Registration Dossier
Registration Dossier
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EC number: 202-855-7 | CAS number: 100-47-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Benzoesäurenitril, Benzonitril, Phenylcyanid
- Author:
- Stout, A.
- Year:
- 1 932
- Bibliographic source:
- Fortschritte der Heilstoffchemie, 2. Abt., Bd. II
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no details reported; collection of data
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Benzonitrile
- EC Number:
- 202-855-7
- EC Name:
- Benzonitrile
- Cas Number:
- 100-47-0
- Molecular formula:
- C7H5N
- IUPAC Name:
- benzonitrile
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
- Reference substance name:
- Benzaldehyde
- EC Number:
- 202-860-4
- EC Name:
- Benzaldehyde
- Cas Number:
- 100-52-7
- Molecular formula:
- C7H6O
- IUPAC Name:
- benzaldehyde
- Reference substance name:
- Terephthalonitrile
- EC Number:
- 210-783-2
- EC Name:
- Terephthalonitrile
- Cas Number:
- 623-26-7
- Molecular formula:
- C8H4N2
- IUPAC Name:
- terephthalonitrile
- Reference substance name:
- Benzene-1,3-dicarbonitrile
- EC Number:
- 210-933-7
- EC Name:
- Benzene-1,3-dicarbonitrile
- Cas Number:
- 626-17-5
- Molecular formula:
- C8H4N2
- IUPAC Name:
- isophthalonitrile
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
Test animals
- Species:
- other: mouse, pigeons and rabbits
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Doses:
- no data reported
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- EC50
- Effect level:
- 180 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: mouse
- Sex:
- not specified
- Dose descriptor:
- EC50
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: pigeons
- Sex:
- not specified
- Dose descriptor:
- EC50
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: rabbit
Applicant's summary and conclusion
- Conclusions:
- The abstract cites studies which determined lethal doses (subcutaneous) for mouse = 180 mg/kg, pigeons = 500 mg/kg and rabbits = 200 mg/kg.
- Executive summary:
The abstract cites studies which determined lethal doses (subcutaneous) for mouse = 180 mg/kg, pigeons = 500 mg/kg and rabbits = 200 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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