Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-219-1 | CAS number: 104-61-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. Substance purity is not mentioned.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- Standard acute method (limit test)
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Nonan-4-olide
- EC Number:
- 203-219-1
- EC Name:
- Nonan-4-olide
- Cas Number:
- 104-61-0
- Molecular formula:
- C9H16O2
- IUPAC Name:
- 5-pentyloxolan-2-one
- Details on test material:
- - Name of test material (as cited in study report): Aldehyde C-18 EOA-76-8
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no details
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- no details
- Duration of exposure:
- Single treatment
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Total animals: 4
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- none
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal died on Day 1
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- Erythema lasted for 24 h
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 of γ-Nonalactone is higher than 5000 mg/kg bw in rabbits therefore it is not classified according to the Directive 67/548/EEC and the Regulation (EC) No. 1272/2008 (CLP).
- Executive summary:
In an acute dermal toxicity (limit test) study, a group of 4 rabbits were administered a single dermal dose of γ-Nonalactone at 5000 mg/kg bw. Animals were then observed for 14 days.
During the observation period, one animal died on Day 1. Erythema lasted for 24 h.
Dermal LD50 > 5000 mg/kg bw.
The dermal LD50 of γ-Nonalactone is higher than 5000 mg/kg bw in rabbits therefore it is not classified according to the Directive 67/548/EEC and the Regulation (EC) No. 1272 /2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
