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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 March 2017 to 08 May 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
0.008 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
7
Details on results:
The test substance was stable in the water solution, with no obvious reaction observed.

The results of the calibration curve for the standard are presented in the table below:

Solutions for calibration curve

Conc. of standard solution (mg/L)

Intensity of standard solution

STD1

1.00

464414.22

STD2

2.00

993498.58

STD3

3.00

1568156.09

STD4

4.00

2105887.33

STD5

5.00

2615996.64

Calibration curve: y = 530775.97x - 35551.09 (r = 0.9996)

The water solubility test results are presented in the table below:

 

20 ± 0.5°C, pH = 7.093

Intensity

Conc. (ppm)

Solubility (g/L)

Mean solubility (g/L)

Day 3-1

1364800.85

2.64

0.00791

 

 

0.00790

Day 3-2

1349532.93

2.61

0.00783

Day 2-1

1356609.71

2.62

0.00787

Day 2-2

1361138.34

2.63

0.00789

Day 1-1

1367221.66

2.64

0.00793

Day 1-2

1371311.88

2.65

0.00795

Conclusions:
The water solubility was determined to be 0.0079 g/L at 20±0.5°C and pH 7.015.
Executive summary:

The determination of the water solubility of the test item was carried out using the flask method, in accordance with OECD 105.

The water solubility was determined to be 0.0079 g/L at 20±0.5 °C and pH 7.015.

Description of key information

0.0079 g/L; OECD 105; Chang, M (2017)

Key value for chemical safety assessment

Water solubility:
0.008 g/L
at the temperature of:
20 °C

Additional information

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