Registration Dossier
Registration Dossier
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EC number: 609-772-9 | CAS number: 40018-25-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in GLP compliance and according to an OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Chlorobenzoylacetonitril
- IUPAC Name:
- Chlorobenzoylacetonitril
- Test material form:
- other: solid
- Details on test material:
- Name: Chlorobenzoylacetoniril
Batch No. 46
Physical state: solid
Colour: yellow
Molecular weight: 179.61 g/mol
Purity: > 99%
Storage: in original container at 4°C
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH, Borchen
- Housing: in ABS Plastic cages, flor 4200cm²
- Diet (e.g. ad libitum): maintenance diet for rabbits ad libitum
- Water (e.g. ad libitum): tap water ad liitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +/- 3°C
- Humidity (%): 55%
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12:12 hrs
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0,5g per site/rabbit - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48, 72 hours after treatment
- Number of animals:
- 3 female rabbits
- Details on study design:
- TEST SITE
- Area of exposure: 6cm²
- % coverage: 100
- Type of wrap if used: gauze patch / non-irritating tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with water
- Time after start of exposure: 4 hrs
SCORING SYSTEM: as described in OECD 404 guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: all animals
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal: all animals
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 0
Any other information on results incl. tables
The test item showed no irritant effects on the skin after 4 hours of application. No skin reactions (erythema, oedema) were recorded throughout the obeservation period of 72 hours.There were no significant changes in body weights observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item was determined to be not irritating.
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