3,7-dimethylnon-6-en-1-yn-3-ol

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: well documented guideline study

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2000

Report date:

2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethylnon-6-en-1-yn-3-ol

EC Number:

246-061-9

EC Name:

3,7-dimethylnon-6-en-1-yn-3-ol

Cas Number:

24173-47-5

Molecular formula:

C11H18O

IUPAC Name:

3,7-dimethylnon-6-en-1-yn-3-ol

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

2.9 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mobility

Any other information on results incl. tables

-

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The 48h-EC5O was 2.9 mg/I based on average measured exposure concentrations

Executive summary:

The project started with a range-finding test exposing Daphnia for 48 hours to a concentration

range of 0.1 to 100 mg/l forming a geometric progression with a factor of 10. All organisms

exposed to 100 mg/l became immobilised, while no immobilisation was observed at 10 mg/l and

lower. The EC5O was expected to be between 10 and 100 mg/l.

Based on the results of the range-finding test an EC50 test was performed with daphnids exposed to a concentration range of 10 to 100 mg/l, increasing with a factor of 1.8. The results were not in agreement with the results of the range-finding test. At nominal 10 mg/l, 19 out of 20 organisms exposed became immobilised during the test period, while no immobilisation was observed at 10 mg/l in the range-finding test. As a consequence of this contradiction it was decided to perform a second final EC50 study with a lower range of test concentrations. A final EC50 test was performed with Daphnia exposed to concentrations of 1.8, 3.2, 5.6, 10

and 18 mg/l. The test was performed in duplicate with 10 Daphnia per vessel. The results of the final EC50 test confirmed the results of the first EC50 test. Samples for determination of actual exposure concentrations were taken at the start and the end of the 48-hour test period.

ETHYLDEHYDROLINALOOL did not induce acute immobilisation of Daphnia magna at an average measured exposure concentration of 1.6 mg/l after 48 hours of exposure (NOEC). The 48h-EC50 was 2.9 mg/l based on average measured exposure concentrations.