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EC number: 246-186-9
CAS number: 24347-58-8
Body weight gain of male rats is presented in the following table:
Twenty five animals of both sexes were fed either control diet or diet
supplemented with 1,3-butylene glycol at dose levels of 5, 10 or 24% of
the diet (2500, 5000 or 12000 mg/kg bw/d). Treatment with the test item
had no influence on reproduction and lactation parameters for four of
five generations of dams and pups. The pregnancy rate of F1A rats
decreased during five successive mating cycles: no pups were obtained at
the high-dose level group of the fifth series of litters (F2E
generation). Excluding this group, the viability of F2 generation pups
revealed no significant differences between litters or between control
and test groups. Body weight gains of male rats in all four generations
were slightly depressed with an apparent dose relationship. Body weight
gain of females was not affected (Hess et al., 1981).
The study indicates that fertility is not impaired through 1,3 -butylene
glycol exposure up to 10% in diet (5000 mg/kg bw/d).
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