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EC number: 210-459-0 | CAS number: 616-02-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance tested full strength by application of 0.01ml of undiluted sample to an area upon the clipped belly of an albino rabbit caused severe injury like that caused by morpholine (no further data).
The substance is corrosive to the eye according to the Draize scoring method: Corneal involvement, irritation or eye damage that persists for more than 21 days after treatment.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited publication
- Principles of method if other than guideline:
- no information
- Species:
- rabbit
- Interpretation of results:
- Category 1 (corrosive)
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Citraconic acid anhydride tested full strength by application of 0.01ml of undiluted sample to an area upon the clipped belly of an albino rabbit caused severe injury like that caused by morpholine (no further data).
- Executive summary:
Citraconic acid anhydride tested full strength by application of 0.01ml of undiluted sample to an area upon the clipped belly of an albino rabbit caused severe injury like that caused by morpholine (no further data).
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to methods similar to OECD 405, not accoring to GLP. Details on test substance and results are limited.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: Japanese white rabbits
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Takeo breeder NII-Electronic Library Service
- Age at study initiation: no data
- Weight at study initiation: 2.0-2.2 kg
- Housing:housed in metal cages (39 X 40 X 44 cm)
- Diet (e.g. ad libitum): fed the RC4 diet (Oriental Yeast Co., Tokyo, Japan), ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):25 ± 1°C
- Humidity (%): 55 ± 5%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: no data - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The right eye was served as a blank.
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- The eyes were examined and the grade of ocular reaction was recorded 1, 4, 24, 48, 72, 96hr, 7, 14 and 21 days after the treatment of chemicals.
- Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE: none
SCORING SYSTEM: Corneal opacity, erythema, chemosis, secreta and iritis were classified according to the Draize score
TOOL USED TO ASSESS SCORE: no data - Irritation parameter:
- other:
- Basis:
- other: all animals
- Time point:
- other: up to 21 days
- Reversibility:
- not reversible
- Remarks on result:
- other: Score III: Corrosive
- Irritant / corrosive response data:
- The only data given is that the outcome of the test is corrosive for this test substance. This is confirmed by a QSAR.
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test substance is corrosive to the eye according to the Draize scoring method: Corneal involvement, irritation or eye damage that persists for more than 21 days after treatment.
- Executive summary:
The test substance is corrosive to the eye according to the Draize scoring method: Corneal involvement, irritation or eye damage that persists for more than 21 days after treatment.
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for selection of skin irritation / corrosion endpoint:
No valid data available. K4: Limited publication
Justification for selection of eye irritation endpoint:
K2: The study was performed according to methods similar to OECD
405, not accoring to GLP. Details on test substance and results are
limited.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the available data the substance is classified cat.1 (irreversible effects on the eye) for the eye and Cat. 1B (corrosive) for skin.
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