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EC number: 244-617-5
CAS number: 21850-44-2
Studies regarding the absorption, distribution, metabolism, and
excretion of TBBA-DBPE were conducted. Male Fischer-344 rats were dosed
with TBBA-DBPE (20mg/kg) by oral gavage or IV administration. Following
a single oral administration of TBBA-DBPE, elimination of [14C]
equivalents in feces was extensive and rapid (95% by 96 hours).
Following repeated daily oral doses for 5 or 10 days, route and rate of
elimination was similar to single administration of TBBA-DBPE. After IV
administration, fecal excretion of [14C] equivalents was much
slower (27% of dose eliminated by 36h, 71% by 96h). Urinary elimination
was minimal (<0.1%) following oral and IV administration. A single peak
that co-eluted with the standard of TBBA-DBPE was detected in extracts
of whole blood following oral or IV administration. TBBA-DBPE
elimination from the blood was slow. Kinetic constants following IV
dosing were: t1/2b:
24.8h; CLb: 0.1mL/min. Kinetic constants following oral
dosing were: t1/2a:
2.5h:13.9h; CLb :4.6mL/min.
Systemic bioavailability was 2.2%. Liver was the major site of
disposition following oral or IV administration. After oral
administration, 1% of the dose was eliminated in bile in 24h as
metabolites. Inin vitroexperiments utilizing hepatocytes or liver
microsomal protein, no detectable metabolism of TBBA-DBPE occurred.
These data indicate that TBBA-DBPE is poorly absorbed from the
gastrointestinal tract. Compound which is absorbed is sequestered in the
liver, slowly metabolized, and eliminated in the feces.
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