Registration Dossier
Registration Dossier
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EC number: 208-634-1 | CAS number: 536-45-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 March 2017 to 23 May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- -0.53
- Temp.:
- 23 °C
- pH:
- >= 7.04 - <= 7.08
- Conclusions:
- Log Kow is -0.53 at 23 ºC and pH 7 (OECD 107, shake-flask method).
Reference
Results Summary
A summary of the calculated Pow and Log Pow is shown below.
Test Mixture |
Pow |
Log Pow |
Average Pow |
Average Log Pow |
1 |
0.3106 |
-0.5078 |
0.2944 |
-0.5311 |
2 |
0.3099 |
-0.5088 |
||
3 |
0.2947 |
-0.5307 |
||
4 |
0.2953 |
-0.5297 |
||
5 |
0.2775 |
-0.5567 |
||
6 |
0.2782 |
-0.5556 |
The OECD method 107 states that the six determined log Pow values should fall within a range of ± 0.3 units. This criterion is fulfilled and the partition coefficient can be reported as total average over six independent determinations:
Pow = 0.2944
(standard deviation 0.01450)
Log Pow = -0.53
The pH value of the aqueous buffer phases varied between 7.04 and 7.08. The partition coefficient was determined at 23 °C.
Description of key information
Log Kow is -0.53 at 23 ºC and pH 7 (OECD 107, shake-flask method).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.53
- at the temperature of:
- 23 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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