Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 639-566-4
CAS number: 165184-98-5
Skin irritation: irritating to the skin (Xi; R38) according to the Directive 67/548/EEC but not classified under the Regulation (EC) No. 1272/2008 (CLP)Eye irritation: Not classified.Respiratory irritation: No data.
A study was
identified as the key study (Brenda, 1993). This study was performed
according to the EU Method B.4 (Acute Toxicity: Dermal
Irritation/Corrosion) and in compliance with GLP. New Zealand White
rabbits were dermally exposed to undiluted Hexyl cinnamic aldehyde (HCA)
for 4 hours using a semi-occlusive patch. The mean individual scores
calculated within 3 scoring times (24, 48 and 72 hours) were 2/2/2 for
erythema and 1.33/1.67/1.67 for oedema. All the reactions were fully
reversible within 11 days.
test conditions HCA is classified as irritating to skin (Xi; R38)
according to the Directive 67/548/EEC but is not classified under the
Regulation (EC) No. 1272/2008 (CLP).
supporting studies show similar results.
A study was
identified as the key study (Brenda, 1994). This study was performed
according to the EU Method B.5 (Acute Toxicity: Eye Irritation /
Corrosion) and in compliance with the GLP.
0.1 mL of
undiluted HCA was instilled into the conjunctival sac of male New
Zealand White rabbits. Under the test conditions, HCA didn’t induce eye
irritation. A transient redness of the conjunctivae was observed in both
the 3 tested animals (scores 0.3/0.33/0.33) but was fully reversible
within 2 days.
test conditions, HCA is not irritating to eyes.
harmonized classification is available according to the Regulation (EC)
No 1272/2008 including ATP1.
erythema scores equal 2 in the 3 tested animals, Hexyl cinnamic aldehyde
is self-classified as irritating to skin (Xi; R38) according to the
criteria of the Annex VI to the Directive 67/548/EC. However HCA is not
classified under the Regulation (EC) No 1272/2008.
is not classified for eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tato webová stránka používá cookies, aby se vám naše stránky používaly co nejlépe.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again