Registration Dossier
Registration Dossier
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EC number: 203-213-9 | CAS number: 104-55-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Absorption:
Cinnamaldehyde is easy absored within the body rapidly and further distributed in various organs
Distribution:
Radioactivity is distributed primarily to the gastrointestinal tract, kidneys, and liver, after single- or multiple-dose oral administration. At all dose levels, a small amount of the dose is distributed to the fat.
Metabolism:
In the high dose pretreatment group, benzoic acid is the major metabolite, suggesting that saturation of the glycine conjugation pathway occurs at repeated high dose levels of cinnamaldehyde.
Excretion:
After 24 hr, >80% of the radioactivity is recovered in the urine and <7% in the feces from all groups of rats, regardless of dose level.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Absorption:
Cinnamaldehyde is easy absored within the body rapidly and further distributed in various organs
Distribution:
Radioactivity is distributed primarily to the gastrointestinal tract, kidneys, and liver, after single- or multiple-dose oral administration. At all dose levels, a small amount of the dose is distributed to the fat.
Metabolism:
In the high dose pretreatment group, benzoic acid is the major metabolite, suggesting that saturation of the glycine conjugation pathway occurs at repeated high dose levels of cinnamaldehyde.
Excretion:
After 24 hr, >80% of the radioactivity is recovered in the urine and <7% in the feces from all groups of rats, regardless of dose level.
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