Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-095-9 | CAS number: 103-28-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data from peer reviewed journals and modelling databases
- Justification for type of information:
- data from peer reviewed journals and modelling databases
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To determine the octanol-water partition coefficient of test chemical.
- GLP compliance:
- not specified
- Type of method:
- other: calculated value
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 2.99
- Remarks on result:
- other: no additional details mentioned
- Conclusions:
- The estimated/calculated partition coefficient of test chemical was 2.99 dimensionless.
- Executive summary:
Data from peer reviewed articles and various modeling databases indicates that the estimated/ calculated partition coefficient of test chemical was 2.99 dimensionless.
Reference
Description of key information
The partition Coefficient n-octanol/water of test chmeical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared.
The reference substances4-Acetylpyridine, Biphenyl, Benzyl Benzoate, Cinnamic Acid, Toluene, Ethylbenzene, Naphthalene, n-Butylbenzene were chosen having log Pow range from 0.5 to 4.6.
The Log Pow value was determined to be2.995± 0.001dimensionless at 25°C.This value indicates that the substance is hydrophilic in nature.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.99
- at the temperature of:
- 25 °C
Additional information
The partition Coefficient n-octanol/water of test chmeical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared.
The reference substances4-Acetylpyridine, Biphenyl, Benzyl Benzoate, Cinnamic Acid, Toluene, Ethylbenzene, Naphthalene, n-Butylbenzene were chosen having log Pow range from 0.5 to 4.6.
The Log Pow value was determined to be 2.995± 0.001 dimensionless at 25°C.This value indicates that the substance is hydrophilic in nature.
To support the experiment study data from peer reviewed articles and various modeling databases have been reviewed which indicates that the estimated/ calculated partition coefficient of test chemical was 2.99.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
