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Diss Factsheets
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EC number: 224-030-0 | CAS number: 4170-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Acceptable (pre-GLP; pre-guidelines), study containing basic data which suggests that basic scientific principles have been met. This is sufficient to judge the results reliable as a contribution to the understanding of the toxicity of this substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 950
Materials and methods
- Principles of method if other than guideline:
- other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Crotonaldehyde
- EC Number:
- 224-030-0
- EC Name:
- Crotonaldehyde
- Cas Number:
- 4170-30-3
- Molecular formula:
- C4H6O
- IUPAC Name:
- but-2-enal
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Subcutaneous injections of aqueous solutions of crotonaldehyde at 10% concentration were applied to the rats and 1% to the mice. Animals were observed for 21 days.
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- water
- Details on exposure:
- A single exposure was applied.
- Doses:
- 0.1 - 0.18 g/kg for the rats
0.12 - 0.26 g/kg for the mice - No. of animals per sex per dose:
- 96 animals total
- Control animals:
- no
- Details on study design:
- no additional data
- Statistics:
- no data
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 140 mg/kg bw
- Mortality:
- There was a total mortality of 43 animals, 6 between 0-1hr, 26 1and 6 hr and 11 between 6-24 hr.
- Clinical signs:
- intense excitation, nose, ears and feet became strongly red.
- Gross pathology:
- Lungs: hyperemia, haemorrhages, perivascular edema, slight peribronchrial pneumonic changes.
Heart, liver, kidneys: hyperemia
Other organs: no changes - Other findings:
- Survivors appeared recovered after 24 to 48 hr.
Any other information on results incl. tables
"A few minutes after injection a stage of intense excitation activity set in, lasting 10 -15 minutes, during which the animals ran about squeaking in the cage. At the same time peripheral parts of the body (nose, ears and feet) became strongly reddened. With the larger doses there were also general tremors or convulsions. The peripheral reddening subsided and disappeared in about an hour. With the larger doses death occured during or close to the stage of excitation. With the smaller doses the animals died most oftern during the night after the injections and no death occured later than 24 hours afterwards. The survivors seemed to have recovered after one to two days."
Applicant's summary and conclusion
- Conclusions:
- Crotonaldehyde resulted toxic via subcutaneous and more toxic in rats than in mice.
- Executive summary:
A subcutaneous toxicity study with crotonaldehyde indicated that the substance is toxic to rats and mice and suggested that the lungs and respiratory tract were the target organs. The LD50 was 0.16 g/kg in the mouse and 0.14 g/kg in the rat.
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