:

not specified

Details on test animals or test system and environmental conditions:

- Fasting period before study: Rats were no fasted before experiment.

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

No data available

Doses:

3160 mg/kg

No. of animals per sex per dose:

5 animal /dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

The LD 50 was derived from the course of the curve mortality versus log of the dose graphically determined.

Sex:

not specified

Dose descriptor:

LD50

Effect level:

3 160 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50 % mortality observed

Mortality:

Mortality observed

Clinical signs:

other: No data available

Gross pathology:

No data available

Other findings:

No data available

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

Acute oral toxicity study was done in rat using sulfoacetic acid (123-43-3). LD50 was considered to be 3160 mg/kg body weight.

Executive summary:

Acute oral toxicity test was performed in Sherman rats and observed for 14 days. No fasting of rats was done before experiment. 5 animals per dose were given dose by gavage and LD50 was derived from the course of the curve mortality versus log of the Dose graphically determined. After the experiment, the LD 50 value for sulfoacetic acid (123-43-3) was considered to be 3160 mg/kg.

Based on the value, sulfoacetic acid was considered to be non-toxic to rats and can be considered to be “not classified”as per the CLP regulations.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

3 160 mg/kg bw

Quality of whole database:

Data is Klimicsh 2 and from chemidplus and GSBL database

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Acute oral toxicity

In different studies, sulfoacetic acid (123-43-3).has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for sulfoacetic acid. The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

In experimental study given by U.S. National Library of Medicine (ChemIDplus A TOXNET Database, 2017) and GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States, 2017. Acute oral toxicity test was performed in Sherman rats and observed for 14 days. No fasting of rats was done before experiment. 5 animals per dose were given dose by gavage and LD50 was derived from the course of the curve mortality versus log of the Dose graphically determined. After the experiment, the LD 50 value for sulfoacetic acid (123-43-3) was considered to be 3160 mg/kg.

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for sulfoacetic acid. The LD50 was estimated to be 3160 mg/kg bw when Sprague-Dawley male and female rats were orally exposed with sulfoacetic acid

In another prediction done by SSS (2017) using the Danish QSAR with log kow as the primary descriptor, the acute oral toxicity was estimated for sulfoacetic acid. The LD50 was estimated to be 3800 mg/kg bw in rats (Reliability index: 0.77) orally exposed with sulfoacetic acid.

 

Also it is further supported by experimental study given by U.S. National Library of Medicine (ChemIDplus A TOXNET Database, 2017) on structurally similar read across substance Propionic acid(79 -09 -4), rats were treated with Propionic acid orally. 50% mortality was observed in treated mice at 2600 mg/kg bw. Therefore, LD50 was considered to be 2600mg/kg bw when rats were treated with Propionic acid orally.   

Also it is further supported by experimental study given by U.S. National Library of Medicine (ChemIDplus A TOXNET Database, 2017) on structurally similar read across substance adipic acid(124-04-9)rats were treated with adipic acid orally. No mortality was observed in treated mice at 11000 mg/kg bw. Therefore, LD50 was considered to be > 11000mg/kg bw when rats were treated with adipic acid(124-04-9)orally

 

Thus, based on the above studies and predictions on sulfoacetic acid (123-43-3) and its read across substances, it can be concluded that LD50 value is 3160mg/kg bw. Thus, comparing this value with the criteria of CLP regulation sulfoacetic acid (123-43-3)can be “Not classified” of acute oral toxicity.

 

Justification for classification or non-classification

Thus, based on the above studies and predictions on sulfoacetic acid (123-43-3) and its read across substances, it can be concluded that LD50 value is 3160mg/kg bw. Thus, comparing this value with the criteria of CLP regulation sulfoacetic acid (123-43-3)can be “Not classified” of acute oral toxicity.