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EC number: 244-617-5
CAS number: 21850-44-2
Acute oral: LD50 > 2000 mg/kgAcute inhalation: LC50> 24.4 mg/L (air)Acute dermal: LD50 > 2000 mg/kg bw
A study was performed to assess the acute oral toxicity of the test
material in Sprague-DawleyCD strain rat. This study followed OECD
guideline 401 (acute oral toxicity). Following a preliminary
range-finding study, a group of 5 males and 5 females was given a single
oral dose of test material as a suspension in arachis oil BP at a dose
level of 2000 mg/kg bodyweight. The animals were observed for 14 days
after the day of dosing and were killed and subjected to gross
There were no deaths, and no signs of systemic toxicity were noted
during the study. All animals showed an expected gain in bodyweight
during the study. No abnormalities were noted at necropsy. LD50 was
found to be greater than 2000 mg/kg bodyweight.
Inhalation exposure of rats for 1 hr to a dust atmosphere of CH-100
-993, 975 -64 at a nominal concentration of 24.4 mg/l resulted in an
increae in respiratory rate during the exposure. No other adverse
effects were observed postexposure. No deaths occured during the
experimental period and the body weight gain of all the rats appeared
Acute dermal toxicity was conducted in Wistar rats using the following
guidelines, OECD 402; Method B3 Acute Toxicity; OPPTS 870.1200.
A group of five males and five females was given a single 24 hr
semi-occluded dermal application at a dose of 2000 mg/kg bodyweight.
clinical signs and bodyweight development were monitored during the
study. All animals were subjected to gross necropsy.
No deaths, no signs of systemic toxicity and no abnormalities were
evident at the end of the experiment.
All animals showed expected gaind in bodyweight and very slight erythema
was noted at the test sites of eight animals.
The test substance was found to be non toxic to rats following the
three acute tests; oral, inhalation and dermal toxicity.
The above results triggered no classification under the EEC criteria for
classification and labelling requirements for Dangerous Substances and
Preparations (67/548/EEC) and the CLP Regulation (EC No 1272/2008).
Therefore, the substance is not classified for acute toxicity.
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