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Diss Factsheets
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EC number: 700-580-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- May 12, 1981
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-[(2-aminoethyl)amino]propane-1-sulfonic acid
- Cas Number:
- 14235-54-2
- Molecular formula:
- C5H14N2O3S
- IUPAC Name:
- 3-[(2-aminoethyl)amino]propane-1-sulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): EPS
- Physical state: viscous
- Analytical purity: abt. 99 % (as specified by the sponsor)
- Lot/batch No.: LA 92018 SC
- Storage condition of test material: ambient
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harald Schriever; Kaninchenfarm, 2740 Bremervörde, Neuendamm 88, Germany
- Housing: individual housing (50 x 45 x 40 cm, L x B x H) in a battery of cages, each equipped with a paper roll disposal system
- Diet: ad libitum, Ssniff K - Haltung
- Water: ad libitum, drinking water as for human consumption
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3° C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): artificial lightings (120 lux) from 7.00 a.m. - 7.00 p.m.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: hair clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g of the test article / 6 cm2
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30-60 minutes, 24, 48, 72 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: ca. 6 cm2
- Type of wrap if used: Ypsiplast, which was held in place by non-irritating tape Elastoplast and Stülpa, envelopping the whole of the animal's trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water or an appropriate solvent
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Erythema and Eschar Formation
No erythema .......................................................................................................................................................0
Very slight erythema (barely perceptible) ......................................................................................................1
Well defined erythema .......................................................................................................................................2
Moderate to severe erythema ..........................................................................................................................3
Severe erythema (beef redness) to eschar formation preventing grading of erythema.........................4
Maximum possible: 4
Oedema Formation
No oedema......................................................................................................................................................0
Very slight oedema (barely perceptible) ...................................................................................................1
Slight oedema (edges of area well defined by definite raising) .............................................................2
Moderate oedema (raised approximately 1 mm) .....................................................................................3
Severe oedema (raised more than 1 mm and extending beyond area of exposure) .........................4
Maximum possible: 4
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h after patch removal
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- other: not relevant
- Other effects:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EEC directive 91/325/EEC of March 1,1991
- Executive summary:
The potential of "EPS" was assessed in an acute dermal irritation/corrosion test on 3 albino rabbits. The skin was exposed to the test article for 4 h. Animals were examnied for signes of erythema and oedema at 30 -60 min, 24, 48, 72 h after patch removal.
The mean grades of skin reactions after 24, 48 and 72 h after patch removal were lower than the value classified as irritant by the EEC directive 91/325 EEC of March 1, 1991 and the Gefahrenstoffverordnung (GefStoffV), 1987 (BGBl. I, p. 2721). When applied to the skin, the test article "EPS" may therefore be considered to be non-irritant.
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