Registration Dossier
Registration Dossier
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EC number: 700-102-1 | CAS number: 105112-76-3
Endpoint summary
Administrative data
Description of key information
The acute toxicity of 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline has been studied in the rat for the oral and dermal routes. No information about the acute inhalation toxicity of 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline is available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Both, the oral and dermal acute toxicity studies performed with 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline found LD50 values that were greater than 2000 mg/kg body weight indicating that the substance exhibits low acute toxicity to the rat. Clinical signs including piloerection and depressed body weight gain show that 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline is at least partly systemically available via the oral route and that high volume of the substance may exhibit a certain systemic toxicity. It appears that the availability via the dermal route is negligible.
Justification for classification or non-classification
The substance is not classified as acute toxic by EU-GHS (CLP), since LD50 > 2000 mg/ kg body weight, which is the cut-off in the EU's GHS classification system for acute oral and dermal toxicity.
UN-GHS has a Category 5 for acute oral toxicity for the dose range 2000 mg/kg bw < LD50 < 5000 mg/kg bw, a concentration range which has not been tested. However acute toxicity Category 5 is applied by some authorities only. Furthermore, acc. to GHS 3.1.2.5 testing animals in the Category 5 range is discouraged unless "there is a strong likelyhood that results of such testing would have a direct relevance to the protection of human health", which is not the case.
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