Registration Dossier
Registration Dossier
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EC number: 208-634-1 | CAS number: 536-45-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- The study was conducted before a guideline was adopted.
- Principles of method if other than guideline:
- Two groups of male rats (n = 10) received a single treatment of 3100 or 5000 mg/kg bw orally by gavage. Animals were observed for 14 days after treatment. Mortalities and clinical signs were recorded.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- p-anisic acid
- EC Number:
- 202-818-5
- EC Name:
- p-anisic acid
- Cas Number:
- 100-09-4
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 4-methoxybenzoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Weight at study initiation: 160 - 180 g
- Housing: 5 animals/cage
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Doses:
- 3100 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 5000 mg/kg bw two animals died on day 4. No mortalities occurred at 3100 mg/kg bw.
- Clinical signs:
- At 5000 mg/kg all animals showed clinical signs (diarhoea and increased diuresis). No clinical signs were noted at 3100 mg/kg bw.
- Body weight:
- no data available
- Gross pathology:
- no data available
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study conducted prior to implementation of current guidelines in male rats an LD50 of > 5000 mg/kg bw was derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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