Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: -
  • IUPAC name: 3,6-bis(4-chlorophenyl)-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione
  • Other names
EC / List no.:
401-540-3
CAS no.:
-
Index number:
Molecular formula:
C18H10Cl2N2O2
SMILES:
ClC1=CC=C(C=C1)C1=C2C(=O)NC(=C2C(=O)N1)C1=CC=C(Cl)C=C1
InChI:
InChI=1S/C18H10Cl2N2O2/c19-11-5-1-9(2-6-11)15-13-14(18(24)21-15)16(22-17(13)23)10-3-7-12(20)8-4-10/h1-8H,(H,21,24)(H,22,23)
Type of substance:
Mono constituent substance
Origin:
Organic, Other
Registered compositions:
15
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.
According to the majority of notifications provided by companies to ECHA in CLP notifications no hazards have been classified.

Breakdown of all 292 C&L notifications submitted to ECHA

Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 27 active registrations under REACH, 1 Joint Submission(s) and 5 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:
Nanomaterials in the EU Market

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000+ tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: coating products, inks and toners and polymers.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following activities or processes at workplace: high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), production of mixtures or articles by tabletting, compression, extrusion or pelletisation and the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: in the production of articles, formulation of mixtures and formulation in materials. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

This substance can be found in complex articles, with no release intended: vehicles. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), metal (e.g. cutlery, pots, toys, jewellery), rubber (e.g. tyres, shoes, toys), wood (e.g. floors, furniture, toys) and paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).

This substance is used in the following products: inks and toners and coating products.

This substance is used in the following areas: printing and recorded media reproduction and building & construction work. This substance is used for the manufacture of: machinery and vehicles, plastic products and textile, leather or fur.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, mixing in open batch processes, non-industrial spraying, hand mixing with intimate contact only with personal protective equipment available, treatment of articles by dipping and pouring, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).

This substance is used in the following products: coating products, inks and toners and polymers.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed batch processing in synthesis or formulation, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, laboratory work, batch processing in synthesis or formulation with opportunity for exposure and calendering operations.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, in the production of articles, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following products: coating products, inks and toners and polymers.

This substance is used in the following areas: printing and recorded media reproduction and formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products, rubber products, wood and wood products and pulp, paper and paper products.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, transfer of chemicals, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, calendering operations and roller or brushing applications.

Release to the environment of this substance can occur from industrial use: in the production of articles and formulation in materials. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • BASF Colors & Effects GmbH, An der Rheinschanze 1 67059 Ludwigshafen Germany
  • BASF Lampertheim GmbH, Chemiestrasse 22 68619 Lampertheim Germany
  • Chemservice S.A. (H5P7), 5, an de Laengten 6776 Grevenmacher Luxembourg
  • CINIC Chemicals Europe Sárl, 9 Croisée Des Lys 68300 Saint Louis France
  • Clariant Plastics & Coatings (Deutschland) GmbH, Brüningstrasse 50 65929 Frankfurt am Main Germany
  • Daicolorchem EU S.A. - OR - company 002, Pol. Ind. Baix Ebre 165 43897 Campredo Tortosa Spain
  • Gustav Grolman GmbH & Co. KG, Fuggerstr. 1 41468 Neuss Germany
  • Heubach Research Centre s. r. o., S. K. Neumanna 1316 53207 Pardubice Czech Republic
  • Iris Green s.r.l., V. Frediani,34 59100 PRATO ITALY Italy
  • Orgareach, rue de Wedel ZI 59541 CAUDRY France
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • Sun Chemical A/S 8, Københavnsvej 112 DK-4600 Køge Denmark
  • Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands
  • Synthesia, a.s., Semtín103 53002 Pardubice Czech Republic
  • Thomas Swan & Co. Ltd., Rotary Way DH8 7ND Consett Co. Durham United Kingdom
  • TOYO INK EUROPE SPECIALTY CHEMICALS, Boulevard Dambourney 76350 Oissel France
  • Trust Chem Europe B.V., Bergpoortstraat 65 NL-7411 CL Deventer Netherlands

Other names

  • 1,4-bis(4-chlorophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-3,6-dione
  • 3, 6 - bis (4 - chlorophenyl)- 2, 5 - dihydro - 1, 4 - diketo pyrrolo [3, 4 - c] pyrrole
  • 3,6-Bis (4-chlorophenyl)-2,5-dihydro-pyrrolo[3,4-c]pyrrol-1,4-dione
  • 3,6-Bis (4-chlorophenyl)-2,5-dihydro-pyrrolo[3,4-c]pyrrole-1,4-dione
  • 3,6-bis(4-chlorophenyl)-1H,2H,4H,5H-dihydro-pyrrolo[3,4-c]pyrrole-1,4-dione
  • 3,6-bis(4-chlorophenyl)-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione
  • 3,6-Bis(4-chlorophenyl)-2,5-dihydropyrrolo-(3,4-c)pyrrole-1, 4-dione
  • 3,6-bis(4-chlorophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrol-1,4-dione
  • 3,6-bis(4-chlorophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione
  • Fastogen Super Red 254
  • Pigment Red 254
  • -
  • CROMOPHTAL DPP RED BP
  • 3,6-bis(4-chlorophenyl)-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione
  • CASACOLOUR 2540
  • CINILEX DDP RED SR1C
  • Cinilex DPP Red SR2P
  • CROMOPHTAL DPP RED BP
  • D2G 70
  • FASTOGEN SUPER RED 254
  • FASTOGEN SUPER RED 254 226-020
  • FASTOGEN SUPER RED 254 226-0200
  • HEUCO RED 325401
  • Irgazin Red L 3670
  • Lionogen Red DT1400Lionogen Red DT1410Lionogen Red DT1441Lionogen Red DT1451Lionogen Red DT1460Lionogen Red DT1470
  • MONOLITE RED 325401
  • MONOLITE RED 325402
  • Pigment Red 254
  • Verdcol DPP Red 254 PTR
  • VYNAMON RED 325401

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 18 studies submitted
  • 8 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [8]
C Form
Powder (100%) [8]
C Odour
Odourless (67%), Faint (17%), Other (17%) [6]
C Substance type
Organic (88%), Other (13%) [8]

Type of Study provided
Studies with data
Key study 9
Supporting study 1
Weight of evidence
Other 8
Data waiving
no waivers
C Summaries
  • 7 summaries submitted
  • 7 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 10 studies submitted
  • 8 studies processed
R Melting / freezing point
300 - 450 °C [8]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 4 summaries processed
Melting / freezing point at 101 325 Pa
300 °C

Boiling point

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible 1
Sci. unjustified 4
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 10 studies submitted
  • 8 studies processed
R Density
1.58 - 1.635 g/cm³ @ 20 - 25.2 °C [4]
R Relative density
1.58 @ 20 °C [4]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 7 summaries processed
Relative density at 20°C
1.58

Vapour pressure

Study results
  • 11 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other 4
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 18 studies submitted
  • 12 studies processed
R Pow
3.37 @ 24 °C and pH 7 [1]
R Log Pow
0.53 - 3 @ 24 - 25 °C and pH 5 - 9 [23]

Type of Study provided
Studies with data
Key study 6 3
Supporting study 1
Weight of evidence 5
Other 3
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 5 summaries processed
Log Kow (Log Pow)
2.4 - 3 @ 20 °C

Water solubility

Study results
  • 14 studies submitted
  • 10 studies processed
R Water solubility (mass/vol.)
400 - 10 000 000 ng/L @ 20 - 24 °C and pH 5.9 - 7.7 [10]

Type of Study provided
Studies with data
Key study 7 2
Supporting study 1
Weight of evidence 1
Other 3
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 3 summaries processed
Water solubility
30 µg/L @ 23 °C

Solubility in organic solvents / fat solubility

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other 4
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible 1
Sci. unjustified 6
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 12 studies submitted
  • 5 studies processed
R Autoflammability / self-ignition
400 °C @ 101.3 kPa [5]

Type of Study provided
Studies with data
Key study 8
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 4 summaries processed
Autoflammability / self-ignition at 101 325 Pa
400 °C

Flammability

Study results
  • 16 studies submitted
  • 3 studies processed
C Interpretation of results
Non flammable (100%) [3]

Type of Study provided
Studies with data
Key study 8
Supporting study 2
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 7 summaries submitted
  • 5 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 12 studies submitted
  • 3 studies processed
C Interpretation of results
Non-explosive (100%) [3]

Type of Study provided
Studies with data
Key study 7
Supporting study 2
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 6 summaries submitted
  • 6 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 11 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 6
Supporting study 1
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 7 summaries submitted
  • 6 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible 5
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 16 studies submitted
  • 9 studies processed
C Interpretation of results
Under test conditions no biodegradation observed (56%), Not inherently biodegradable (44%) [9]

Type of Study provided
Studies with data
Key study 7
Supporting study
Weight of evidence 3
Other 2 3
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
C Summaries
  • 6 summaries submitted
  • 4 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 11 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 6 summaries submitted
  • 3 summaries processed
Koc at 20°C
341.5

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
0 Pa m³/mol @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 0 % [1]
R Water 84.9 % [1]
R Soil 6.71 % [1]
R Sediment 6.79 % [1]
R Suspended sediment 0.04 % [1]
R Biota 0 % [1]
R Aerosol 1.54 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 8 summaries submitted
  • 8 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 499 - 10 000 µg/L (3)
Intermittent releases (freshwater) 499 - 1 000 µg/L (3)
Marine water 499 - 1 000 µg/L (3)
Intermittent releases (marine water) No data: aquatic toxicity unlikely (1)
Sewage treatment plant (STP) 1 mg/L (3)
Sediment (freshwater) 377 - 668 mg/kg sediment dw (3)
Sediment (marine water) 37.7 - 668 mg/kg sediment dw (3)
Hazard for Air
Air No hazard identified (5)
Hazard for Terrestrial Organism
Soil 1 mg/kg soil dw (3)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (6)

Short–term toxicity to fish

Study results
  • 8 studies submitted
  • 6 studies processed
P/RResults
LC50 (4 days) 100 mg/L [6]
LC0 (4 days) 100 mg/L [2]
LC100 (4 days) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 7
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 3 summaries processed
LC50 for freshwater fish
100 mg/L

Long–term toxicity to fish

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 5 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater fish
100 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 9 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 100 mg/L [1]
EC50 (24 h) 100 mg/L [2]
EC0 (24 h) 100 mg/L [2]
EC100 (24 h) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 3 summaries processed
EC50 / LC50 for freshwater invertebrates
100 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 8 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater invertebrates
100 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 12 studies submitted
  • 4 studies processed
P/RResults
EC50 (72 h) 100 mg/L [5]
NOEC (72 h) 100 mg/L [2]
LOEC (72 h) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 7
Supporting study 1
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 5 summaries submitted
  • 3 summaries processed
EC50 for freshwater algae
100 mg/L
EC10 or NOEC for freshwater algae
100 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 8 studies submitted
  • 6 studies processed
P/RResults
EC50 (3 h) 100 - 1 000 mg/L [6]
NOEC (3 h) 1 g/L [1]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 5 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 9 studies submitted
  • 2 studies processed
P/RResults
LC50 (14 days) 1 g/kg soil dw [1]
LC0 (14 days) 1 g/kg soil dw [2]
LC0 (14 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Short-term EC50 / LC50
1 g/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 10 studies submitted
  • 3 studies processed
P/RResults
NOEC (15 days) 1 g/kg soil dw [2]
EC0 (15 days) 1 g/kg soil dw [2]
EC100 (15 days) 1 g/kg soil dw [2]
LC0 (15 days) 1 g/kg soil dw [2]
LC100 (15 days) 1 g/kg soil dw [2]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
R Summaries
  • 5 summaries submitted
  • 2 summaries processed
Short-term EC50 / LC50
1 g/kg soil dw

Toxicity to soil microorganisms

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 1
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 8 summaries submitted
  • 7 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 9.8 mg/m³ repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.33 mg/kg bw/day repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary)
Local Effects
Long-term: Hazard unknown (no further information necessary)
Acute /short term: Hazard unknown (no further information necessary)
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.898 mg/m³ repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.66 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Hazard unknown (no further information necessary)
Acute /short term: Hazard unknown (no further information necessary)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.66 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 8
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 6 summaries submitted
  • 5 summaries processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 50 %
Dermal: 50 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 9 studies submitted
  • 3 studies processed
P/RResults
LD50 5 000 mg/kg bw (rat) [2]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 5 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
inhalation
  • 10 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 h) 2.25 mg/L air (rat) [3]
LC0 (4 h) 2.25 mg/L air (rat) [1]
M/CInterpretations of results
Not classified [1]

inhalation
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
dermal
  • 8 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [2]

dermal
Studies with data
Key study 8
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 7 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed Discriminating dose 5 000 mg/kg bw
Inhalation route:
No adverse effect observed Discriminating conc. 2 250 mg/m³
Dermal route:
No adverse effect observed Discriminating dose 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: eye
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
M/C Summaries
  • 7 summaries submitted
  • 7 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 11
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 7 summaries submitted
  • 7 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 12 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 1 000 mg/kg bw/day [3]

Type of Study provided
Study data: oral
Studies with data
Key study 8
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Study data: inhalation
  • 6 studies submitted
  • 1 study processed
P/RResults
NOAEC (rat): 30 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
M/C Summaries
  • 7 summaries submitted
  • 3 summaries processed
Oral route - systemic effects:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 30 mg/m³ (subacute, rat)
Inhalation route - local effects:
No adverse effect observed NOAEC 30 mg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 26 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 13 1
Supporting study 1 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 6
Exposure cons.
Other 3
Study data: in vivo
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 7 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other 3
Study data: developmental
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 2
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant