Registration Dossier
Registration Dossier
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EC number: 700-422-1 | CAS number: 61320-65-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Ames test
Diazokomponente Rot B was investigated using the Salmonella/microsome test according to OECD TG 471 using TA1535, TA100, TA1537, TA98 and TA 102 in the presence and in the absence of a metabolic activation system. Initially the plate incorporation methodology was used and concentrations up to and including 5000 µg/plate. Due to precipitation at 5000 µg/plate the following preincubation methodoloy was done with concentrations up to and including 2000 µg/tube showing predipitation from 1000 µg/tube onwareds. Evidence of mutagenic activity of Diazokomponente Rot B was not seen. No biologically relevant increase in the mutant count in comparison th the negative controls was observed in any of the strains tested with and without S9 -mix in the plate incorporation as well as in the preincubation modification under the experimental conditions applied. The positive controls were functional.
Therefore, Diazokomponente Rot B was considered to be non-mutagenic without and with S9-mix in the plate incorporation as well as in the preincubation modification of the Salmonella / microsme test (Bayer 2011).
Short description of key information:
Diazokomponente Rot B was considered to be non-mutagenic without and with S9-mix in the plate incorporation as well as in the preincubation modification of the Salmonella / microsme test (Bayer 2011).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available data. no classification or labelling has to be required.
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