Registration Dossier
Registration Dossier
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EC number: 219-775-3 | CAS number: 2528-61-2
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound: In contact with water, the substance will hydrolyse
rapidly.
Hydrolysis product heptanoic acid: According to structural properties,
hydrolysis is not expected. Moreover, the substance is readily
biodegradable
Key value for chemical safety assessment
Additional information
Parent compound heptanoyl chloride (CAS 2528 -61 -2):
No experimental data are available for the heptanoyl chloride; therefore, a read-across was performed for this endpoint. Hydrolysis of the source substance pivavoyl chloride was tested in a GLP guideline study following OECD 111 (Safepharm., 2003). In a GLP guideline study following OECD TG 111 the test material has been determined to degrade spontaneously in aqueous media. No rate constant or half-life could be determined experimentally. Pivalic acid was determined as the major hydrolysis product.
For the acid chloride category, which includes heptanoyl chloride (CAS 2528-61-2), hydrolysis is the primary reaction in aqueous systems and has been shown to occur very quickly for all compounds at pH 4 and 0 °C and/or pH 1.2 and 37 °C.(OECD SIDS 'Acid chloride category', 2008). All category members hydrolyse in the presence of water or moisture to form hydrochloric acid (CAS 7647-01-0), carbon dioxide (CAS 124-38-9) and the corresponding organic acid. In the case of heptanoyl chloride the corresponding organic acid is heptanoic acid (CAS 111-14-8) which is considered to be readily biodegradable.
Hydrolysis product heptanoic acid (CAS 111 -14 -8):
According to literature data of Harris (1990), Kollig et al. (1993) and
Boethling & Mackay (2000) hydrolysis of the hydrolysis product is not
expected. Moreover, the substance is readily biodegradable (see IUCLID
Ch. 5.2.1)
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