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Registration Dossier
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EC number: 202-855-7 | CAS number: 100-47-0
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Remarks:
- Original reference in foreign language (Russian)
Data source
Reference
- Reference Type:
- publication
- Title:
- Characteristics of the response of animals of different ages to the single and chronic effect of benzonitrile
- Author:
- Agaev, F. B.; Alekperov, I. I.; Pavlova, L. P.
- Year:
- 1 977
- Bibliographic source:
- Gig. Tr. Prof. Zabol. (3), 40-2
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- exposure to 0.07 (+/- 0.01) mg/l air for 4 h/d (5 d/week; 4.5 month) in a 750 l chamber; dynamic method.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Benzonitrile
- EC Number:
- 202-855-7
- EC Name:
- Benzonitrile
- Cas Number:
- 100-47-0
- Molecular formula:
- C7H5N
- IUPAC Name:
- benzonitrile
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
- Reference substance name:
- Benzaldehyde
- EC Number:
- 202-860-4
- EC Name:
- Benzaldehyde
- Cas Number:
- 100-52-7
- Molecular formula:
- C7H6O
- IUPAC Name:
- benzaldehyde
- Reference substance name:
- Terephthalonitrile
- EC Number:
- 210-783-2
- EC Name:
- Terephthalonitrile
- Cas Number:
- 623-26-7
- Molecular formula:
- C8H4N2
- IUPAC Name:
- terephthalonitrile
- Reference substance name:
- Benzene-1,3-dicarbonitrile
- EC Number:
- 210-933-7
- EC Name:
- Benzene-1,3-dicarbonitrile
- Cas Number:
- 626-17-5
- Molecular formula:
- C8H4N2
- IUPAC Name:
- isophthalonitrile
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 hours/day
- Frequency of treatment:
- 5 days/week; 4.5 month
Doses / concentrations
- Dose / conc.:
- 70 mg/m³ air (nominal)
- Remarks:
- Basis: nominal conc.
- No. of animals per sex per dose:
- 10 per age (young/adult/old)
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- conc. level: 70 mg/m³
- Effect level:
- 70 mg/m³ air (nominal)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: decrease of haemoglobin
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
First transient effects in adult rats occur after 5 days, normalizing until the end of the first month (except some CNS effects). After 90 days there was a significant decrease in the number of red blood cells in adults, together with an decrease in haemoglobin and increase in the number of leucocytes.
Applicant's summary and conclusion
- Conclusions:
- Subchronic exposure to Benzonitrile causes effects like a significant decrease in the number of red blood cells, decrease in haemoglobin and increase in the number of leucocytes. In contrast to acute exposure no age-dependency was found at a concentration of 0.07 mg/l in this study.
- Executive summary:
In an inhalation toxicity study groups of 10 male albino rats of different ages (young, adult and old: body weight ranging from 60 to 370 g) were exposed to benzonitrile for 4 h in a 750 l chamber 5 days/week for 4.5 months at a concentrations of 0.07 mg/l air.
A significant decrease in the number of red blood cells, a decrease in haemoglobin and an increase in the number of leucocytes were observed. In contrast to acute exposure no age-dependency was found in this study.
Due to the poor documentation it is not possible to assess the relevance and reliability of this study.
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