Registration Dossier
Registration Dossier
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EC number: 219-775-3 | CAS number: 2528-61-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound: With high probability acutely not harmful to fish after pH-adjustment.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 100 mg/L
Additional information
Regarding the information requirements of REACH for this tonnage band, a study with fish is not required.
The toxicity of heptanoyl chloride (CAS 2528 -61 -29) to Leuciscus idus was tested according to German Industrial Standard Guideline DIN 38412. The 96 -h LC50 was determined to be 68.1 mg/L (geometric mean, nominal, not neutralized). After pH-adjustment no effects were observed at the highest test concentration of 100 mg/L (BASF 1987; 10F0209/875169). Heptanoyl chloride decomposes rapidly in water to form heptanoic acid and hydrochloric acid. Therefore the test organisms were mainly exposed to the hydrolysis product heptanoic acid. Without pH adjustment at 100 mg/l 100 % inhibition was observed after 0 hours; pH was determined to be in the range of 4.1 to 6.1. This indicates that heptanoic acid causes a pH shift in algal medium. It is the resulting pH that determines the impact of acid on algae as shown with buffered test substance solution. Thus, toxic effects are not due to substance inherent properties but due to a function of the pH.
It can be concluded that heptanoyl chloride is with high probability acutely not harmful to fish after pH adjustment.
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