Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Alkenes, C8-10-branched, C9-rich
  • IUPAC name:
  • Other names
EC / List no.:
307-301-9
CAS no.:
97593-01-6
Index number:
Molecular formula:
(CH2)4-6C4H8
SMILES:
CCC(C)=C
InChI:
InChI=1S/C5H10/c1-4-5(2)3/h2,4H2,1,3H3
Type of substance:
UVCB
Origin:
Organic, Petroleum product
Registered compositions:
10
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may be fatal if swallowed and enters airways, is very toxic to aquatic life and is a highly flammable liquid and vapour.

Breakdown of all 11 C&L notifications submitted to ECHA

Not Classified
Asp. Tox. 1 H304
Aquatic Acute 1 H400
Flam. Liq. 2 H225
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 10 active registrations under REACH, 1 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 - 10 000 tonnes per year.

This substance is used in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following products: pH regulators and water treatment products and laboratory chemicals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

This substance is used in the following products: pH regulators and water treatment products and laboratory chemicals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, laboratory work, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), manufacturing of the substance, as processing aid, in processing aids at industrial sites, formulation of mixtures, formulation in materials, in the production of articles, as processing aid, for thermoplastic manufacture and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, laboratory work, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation of mixtures, formulation in materials, in the production of articles, as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: take actions to prevent static discharges; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; avoid release to the environment.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Collect spillage. Do not induce vomiting.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • EQUILEX, Jan Van Galenstraat 54 3115 JG SCHIEDAM Netherlands
  • ExxonMobil Chemical France SARL, Tour Manhattan, 5/6, Place de l'Iris 92400 Courbevoie France
  • ExxonMobil Chemical Holland B.V., Botlekweg, 121, Haven nr 40-60 NL 3197 KA Botlek Rotterdam Netherlands
  • ExxonMobil Chemical Ltd., Ermyn Way ExxonMobil House KT22 8UX Surrey Leatherhead United Kingdom
  • Hexion VAD B.V., Seattleweg 17 building 4 3195ND Pernis Rotterdam Netherlands
  • Janex International B.V., Westblaak 89 3012 KG Rotterdam Netherlands
  • knoell Germany - OR - B15, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • Oy Nizhex Scandinavia Ltd, Wavulinintie 10 00210 HELSINKI Finland
  • Sasol Germany GmbH, Anckelmannsplatz 1 D-20537 Hamburg Germany
  • SI Group-UK, Ltd., Four Ashes WV 10 7BT Wolverhampton United Kingdom
  • Total Raffinage France, 2, place Jean Millier, La Défense 92400 Courbevoie France

Other names

  • -
  • Alkenes, C8-10-branched,
  • Alkenes, C8-10-branched, C9 rich
  • Alkenes, C8-10-branched, C9-rich
  • Nonene
  • Alkenes, C8-10-branched, C9-rich
  • Nonene
  • NONENES, PROPYLENE TRIMER, NONENE, NONENE NA, NONENE S
  • Propylene trimer
  • trimer propylene
  • Tripropylene

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 90 studies submitted
  • 77 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (92%), Solid (8%) [77]
C Form
Not specified (81%), Other (13%), Viscous (6%) [62]
C Odour
Other (100%) [46]
C Substance type
Organic (86%), Other (10%) [58]

Type of Study provided
Studies with data
Key study 78
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Melting/freezing point

Study results
  • 50 studies submitted
  • 34 studies processed
R Melting / freezing point
-133 - 68.333 °C @ 101.3 - 101.325 kPa [34]

Type of Study provided
Studies with data
Key study 34
Supporting study 14
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 82 studies submitted
  • 48 studies processed
R Boiling point
60 - 367 °C @ 100.8 - 101.67 kPa [50]

Type of Study provided
Studies with data
Key study 50
Supporting study 4 16
Weight of evidence
Other 12
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 70 studies submitted
  • 44 studies processed
R Density
0.67 - 0.82 g/cm³ @ 20 - 35 °C [44]
R Relative density
0.67 - 0.76 @ 20 °C [4]

Type of Study provided
Studies with data
Key study 54
Supporting study 14
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 58 studies submitted
  • 34 studies processed
R Vapour pressure
0.017 - 62 000 Pa @ 20 - 171.111 °C [54]

Type of Study provided
Studies with data
Key study 34
Supporting study 12
Weight of evidence
Other 12
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 150 studies submitted
  • 66 studies processed
R Log Pow
1.5 - 13.96 @ 20 - 25 °C and pH 5.4 - 7 [70]

Type of Study provided
Studies with data
Key study 36 30
Supporting study 56 10
Weight of evidence
Other 18
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 102 studies submitted
  • 46 studies processed
R Water solubility (mass/vol.)
0 - 88 500 000 ng/L @ 20 - 25 °C and pH 5.5 - 7.46 [50]

Type of Study provided
Studies with data
Key study 26 20
Supporting study 42 4
Weight of evidence
Other 10
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 70 studies submitted
  • 50 studies processed
R Flash point
-25 - 218 °C @ 99.9 - 101.9 kPa [50]

Type of Study provided
Studies with data
Key study 50
Supporting study 14
Weight of evidence
Other 6
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 34 studies submitted
  • 18 studies processed
R Autoflammability / self-ignition
222 - 285 °C @ 101.3 - 103.2 kPa [18]

Type of Study provided
Studies with data
Key study 18
Supporting study 10
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 14 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 6
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 50 studies submitted
  • 32 studies processed
R Other:
0.42 - 6.356 [14]
R dynamic viscosity (in mPa s)
0.202 - 5.04 [12]
R kinematic viscosity (in mm²/s)
0.66 - 19.3 [24]

Type of Study provided
Studies with data
Key study 32
Supporting study 16
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 4 studies submitted
  • 4 studies processed
R Dissipation half life (DT50)
10.2 h [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 176 studies submitted
  • 62 studies processed
R BOD5
1.64 g O2/g test material [4]
R COD
2.81 g O2/g test material [4]
C Interpretation of results
Readily biodegradable (59%), Not readily biodegradable (31%), Readily biodegradable but failing the 10-day window (10%) [58]

Type of Study provided
Studies with data
Key study 42 38
Supporting study 48 48
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 140 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 36 36
Supporting study 34 34
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 56 studies submitted
  • 48 studies processed
R log Koc
2.59 - 6.63 dimensionless @ 20 °C [48]

Type of Study provided
Studies with data
Key study 2 28 26
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 48 studies submitted
  • 46 studies processed
R H - (pressure) m³/mol
10 800 - 1 122 150 Pa m³/mol @ 20 - 25 °C and 101.3 kPa [46]

Type of Study provided
Studies with data
Key study 24 24
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 5.3 µg/L (1)
Intermittent releases (freshwater) 5.3 µg/L (1)
Marine water 5.3 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) No hazard identified (1)
Sediment (freshwater) 3.3 mg/kg sediment dw (1)
Sediment (marine water) 3.3 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 680 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential to cause toxic effects if accumulated (in higher organisms) via the food chain (1)

Short–term toxicity to fish

Study results
  • 92 studies submitted
  • 24 studies processed
P/RResults
LC50 (4 days) 3.4 - 6 600 µg/L [24]
NOEC (4 days) 3.4 - 2 890 µg/L [12]

Type of Study provided
Studies with data
Key study 24 24
Supporting study 6 22 16
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 96 studies submitted
  • 12 studies processed
P/RResults
EC50 (48 h) 2.8 - 4 400 µg/L [12]
NOEC (48 h) 2.8 - 560 µg/L [8]

Type of Study provided
Studies with data
Key study 18 18
Supporting study 10 30 20
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
NOEC (21 days) 19.4 µg/L [4]
LOEC (21 days) 28.7 µg/L [4]
EC50 (21 days) 28.1 µg/L [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 104 studies submitted
  • 12 studies processed
P/RResults
EC50 (4 days) 4.5 - 5.5 mg/L [12]
EC50 (72 h) 930 - 1 800 000 ng/L [8]
NOEC (4 days) 230 - 1 800 µg/L [12]
NOEC (72 h) 930 ng/L [4]

Type of Study provided
Studies with data
Key study 20 20
Supporting study 12 32 20
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 92 studies submitted
  • 40 studies processed
P/RResults
EC50 (3 h) 1 g/L [4]
NOEC (28 days) 2 mg/L [16]
NOEC (14 days) 2 - 17.1 mg/L [12]
NOEC (5 days) 2 - 3 mg/L [8]
NOEC (3 h) 1 g/L [4]

Type of Study provided
Studies with data
Key study 28 28
Supporting study 18 18
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 46 studies submitted
  • 12 studies processed
P/RResults
LC50 (10 days) 182 - 4 780 mg/kg sediment dw [12]
LC50 (10 days) 182 - 4 780 mg/kg sediment dw [12]

Type of Study provided
Studies with data
Key study 8 8
Supporting study 14 14
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 32 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 4 4
Supporting study 12 12
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 92 studies submitted
  • 56 studies processed
P/RResults
LD50 2 000 - 10 000 mg/kg bw (rat) [36]
LD50 5 mL/kg bw (rat) [4]
approx. LD50 10 mL/kg bw (rat) [8]
M/CInterpretations of results
Study cannot be used for classification [4]

Type of Study provided
oral
Studies with data
Key study 30 26
Supporting study 18 18
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 80 studies submitted
  • 52 studies processed
P/RResults
LC50 (6 h) 46.3 mg/L air (rat) [4]
LC50 (4 h) 2.1 mg/L air (rat) [4]
LC50 (4 h) 8 050 ppm (rat) [4]
LC50 (6 h) 46.3 mg/L air (mouse) [4]
LC50 (6 h) 46.3 mg/L air (guinea pig) [4]
M/CInterpretations of results
Other [52]

inhalation
Studies with data
Key study 8 8
Supporting study 14 14
Weight of evidence 18 18
Other
Data waiving
no waivers
dermal
  • 88 studies submitted
  • 48 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [12]
LD50 4 mL/kg bw (rat) [4]
approx. LD50 2 - 4 mL/kg bw (rat) [4]
LD50 2 000 - 10 000 mg/kg bw (rabbit) [12]
LD50 2 mL/kg bw (rabbit) [4]
M/CInterpretations of results
Category 5 based on GHS criteria [8]

dermal
Studies with data
Key study 24 24
Supporting study 20 20
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 28 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study 14 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 148 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 32 32
Supporting study 40 44
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 98 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 33 29
Supporting study 18 18
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 62 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 28 28
Supporting study 2 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 110 studies submitted
  • 24 studies processed
P/RResults
NOAEL (rat): 500 - 1 000 mg/kg bw/day [12]
NOEL (rat): 20 - 1 000 mg/kg bw/day [20]
LOEL (rat): 20 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 12 12
Supporting study 41 43
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: inhalation
  • 16 studies submitted
  • 4 studies processed
P/RResults
NOAEC (rat): 3 000 ppm [4]

Study data: inhalation
Studies with data
Key study 4
Supporting study 4 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Study data: dermal
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 4 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 120 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 52 52
Supporting study 8 8
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 24 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 12 8
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 46 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2 2
Supporting study 16 16
Weight of evidence
Other 10
Data waiving
no waivers
Study data: developmental
  • 66 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2 2
Supporting study 26 26
Weight of evidence
Other 10
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 300 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Study results
  • 28 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 12 12
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant