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EC number: 246-186-9
CAS number: 24347-58-8
Well 1 [OD570]
Well 2 [OD570]
Mean [OD570] (Well 1 and
Mean [OD570] blank corr. (Well 1 and
Mean [OD570] of T1 and T2
Tissue viabil.* [%]
rel. viabil. of T1 and T2**
Diff. of viabil. between T1 and T2 [p.p.]
* Tissue viability = [100 × meanOD blank corrected of T1&T2test
item / positve control / negative control]/[meanOD of T1&T2negative
** Relative Tissue viability = [100 × meanOD blank correctedtest
item / positive control / negative control]/[meanOD of T1&T2negative
This in vitro study was
performed to assess the eye irritation potential of 2,3-butanediol
((2R,3R)-rich) by means of the Human Cornea Model Test. The study was
conducted according to OECD 492 (adopted 2018) and in compliance with
GLP. Tissues of the human cornea model EpiOcular™ were treated with 50
μL of the test item, the positive and the negative control. The
viability was measured after 30 min exposure and 2 hours post-incubation.
Since the viability
value of the test item exposed tissues was 85.31% when compared to
negative control and hence did not decrease below 60%, the test item is
not considered to possess an eye irritating potential. This study
results were considered acceptable, because treatment with the positive
control induced a decrease in the mean tissue viability compared with
the negative control to 29.91%. The study was considered reliable and
adequate as part of the hazard assessment of eye irritation.
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