Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-030-0 | CAS number: 4170-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral gavage (90 days) resulted in irritancy related effects at 5 mg/kg bw and above in rats. Nasal lesions in the form of acute irritation were observed in females at the 5 mg/kg bw.
Oral feed in rats (14 days) did not result in any systemic or irritancy effects at the highest dose tested (175 mg/kg bw).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 5 mg/kg bw/day
Additional information
Oral gavage (90 days) resulted in irritancy related effects at 5 mg/kg bw and above in rats. Nasal lesions in the form of acute irritation were observed in females at the 5 mg/kg bw. The stomach related effects are attributable to the irritancy potential of crotonaldehyde and are not considered to be systemic effects. The nasal lesions in the form of acute inflammation are more difficult to interpret. Being that the dose was oral gavage the animals would not have been exposed to crotonaldehyde via inhalation (as they would be from food or water adminsitration). It is possible that this is also a local or irritancy effect but without the full study it is not conclusive. Therefore the NOAEL for systemic toxicity (oral, repeated dose ) is 5 mg/kg bw day.
Oral feed in rats (14 days) did not result in any systemic or irritancy effects at the highest dose tested. The NOAEL in this study was 175 mg/kg bw. This study is not of the duration or quality of the oral gavage study.
There are no usable studies to determine a NOAEL/LOAEL for inhalation. The Voronin study repeatedly cited is an abstract only and the findings are not supported in any other study. Not enough data available to judge the applicability of the results. Crotonaldehdye is a highly irritating substance and in acute inhalation study excitation was seen noted often (excitation as in running around the cage, jumping - more than likely due to the irriation rather than any systemic / stimulatory effect). The change in hemoglobin levels is not reported in any other study with crotonaldehyde. This effect could also be attributed to the irritant potential of crotonaldehyde. No gross pathology or histology is available to confirm or explain this finding. No organ weights or other clinical parameters were reported in the abstract. This study is not valid for obtaining any inhalation parameters for crotonaldehyde.
Repeated dose toxicity: via oral route - systemic effects (target organ) respiratory: nose
Justification for classification or non-classification
According to criteria in reguldation (EC) No. 1272/2008, as well as the requirements of Annex VI thereof, the substance is classified as STOT RE Cat 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.