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EC number: 619-646-5 | CAS number: 1067-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 Nov 2014 to 18 Dec 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Diethyl allylphosphonate
- EC Number:
- 619-646-5
- Cas Number:
- 1067-87-4
- Molecular formula:
- C7H15O3P
- IUPAC Name:
- Diethyl allylphosphonate
- Test material form:
- other: liquid
- Details on test material:
- Identification: Diethyl Allylphosphonate
Appearance/Physical State: Clear colorless liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: at 0 and 72 h; in the pre-test at 0, 0.1, 1.0, 10 and 100 mg/L, in the final test at 0 and 100 mg/L (pooled samples)
- Sample storage conditions before analysis: at -20 °C
Test solutions
- Vehicle:
- no
- Details on test solutions:
- test substance was directly added to medium (preparation under laboratory safety lighting due to potential light sensitivity of the substance)
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Pseudokirchnerella subcapitata
- Strain: CCAP 278/4
- Source: SAMS Research Services Ltd, Scottish Marine Institute, Oban, Argyl, Scotland
ACCLIMATION
- Acclimation period: 100 mL master culture with 10E3 cells/mL was kept at 24±1 °C under constant agitation (100-150 rpm) and constant illumination until the total number of cells was 10E4-10E5/mL
- Cultivation medium: similar to test medium
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 24±1 °C
- pH:
- 7.7-8.4
- Nominal and measured concentrations:
- pre-test: nominal 0, 0.1, 1.0, 10 and 100 mg/L; measured at 100 mg/L 93% and 87% of nominal at 0 and 72 h respectively
main test: nominal 0 and 100 mg/L; measured at 0 mg/L < LOQ at 0 and 72 h, at 100 mg/L 87 % and 96% of nominal at 0 and 72 h respectively - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 mL glass conical flasks
- Type: closed plugged with polyurethane foam
- Initial cells density: 5.8E03 cells/mL
- Control end cells density: 9.17E05 cells/mL
- No. of vessels per concentration (replicates): 6
- No. of vessels per control (replicates): 6
GROWTH MEDIUM
- Standard medium used: yes AAP according to guidance
TEST MEDIUM
- Source/preparation of dilution water: reversed osmosis purified deionized water
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Photoperiod: continuous
- Light intensity and quality: 7000 Lux
- Shaken: 150 rpm
EFFECT PARAMETERS MEASURED
- Determination of cell concentrations: final test at 0, 24, 48 and 72 h with Coulter Counter
TEST CONCENTRATIONS,
- Range finding study: 0, 0.1. 1.0, 10 and 100 mg/L
- Test concentrations: 0 and 100 mg/L - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Results with reference substance (positive control):
- potassium dichromate ErC50 1.2 mg/L, EyC50 0.63 mg/L
- Reported statistics and error estimates:
- No statistical differences between 100 mg/L and control group for groth rate and inhibition of biomass
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The ErC50 for the test substance in an algal groth inhibition test is > 100 mg/L
- Executive summary:
Algae were exposed to 0 and 100 mg/L test substance during 72 hours. No effects on growth rate and biomass were found. The analyses for accuracy of preparations showed that the average measured concentrations were > 80% of nominal. Therefore the results are based on nominal concentrations.The ErC50 is > 100 mg/L
.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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