Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

No image available
EC / List no.:
295-463-0
CAS no.:
92045-80-2
Index number:
649-117-00-4
Molecular formula:
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Petroleum product
Registered compositions:
6
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01corr) approved by the European Union, this substance may cause genetic defects, may cause cancer and is an extremely flammable gas.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may be fatal if swallowed and enters airways, is toxic to aquatic life with long lasting effects, may damage fertility or the unborn child, causes damage to organs through prolonged or repeated exposure, is harmful if inhaled, contains gas under pressure and may explode if heated and may cause drowsiness or dizziness.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may cause damage to organs through prolonged or repeated exposure.

Breakdown of all 73 C&L notifications submitted to ECHA

Flam. Gas 1 H220 Harmonised Classification
Press. Gas (Liq.) H280
Repr. 1A H360
STOT SE 3 H336
Asp. Tox. 1 H304
Muta. 1B H340 Harmonised Classification
Carc. 1A H350 Harmonised Classification
Acute Tox. 4 H332
Aquatic Chronic 2 H411
Aquatic Chronic 3 H412
STOT RE 1 H372
STOT RE 2 H373
Carc. 1B H350
Muta. 1A H340
Press. Gas Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Carcinogenic (44.44% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L).
  • M
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Mutagenic (44.44% of REACH registrations).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (55.56% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 3 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels, air care products and coating products.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used for the manufacture of: chemicals and .

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates), manufacturing of the substance and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: obtain special instructions before use; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; avoid release to the environment; do not handle until all safety precautions have been read and understood; do not breathe the dust, fume, gas, mist, vapours or spray; keep away from clothing or other combustible materials; do not allow contact with air; avoid breathing the dust, fume, gas, mist, vapours or spray; do not eat, drink or smoke when using this product; use only outdoors or in a well-ventilated area; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: In case of leaking gas fire do not extinguish unless leak can be stopped safely. In case of leakage eliminate all ignition sources. If swallowed: immediately call a poison center or doctor/physician. Call a poison center or doctor/physician if you feel unwell. Get medical advice/attention if you feel unwell. Do not induce vomiting. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. If exposed or concerned: get medical advice/attention. Collect spillage. Follow specific treatment (see label).

Storage statements

Store this substance locked up; in a well-ventilated place and keeping container tightly closed; in a well-ventilated place; protected from sunlight and in a well-ventilated place; protected from sunlight.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • BNH-Oil Polska Sp.z.o.o., BUKOWIŃSKA 22 B 02-703 WARSZAWA Poland
  • INA, d.d., Avenija V.Holjevca 10 p.p. 555 10002 Zagreb Croatia
  • MOL Hungarian Oil and Gas Public Limited Company, Oktober huszonharmadika 18 1117 Budapest Hungary

Substance names and other identifiers

[A complex combination of hydrocarbons obtained by subjecting a liquified petroleum gas mix to a sweetening process to oxidize mercaptans or to remove acidic impurities. It consists predominantly of C4 saturated and unsaturated hydrocarbons.]
A complex combination of hydrocarbons obtained by subjecting a liquified petroleum gas mix to a sweetening process to oxidize mercaptans or to remove acidic impurities. It consists predominantly of C4 saturated and unsaturated hydrocarbons.
C&L Inventory
Petroleum gas
A complex combination of hydrocarbons obtained by subjecting a liquified petroleum gas mix to a sweetening process to oxidize mercaptans or to remove acidic impurities. It consists predominantly of C4 saturated and unsaturated hydrocarbons.
C&L Inventory
Petroleum gases, liquefied, sweetened, C4 fraction
EC Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Petroleum gases, liquefied, sweetened, C4 fraction
A complex combination of hydrocarbons obtained by subjecting a liquified petroleum gas mix to a sweetening process to oxidize mercaptans or to remove acidic impurities. It consists predominantly of C4 saturated and unsaturated hydrocarbons.
C&L Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Petroleum gases, liquefied, sweetened, C4 fraction; Petroleum gas [A complex combination of hydrocarbons obtained by subjecting a liquified petroleum gas mix to a sweetening process to oxidize mercaptans or to remove acidic impurities. It consists predominantly of C4 saturated and unsaturated hydrocarbons.]
A complex combination of hydrocarbons obtained by subjecting a liquified petroleum gas mix to a sweetening process to oxidize mercaptans or to remove acidic impurities. It consists predominantly of C4 saturated and unsaturated hydrocarbons.
Other, FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
(Keerulise koostisega süsivesinike segu, mis saadakse veeldatud naftagaasisegu demerkaptaanimisprotsessil merkaptaanide oksüdeerimiseks või happeliste lisandite eraldamiseks. Koosneb peamiselt C4 küllastatud ja küllastumata süsivesinikest.) (et)
C&L Inventory
[(Složitá směs uhlovodíků získaná slazením směsi zkapalněného ropného plynu za účelem oxidace merkaptanů nebo odstranění kyselých nečistot. Je složena převážně z nasycených a nenasycených uhlovodíků C4.] (cs)
C&L Inventory
[Kompleks blanding av hydrokarboner dannet ved å utsette en flytende petroleumsgassblanding for en søtningsprosess (sweetening-prosess) for å oksidere merkaptaner eller fjerne sure forurensninger. Består hovedsakelig av mettede og umettede C4-hydrokarboner.] (no)
C&L Inventory
[Kompleksna kombinacija ogljikovodikov dobljena z izpostavitvijo utekočinjene plinske zmesi zemeljskega olja procesu sladkanja za oksidacijo markaptanov ali za odstranitev kislih nečistoč. Sestoji pretežno iz C4 nasičenih in nenasičenih ogljikovodikov.] (sl)
C&L Inventory
[komplexe Kombination von Kohlenwasserstoffen, erhalten durch Süßung eines flüssigen Erdölgasgemischs zur Oxidation von Mercaptanen oder zum Entfernen saurer Verunreinigungen; besteht vorwiegend aus gesättigten und ungesättigten C4-Kohlenwasserstoffen] (de)
C&L Inventory
[Komplexná zmes uhľovodíkov získavaná odstraňovaním tiolov zo skvapalnenej zmesi ropného plynu, pričom tioly sa oxidujú (sladia), alebo odstraňovaním kyslých prímesí. Pozostáva predovšetkým z nasýtených a nenasýtených C4-uhľovodíkov.] (sk)
C&L Inventory
[O combinaţie complexă de hidrocarburi obţinută printr-un proces de desulfurare a amestecului gazelor petroliere lichefiate cu scopul oxidării mercaptanilor sau a îndepărtării impurităţilor acidice. Constă cu precădere în hidrocarburi saturate şi nesaturate C4.] (ro)
C&L Inventory
[Ogļūdeņražu savienojumu komplekss, kas iegūts, sašķidrinātu naftas gāzu maisījumu pakļaujot desulfurizācijas procesam, lai oksidētu merkaptānus vai atdalītu skabos piemaisījumus. Sastāv no piesātinātiem un nepiesātinātiem ogļūdeņražiem, galvenokārt ar oglekļa atomu skaitu C4.] (lv)
C&L Inventory
[Složeni sastav ugljikovodika dobivenih podvrgavanjem smjese ukapljenog naftnog plina procesu slađenja da se oksidiraju merkaptani ili uklone kisele nečistoće. Sastoji se pretežito od C4 zasićenih i nezasićenih ugljikovodika.] (hr)
C&L Inventory
[Sudėtinis angliavandenilių mišinys, gaunamas vykdant sieros šalinimo iš suskystintųjų naftos dujų mišinio procesą tioliams oksiduoti arba rūgštinėms priemaišoms pašalinti. Jį sudaro daugiausia C4 sotieji ir nesotieji angliavandeniliai.] (lt)
C&L Inventory
[Szénhidrogének komplex elegye, melyet úgy állítanak elő, hogy a cseppfolyósított kőolaj gázelegyet kéntelenítő eljárásnak vetik alá a merkaptánok oxidálása vagy a savas szennyeződések eltávolítása céljából. Főleg C4-es, telített és telítetlen szénhidrogénekből áll.] (hu)
C&L Inventory
[Złożona mieszanina węglowodorów otrzymana przez poddanie upłynnionej mieszaniny gazów ropy naftowej procesowi odsiarczania w celu utlenienia merkaptanów lub w celu usunięcia kwasowych zanieczyszczeń. Składa się głównie z węglowodorów C4 nasyconych i nienasyconych węglowodorów.] (pl)
C&L Inventory
[Πολύπλοκος συνδυασμός υδρογονανθράκων που λαμβάνεται όταν μείγμα υγραερίου πετρελαίου υποβάλλεται σε γλύκανση για την οξείδωση των μερκαπτανών ή την απομάκρυνση των οξίνων προσμίξεων. Συνίσταται κυρίως από κορεσμένους και ακόρεστους υδρογονάνθρακες C4.] (el)
C&L Inventory
[Комплексна комбинация от въглеводороди, получена при процеса на сероочистване, на който е подложена сместа от втечнени нефтени газове за окисляване на меркаптани или за отстраняване на кисели примеси. Състои се основно от С4 наситени и ненаситени въглеводороди. ] (bg)
C&L Inventory
Aardoliegassen, vloeibaar gemaakt, stankvrij gemaakt, C4-fractie (nl)
C&L Inventory
combinación compleja de hidrocarburos obtenida sometiendo una mezcla de gas de petróleo licuado a un proceso de desazufrado para oxidar los mercaptanos o separar impurezas ácidas; compuesta principalmente de hidrocarburos insaturados y saturados de C4 (es)
C&L Inventory
Combinaison complexe d'hydrocarbures obtenue en soumettant un mélange de gaz de pétrole liquéfiés à un procédé d'adoucissement destiné à oxyder les mercaptans ou à éliminer les impuretés acides. Se compose principalement d'hydrocarbures saturés et insaturés en C4. (fr)
C&L Inventory
Combinazione complessa di idrocarburi ottenuta sottoponendo una miscela di gas di petrolio liquefatti ad un processo di addolcimento per ossidare i mercaptani o per eliminare le impurezze acide. E costituita prevalentemente da idrocarburi C4 saturi ed insaturi. (it)
C&L Inventory
Combinação complexa de hidrocarbonetos obtida submetendo uma mistura de gases de petróleo liquefeitos a um processo de adoçamento (sweetening) para oxidação dos mercaptanos ou remoção das impurezas ácidas. É constituída predominantemente por hidrocarbonetos C4 saturados e insaturados. (pt)
C&L Inventory
Een complexe verzameling koolwaterstoffen die wordt verkregen door het stankvrij maken van een vloeibaar gemaakt aardolie-gasmengsel, om mercaptanen te oxideren of om zure verontreinigingen te verwijderen. Bestaat voornamelijk uit C4-verzadigde en onverzadigde koolwaterstoffen. (nl)
C&L Inventory
En sammensat blanding af carbonhydrider opnået ved at underkaste en fortættet råoliegasblanding en sweetening-proces for at omdanne mercaptaner eller fjerne sure urenheder. Den består overvejende af mættede og umættede C4-carbonhydrider. (da)
C&L Inventory
Erdölgase, flüssig, gesüßt, C4-Fraktion (de)
C&L Inventory
gas di petrolio (it)
C&L Inventory
gas di petrolio, liquefatti, addolciti, frazione C4 (it)
C&L Inventory
Gase aus der Erdölverarbeitung (de)
C&L Inventory
gases de petróleo (es)
C&L Inventory
gases de petróleo, licuados, desazufrados, fracción de C4 (es)
C&L Inventory
Gases de petróleo, liquefeitos, adoçados (sweetened), fracção C4 (pt)
C&L Inventory
gaz de pétrole (fr)
C&L Inventory
Gaz de pétrole liquéfiés, adoucis, fraction en C4; gaz de pétrole;[combination complexe d'hydrocarbures obtenue en soumettant un mélange de gaz de pétrole liquéfiés à un procédé d'adoucissement destiné à oxyder les thioalcools ou à éliminer les impuretés acides. Se compose principalement d'hydrocarbures saturés ou insaturés en C4.] (fr)
C&L Inventory
Gaz petrolier (mt)
C&L Inventory
Gaz petrolier (ro)
C&L Inventory
Gaz z ropy naftowej (pl)
C&L Inventory
Gaze petroliere, lichefiate, îndulcite, fracţia C4 (mt)
C&L Inventory
Gaze petroliere, lichefiate, îndulcite, fracţia C4 (ro)
C&L Inventory
Gazy naftowe, frakcja węglowodorów C4 skroplona, odsiarczona (pl)
C&L Inventory
Gás de petróleo (pt)
C&L Inventory
Komplex blandning av kolväten erhållen genom avsvavling av en flytande petroleumgasblandning för att oxidera merkaptaner eller avlägsna sura föroreningar. Består främst av mättade och omättade C4-kolväten. (sv)
C&L Inventory
Kulbrintegasser (da)
C&L Inventory
Kőolaj gáz (hu)
C&L Inventory
Kőolaj gázok, cseppfolósított, kéntelenített, C4 frakció (hu)
C&L Inventory
Maaöljykaasu (fi)
C&L Inventory
Maaöljykaasut, nesteytetty, makeutettu, C4-fraktio (fi)
C&L Inventory
Monimutkainen seos hiilivetyjä, saatu nesteytetystä maaöljykaasuseoksesta hapettamalla merkaptaanit tai poistamalla happamet epäpuhtaudet makeutusprosessilla. Koostuu pääasiassa C4-tyydyttyneistä ja -tyydyttymättömistä hiilivedyistä. (fi)
C&L Inventory
Naftagaas (et)
C&L Inventory
Naftagaasid, veeldatud, demerkaptaanitud, C4-fraktsioon (et)
C&L Inventory
Naftas gāze (lv)
C&L Inventory
Naftas gāzes, sašķidrinātas, attīrītas no sēra savienojumiem, C4 frakcija (lv)
C&L Inventory
Naftni plin (hr)
C&L Inventory
Naftni plinovi, ukapljeni, slađeni, C4 frakcija (hr)
C&L Inventory
Naftos dujos (lt)
C&L Inventory
Naftos dujos, suskystintosios, besierės, C4 frakcija (lt)
C&L Inventory
O combinaţie complexă de hidrocarburi obţinută printr-un proces de desulfurare a amestecului gazelor petroliere lichefiate cu scopul oxidării mercaptanilor sau a îndepărtării impurităţilor acidice. Constă cu precădere în hidrocarburi saturate şi nesaturate C4. (mt)
C&L Inventory
Petroleumgas (nl)
C&L Inventory
Petroleumgas (sv)
C&L Inventory
Petroleumgaser, flytande, avsvavlad, C4-fraktion (sv)
C&L Inventory
petroleumsgass (no)
C&L Inventory
petroleumsgassser, flytende, søtede (sweetened), C4-fraksjon (no)
C&L Inventory
plin iz predelave zemeljskega olja (sl)
C&L Inventory
plini iz zemeljskega olja, utekočinjeni, sladkani, C4-frakcija (sl)
C&L Inventory
plyn zo spracovania ropy (sk)
C&L Inventory
ropné plyny, skvapalnené, zbavené tiolov, C4-frakcia (sk)
C&L Inventory
Ropné plyny, zkapalněné, slazené, frakce C4; (cs)
C&L Inventory
Ropný plyn (cs)
C&L Inventory
råoliegasser, fortættede, sweetenede, C4-fraktion (da)
C&L Inventory
αέριαΑέρια πετρελαίου, υγροποιημένα, γλυκασμένα, κλάσμα C4 (el)
C&L Inventory
Πετρελαϊκό αέριο (el)
C&L Inventory
Нефтен газ (bg)
C&L Inventory
Нефтени газове, втечнени, сероочистени, С4 фракция (bg)
C&L Inventory
Petroleum gases, liquefied, sweetened, C4 fraction
Other
Petroleum gases, liquefied, sweetened, C4 fraction
C&L Inventory, Registration dossier
Petroleum gases, liquefied, sweetened, c4 fraction
Registration dossier
649-117-00-4
Index number
C&L Inventory
92045-80-2
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 19 studies submitted
  • 8 studies processed
C Physical state at 20°C and 1013 hPa
Gaseous (100%) [8]
C Form
Liquified gas (100%) [7]
C Odour
Other (67%), Odourless (17%), Slight (17%) [6]
C Substance type
Petroleum product (100%) [6]

Type of Study provided
Studies with data
Key study 8
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Gaseous (50%), Liquid (50%)
Form
Gas under pressure: liquefied gas (100%)
Colour
colourless (100%)

Melting/freezing point

Study results
  • 14 studies submitted
  • 11 studies processed
R Melting / freezing point
-187.6 - -105.52 °C @ 101.3 kPa [11]

Type of Study provided
Studies with data
Key study 11
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-153.5 - 5.49 °C

Boiling point

Study results
  • 14 studies submitted
  • 10 studies processed
R Boiling point
-161.48 - 3.71 °C @ 101.3 - 101.325 kPa [10]

Type of Study provided
Studies with data
Key study 10
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
-29.6 - 80.09 °C

Density

Study results
  • 17 studies submitted
  • 11 studies processed
R Density
0.001 - 0.589 g/cm³ @ -162 - 25 °C [6]
R Relative density
0.56 - 0.98 @ 20 - 25 °C [6]

Type of Study provided
Studies with data
Key study 11
Supporting study 5
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.598 - 0.876

Vapour pressure

Study results
  • 11 studies submitted
  • 10 studies processed
R Vapour pressure
100 - 50 400 000 000 000 000 kPa @ -161.7 - 26.85 °C [31]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
99.5 - 8 720 hPa @ 20 - 22 °C

Partition coefficient

Study results
  • 13 studies submitted
  • 13 studies processed
R Log Pow
1.09 - 3.39 @ 20 °C and pH 7 [13]

Type of Study provided
Studies with data
Key study 12 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
2.13 - 2.17 @ 20 °C

Water solubility

Study results
  • 23 studies submitted
  • 6 studies processed
R Water solubility (mass/vol.)
131 - 735 mg/L @ 20 - 25 °C and pH 7 [6]

Type of Study provided
Studies with data
Key study 11
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
186.5 - 1 880 mg/L @ 23.5 - 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 4 studies submitted
  • 3 studies processed
R Flash point
-104 - -60 °C @ 101.3 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
-84 °C

Auto flammability

Study results
  • 15 studies submitted
  • 12 studies processed
R Autoflammability / self-ignition
287 - 537 °C @ 99.8 - 102.1 kPa [12]

Type of Study provided
Studies with data
Key study 12
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
426 °C

Flammability

Study results
  • 15 studies submitted
  • 9 studies processed
C Interpretation of results
Extremely flammable (100%) [9]

Type of Study provided
Studies with data
Key study 11
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Extremely flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 8 studies submitted
  • 8 studies processed
R Dissipation half life (DT50)
5.76 - 45 768 h [8]

Type of Study provided
Studies with data
Key study 3 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
12.5 days

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 22 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence 3 15
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 15
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 16 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 15
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 80 µg/L (1)
Intermittent releases (freshwater) 53 µg/L (1)
Marine water 8 µg/L (1)
Intermittent releases (marine water) 5.3 µg/L (1)
Sewage treatment plant (STP) 39 mg/L (1)
Sediment (freshwater) 1.36 mg/kg sediment dw (1)
Sediment (marine water) 136 µg/kg sediment dw (1)
Hazard for Air
Air Hazard related to composition of atmosphere identified (2)
Hazard for Terrestrial Organism
Soil 225 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 15 studies submitted
  • 15 studies processed
P/RResults
LC50 (4 days) 5.3 - 627.644 mg/L [15]

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 15 studies submitted
  • 1 study processed
P/RResults
NOEC (32 days) 800 µg/L [2]
LOEC (32 days) 1.6 mg/L [2]

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 15 studies submitted
  • 15 studies processed
P/RResults
EC50 (48 h) 10 mg/L [1]
EC50 (24 h) 10 mg/L [1]
LC50 (48 h) 6.971 - 307.472 mg/L [14]

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 15 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 15 studies submitted
  • 15 studies processed
P/RResults
EC50 (4 days) 7.039 - 124.406 mg/L [14]
EC50 (72 h) 32 - 100 mg/L [2]
EC10 (72 h) 10 - 34 mg/L [2]

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DMEL) 2.21 mg/m³ carcinogenicity
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 140 µg/m³ repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DMEL) 464 ng/kg bw/day carcinogenicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
EYE Exposure
Hazard unknown (no further information necessary as no exposure expected)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 8
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 0.1 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
inhalation
  • 21 studies submitted
  • 7 studies processed
P/RResults
LC50 (4 h) 43.767 - 65.4 mg/L air (rat) [2]
LC50 (4 h) 13 700 - 57 000 ppm (rat) [2]
LC50 (15 min) 1 442.738 - 1 443 mg/L air (rat) [2]
LC50 (15 min) 800 000 ppm (rat) [1]
LC50 (2 h) 1 237 mg/L air (mouse) [1]
M/CInterpretations of results
Not classified [7]

inhalation
Studies with data
Key study 7
Supporting study 7
Weight of evidence 4
Other 3
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 22.948 mg/L air
Dermal route:
No adverse effect observed LD50 8 260 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 100 - 148.6 mg/kg bw/day [2]
LOAEL (rat): 25 - 200 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 30 studies submitted
  • 18 studies processed
P/RResults
NOAEC (rat): 96 - 21 394 mg/m³ air [5]
NOAEC (rat): 30 - 16 000 ppm [9]
NOAEC (mouse): 32 - 96 mg/m³ air [2]
NOAEC (mouse): 10 - 10 000 ppm [4]
NOAEC (other:): 0.59 ppm [1]

Study data: inhalation
Studies with data
Key study 24
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed LOAEL 25 mg/kg bw/day (chronic, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 7 214 mg/m³ (chronic, rat)
Inhalation route - local effects:
Adverse effect observed LOAEC 8 600 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 30 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 29
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 15
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
Adverse effect observed (positive)

Carcinogenicity

Study results
  • 22 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 11
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
Adverse effect observed LOAEL 25 mg/kg bw/day (chronic, mouse)
Inhalation route:
No adverse effect observed NOAEC 3 445 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 11
Supporting study 2
Weight of evidence 2
Other 1
Data waiving
no waivers
Study data: developmental
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 17
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
Adverse effect observed NOAEC 5 700 mg/m³ (subchronic, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 5 737 mg/m³ (subchronic, rat)

Neurotoxicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 10 257 mg/m³ (subchronic, rat)

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No summary exists for this scientific endpoint