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EC number: 214-290-3 | CAS number: 1119-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2018-05-23 to 2019-
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- > 954 000 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 4.3 - <= 4.6
- Conclusions:
- The water solubility at 20 °C of the test item could be estimated to be: cS > 954 g/L (954000 mg/L).
- Executive summary:
The water solubility was determined according to OECD 105 and Regulation (EC) No. 440/2008 method A.6 using the shake flask method with HPLC analysis. About 47 g test item were weighed into 100 mL glass-stoppered Erlenmeyer flasks (three parallels) according to the estimated solubility based on the preliminary test. After the addition of 50 mL double distilled water, the flasks were stirred at 30 °C for 24, 48 and 72 hours.After stirring at 30 °C the flasks were cooled down to 20 °C and stirred at 20 °C for another 24 h. After this time no remaining solid could be observed in the flasks. The mixture of test item and water was jellylike and could not be stirred anymore. Thus, the centrifugation and subsequent analytical determination (HPLC analysis) of the concentration were inapplicable.The pH of each sample was recorded. The water solubility of the test substance was determined to be 954 g/L at 20 °C (pH = 4.3 – 4.6).
Reference
Preliminary test
The solubility of the test item in water at room temperature was estimated to be > 64.8 g/L and < 172.8 g/L. Therefore, the flask method was performed.
Table 2: Preliminary test for the water solubility
Amount of test item [mg] |
Total volume of added water [mL] |
Ultrasonic bath [min] |
Remark |
103.65 |
0.1 |
-- |
not dissolved |
0.6 |
1 |
not dissolved |
|
1.6 |
2 |
dissolved |
Main test
For the main test three flasks were prepared with an amount of test item and water, and one flask only with water. After 24, 48 and 72 h at 30 °C and further 24 h at 20 °C the mixtures could not be stirred anymore because clear jellylike masses were formed. Since no homogenization of the mass could be assured, no analytical measurements of the masses were performed.
In the main test, about 47.7 g of the test item could be dissolved in 50 mL water (954 g/L). This amount formed a jellylike mass, which could not be stirred anymore.
Description of key information
The water solubility of the test item is 954 g/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 954 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility was determined according to OECD 105 and Regulation (EC) No. 440/2008 method A.6 using the shake flask method with HPLC analysis. About 47 g test item were weighed into 100 mL glass-stoppered Erlenmeyer flasks (three parallels) according to the estimated solubility based on the preliminary test. After the addition of 50 mL double distilled water, the flasks were stirred at 30 °C for 24, 48 and 72 hours. After stirring at 30 °C the flasks were cooled down to 20 °C and stirred at 20 °C for another 24 h. After this time no remaining solid could be observed in the flasks. The mixture of test item and water was jellylike and could not be stirred anymore. Thus, the centrifugation and subsequent analytical determination (HPLC analysis) of the concentration were inapplicable.The pH of each sample was recorded. The water solubility of the test substance was determined to be 954 g/L at 20 °C (pH = 4.3 – 4.6) (reference 4.8-1).
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