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EC number: 219-775-3 | CAS number: 2528-61-2
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
As the parent compound rapidly hydrolyses in aqueous systems the assessment of the biodegradability is based on the hydrolysis product heptanoic acid, which is readily biodegradable (according to OECD criteria).
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and, therefore, the endpoint(s) sufficiently covered and suitable for risk assessment.
Assessment
The parent compound heptanoyl chloride (CAS 2528 -61 -2) is rapidly hydrolysed to heptanoic acid, HCl and CO2 (see IUCLID Ch. 5.1.2).
- Heptanoyl chloride:
As the parent compound rapidly hydrolyses in aqueous systems the assessment of the biodegradability is based on the hydrolysis product heptanoic acid.
- Heptanoic acid (CAS 111 -14 -8):
Key study: Höchst (1996): OECD 301A, activated sludge (domestic, non-adapted): removal degree 98.7% after 11 d; readily biodegradable according to OECD criteria, rep. no.: 95-0055-41
Supporting study: BASF SE (2022): CATALOGIC v5.15.2 BOD 28 days MITI (OECD 301 C) v12.17: removal degree 100% after 28 d; readily biodegradable
Based on this result, the hydrolysis product propanol is considered readily biodegradable according to OECD criteria.
In conclusion heptanoyl chloride and its hydrolysis product heptanoic acid can be assessed to be readily biodegradable.
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