Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
270-724-1
CAS no.:
68477-33-8
Index number:
649-204-00-7
Molecular formula:
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Organic, Petroleum product
Registered compositions:
9
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01corr) approved by the European Union, this substance may cause genetic defects, may cause cancer and is an extremely flammable gas.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may be fatal if swallowed and enters airways, may damage fertility or the unborn child, is harmful if inhaled, may cause damage to organs through prolonged or repeated exposure, is harmful if swallowed, contains gas under pressure and may explode if heated, causes skin irritation and may cause drowsiness or dizziness.

Breakdown of all 138 C&L notifications submitted to ECHA

Flam. Gas 1 H220 Harmonised Classification
Press. Gas (Liq.) H280
Muta. 1B H340 Harmonised Classification
Repr. 1A H360
Acute Tox. 4 H332
Carc. 1A H350 Harmonised Classification
Carc. 1B H350
STOT RE 2 H373
Asp. Tox. 1 H304
Acute Tox. 4 H302
Skin Irrit. 2 H315
STOT SE 3 H336
Not Classified
Press. Gas Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (65.63% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L).
  • M
There is broad agreement in that a majority of data submitters agree this substance is Mutagenic (65.63% of REACH registrations).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (56.25% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 4 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 to < 1 000 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and manufacturing of the substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

Keep out of reach of children.

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use personal protective equipment as required.; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: In case of leakage eliminate all ignition sources. In case of leaking gas fire do not extinguish unless leak can be stopped safely. If exposed or concerned: get medical advice/attention. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing.

Storage statements

Store this substance protected from sunlight and in a well-ventilated place.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Intertek Deutschland GmbH_UKEO2019, Stangenstr.1 70771 Leinfelden- Echterdingen Germany
  • Polski Koncern Naftowy ORLEN SA, ul. Chemików 7 09-411 Płock Poland
  • SARLUX srl, S.S. Sulcitana 195 km. 19 09018 Sarroch (CA) Sardinia Italy
  • Petroplus Refining and Marketing Limited, Coryton Refinery The Manorway SS17 9LL Stanford-le-Hope Essex United Kingdom
  • Puma Energy Belfast Ltd, Airport Road West Belfast BT3 9EA Belfast United Kingdom (Northern Ireland)

Substance names and other identifiers

[A complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.]
A complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.
C&L Inventory
Gases (petroleum), C3-4, isobutane-rich
EC Inventory, C&L Inventory, REACH pre-registration, Other
Gases (petroleum), C3-4, isobutane-rich
A complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.
C&L Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Gases (petroleum), C3-4, isobutane-rich; Petroleum gas [ complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.]
A complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Gases (petroleum), C3-4, isobutane-rich; Petroleum gas
A complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.
FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes
Gases, petroleum, C3-4, isobutane-rich
A complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.
Other
Isobutane extract
A complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.
Other
Isobutane-rich C3-4 gases (petroleum)
A complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.
Other
Petroleum gas
A complex combination of hydrocarbons from the distillation of saturated and unsaturated hydrocarbons usually ranging in carbon numbers from C3 through C6, predominantly butane and isobutane. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C4, predominantly isobutane.
C&L Inventory
(Keerulise koostisega süsivesinike segu, mis saadakse tavaliselt süsiniku aatomite arvuga C3 kuni C6 küllastunud ja küllastumata süsivesinike, valdavalt butaani ja isobutaani destillatsioonist. Koosneb küllastunud ja küllastumata süsivesinikest süsiniku aatomite arvuga C3 kuni C4, valdavalt isobutaanist.) (et)
C&L Inventory
[Kompleks blanding av hydrokarboner fra destillasjon av mettede og umettede hydrokarboner, vanligvis C3 til C6, hovedsakelig butan og isobutan. Består av mettede og umettede hydrokarboner, C3 til C4, hovedsakelig isobutan.] (no)
C&L Inventory
[Kompleksna kombinacija ogljikovodikov dobljena iz destilacije nasičenih in nenasičenih ogljikovodikov, običajno s številom ogljikovih atomov med C3 in C6, pretežno butan in izobutan. Sestoji iz nasičenih in nenasičenih ogljikovodikov s številom ogljikovih atomov v območju med C3 in C4, pretežno izobutan.] (sl)
C&L Inventory
[komplexe Kombination von Kohlenwasserstoffen, erhalten aus der Destillation gesättigter und ungesättigter Kohlenwasserstoffe mit Kohlenstoffzahlen gewöhnlich im Bereich von C3 bis C6, vorwiegend Butan und Isobutan; besteht aus gesättigten und ungesättigten Kohlenwasserstoffen mit Kohlenstoffzahlen im Bereich von C3 bis C4, vorwiegend Isobutan] (de)
C&L Inventory
[Komplexná zmes uhľovodíkov z destilácie nasýtených a nenasýtených uhľovodíkov, ktoré majú počet atómov uhlíka zvyčajne v rozmedzí od C3 do C6, predovšetkým butánu a izobutánu. Pozostáva z nasýtených a nenasýtených uhľovodíkov s počtom atómov uhlíka prevažne v rozmedzí od C3 do C4, predovšetkým z izobutánu.] (sk)
C&L Inventory
[O combinaţie complexă de hidrocarburi din produsul de distilare al hidrocarburilor saturate şi nesaturate al căror număr de atomi de carbon variază, de obicei, între C3 şi C6, predominând butanul şi izobutanul.] (ro)
C&L Inventory
[Ogļūdeņražu savienojumu komplekss, kas iegūts, destilējot piesātinātus un nepiesātinātus ogļūdeņražus, parasti ar oglekļa atomu skaitu no C3 līdz C6, pārsvarā tie ir butāns un izobutāns. Sastāv no piesātinātiem un nepiesātinātiem ogļūdeņražiem, parasti ar oglekļa atomu skaitu no C3 līdz C4, galvenokārt no izobutāna.] (lv)
C&L Inventory
[Složeni sastav ugljikovodika iz destilacije zasićenih i nezasićenih ugljikovodika obično u području broja ugljikovih atoma C3 do C6, pretežito butan i izobutan. Sastoji se od zasićenih i nezasićenih ugljikovodika s brojem ugljikovih atoma u području C3 do C4, pretežito izobutan.] (hr)
C&L Inventory
[Složitá směs uhlovodíků z destilace nasycených a nenasycených uhlovodíků s počtem uhlíkových atomů obvykle v rozmezí C3 až C6, převážně butanu a isobutanu. Je složena z nasycených a nenasycených uhlovodíků s počtem uhlíkových atomů v rozmezí C3 až C4, převážně isobutanu.] (cs)
C&L Inventory
[Sudėtinis angliavandenilių mišinys, gaunamas distiliuojant sočiuosius ir nesočiuosius angliavandenilius, kurių anglies atomų skaičius paprastai nuo C3 iki C6, daugiausia butaną ir izobutaną. Jį sudaro sotieji ir nesotieji angliavandeniliai, turintys anglies atomų skaičių nuo C3 iki C4, daugiausia izobutanas.] (lt)
C&L Inventory
[Szénhidrogének komplex elegye, melyet C3-C6 szénatomszámú telített és telítetlen szénhidrogének, főleg bután és izobután desztillációjával állítanak elő. Telített és telítetlen szénhidrogénekből (főleg izobutánból) áll, melyek szénatomszáma a C3-C4 tartományban van.] (hu)
C&L Inventory
[Złożona mieszanina węglowodorów z destylacji nasyconych i nienasyconych węglowodorów o liczbie atomów węgla zasadniczo w zakresie od C3 do C6, głównie butanu i izobutanu. Składa się z nasyconych i nienasyconych węglowodorów o liczbie atomów węgla w zakresie C3 do C4, głównie z izobutanu.] (pl)
C&L Inventory
[Πολύπλοκος συνδυασμός υδρογονανθράκων από την απόσταξη κορεσμένων και ακόρεστων υδρογονανθράκων με αριθμό ατόμων άνθρακα που συνήθως κυμαίνεται από C3 έως C6, κυρίως βουτανίου και ισοβουτανίου. Συνίσταται από κορεσμένους και ακόρεστους υδρογονάνθρακες με αριθμό ατόμων άνθρακα μεταξύ C3 και C4, κυρίως ισοβουτάνιο.] (el)
C&L Inventory
[Комплексна комбинация от въглеводороди, получена при дестилация на наситени и ненаситени въглеводороди, обикновено с брой на въглеродните атоми от С3 до С6 включително, основно бутан и изобутан. Състои се от наситени и ненаситени въглеводороди, с брой на въглеродните атоми в интервала от С3 до С4 включително, основно изобутан.] (bg)
C&L Inventory
combinación compleja de hidrocarburos de la destilación de hidrocarburos saturados e insaturados normalmente con un número de carbonos dentro del intervalo de C3 a C6; en su mayor parte butano e isobutano; compuesta de hidrocarburos saturados e insaturados con un número de carbonos dentro del intervalo de C3 a C4; en su mayor parte isobutano (es)
C&L Inventory
Combinaison complexe d'hydrocarbures issue de la distillation d'hydrocarbures saturés et insaturés dont le nombre de carbones varie habituellement de C3 à C6, principalement du butane et de l'isobutane. Se compose d'hydrocarbures saturés et insaturés dont le nombre de carbones se situe dans la gamme C3-4, de l'isobutane en majorité. (fr)
C&L Inventory
Combinazione complessa di idrocarburi ottenuta della distillazione di idrocarburi saturi e insaturi, solitamente con numero di atomi di carbonio nell'intervallo C3-C6, prevalentemente butano e isobutano. È costituita da idrocarburi saturi e insaturi con numero di atomi di carbonio nell'intervallo C3-4, prevalentemente isobutano. (it)
C&L Inventory
Combinação complexa de hidrocarbonetos proveniente da destilação de hidrocarbonetos saturados e insaturados, normalmente com número de átomos de carbono na gama C3 a C6, com predominância de butano e isobutano. É constituída por hidrocarbonetos saturados e insaturados com número de átomos de carbono na gama C3 a C4, com predominância de isobutano. (pt)
C&L Inventory
Dujos (nafta), C3-4, turi daug izobutano (lt)
C&L Inventory
Een complexe verzameling koolwaterstoffen, verkregen door destillatie van verzadigde en onverzadigde koolwaterstoffen, meestal C3 tot en met C6, overwegend butaan en isobutaan. Bestaat uit verzadigde en onverzadigde koolwaterstoffen, C3 tot en met C4, overwegend isobutaan. (nl)
C&L Inventory
En sammensat blanding af carbonhydrider fra destillationen af mættede og umættede carbonhydrider, sædvanligvis C3 til og med C6, overvejende butan og isobutan. Den består af mættede og umættede carbonhydrider, C3 til og med C4, overvejende isobutan. (da)
C&L Inventory
Gaasid (nafta), C3–4, isobutaanirikas (et)
C&L Inventory
gas (petrolio), C3-4, ricchi di isobutano (it)
C&L Inventory
gas di petrolio (it)
C&L Inventory
Gase (Erdöl), C3-4, isobutanreich (de)
C&L Inventory
Gase aus der Erdölverarbeitung (de)
C&L Inventory
Gaser (petroleum), C3-4-, isobutanrika (sv)
C&L Inventory
Gases (petróleo), C3-4, ricos em isobutano (pt)
C&L Inventory
gases (petróleo), C3-4, ricos en isobutano (es)
C&L Inventory
gases de petróleo (es)
C&L Inventory
Gassen (aardolie), C3-4, rijk aan isobutaan (nl)
C&L Inventory
gasser (petroleum), C3-4, isobutanrike (no)
C&L Inventory
gasser (råolie), C3-4-, isobutanrige (da)
C&L Inventory
gaz de pétrole (fr)
C&L Inventory
Gaz en C3-4 (pétrole), riches en isobutane;gaz de pétrole;[Combinaison complexe d'hydrocarbures issue de la distillation d'hydrocarbures saturés ou insaturés comportant habituellement entre 3 et 6 atomes de carbone (C3-C6), principalement du butane et de l'isobutane. Se compose d'hydrocarbures saturés ou insaturés comportant entre 3 et 4 atomes de carbone (C3-C4), principalement de l'isobutane.] (fr)
C&L Inventory
Gaz petrolier (mt)
C&L Inventory
Gaz petrolier (ro)
C&L Inventory
Gaz z ropy naftowej (pl)
C&L Inventory
Gaze (petrol), C3-4, bogate în izobutan (mt)
C&L Inventory
Gaze (petrol), C3-4, bogate în izobutan (ro)
C&L Inventory
Gazy (ropa naftowa), węglowodory C3-4, bogate w izobutan (pl)
C&L Inventory
Gás de petróleo (pt)
C&L Inventory
Gázok (nyersolaj), C3-4, izobutánban gazdag (hu)
C&L Inventory
Gāzes (nafta), C3-4, augsts izobutāna saturs (lv)
C&L Inventory
Kaasut (maaöljy), C3-4, isobutaanirikas (fi)
C&L Inventory
Komplex blandning av kolväten erhållen genom destillation av mättade och omättade kolväten, oftast C3 till C6, främst butan och isobutan. Består av mättade och omättade C3 till C4-kolväten, främst isobutan. (sv)
C&L Inventory
Kulbrintegasser (da)
C&L Inventory
Kőolaj gáz (hu)
C&L Inventory
Maaöljykaasu (fi)
C&L Inventory
Monimutkainen seos hiilivetyjä tyydyttyneiden ja tyydyttymättömien hiilivetyjen, joiden hiililuvut tavallisesti ovat välillä C3:sta C6:een, pääasiassa butaanin ja isobutaanin, tislauksesta. Koostuu tyydyttyneistä ja tyydyttymättömistä hiilivedyistä, joiden hiililuvut ovat välillä C3:sta C4:ään, pääasiassa isobutaanista. (fi)
C&L Inventory
Naftagaas (et)
C&L Inventory
Naftas gāze (lv)
C&L Inventory
Naftni plin (hr)
C&L Inventory
Naftos dujos (lt)
C&L Inventory
O combinaţie complexă de hidrocarburi din produsul de distilare al hidrocarburilor saturate şi nesaturate al căror număr de atomi de carbon variază, de obicei, între C3 şi C6, predominând butanul şi izobutanul. (mt)
C&L Inventory
Petroleumgas (nl)
C&L Inventory
Petroleumgas (sv)
C&L Inventory
petroleumsgass (no)
C&L Inventory
plin iz predelave zemeljskega olja (sl)
C&L Inventory
plini (zemeljsko olje), C3-4, pretežno izobutan (sl)
C&L Inventory
Plinovi (nafta), C3-4, izobutanom bogati (hr)
C&L Inventory
plyn zo spracovania ropy (sk)
C&L Inventory
Plyny (ropné), C3-4, bohaté na isobutan (cs)
C&L Inventory
plyny (ropné), C3-4, s vysokým obsahom izobutánu (sk)
C&L Inventory
Ropný plyn (cs)
C&L Inventory
αέριαΑέρια (πετρελαίου), C3-4, πλούσια σε ισοβουτάνιο (el)
C&L Inventory
Πετρελαϊκό αέριο (el)
C&L Inventory
Газове (нефт), C3-4, богат на изобутан (bg)
C&L Inventory
Нефтен газ (bg)
C&L Inventory
Gases (petroleum), C3-4, isobutane-rich
Other
Gases (petroleum), C3-4, isobutane-rich
C&L Inventory, Registration dossier
Gases (petroleum), C3-4, isobutane-rich
C&L Inventory, Registration dossier
Gases,C3-4,Isobutane rich
Registration dossier
Isobutanemixture
Registration dossier
C4 isomerate
Registration dossier
Isobutane
Registration dossier
649-204-00-7
Index number
C&L Inventory
68477-33-8
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 36 studies submitted
  • 27 studies processed
C Physical state at 20°C and 1013 hPa
Gaseous (100%) [27]
C Form
Liquified gas (96%) [23]
C Odour
Other (50%), Odourless (27%), Slight (9%), Sweetish (9%) [22]
C Substance type
Petroleum product (73%), Organic (27%) [22]

Type of Study provided
Studies with data
Key study 9 18
Supporting study 9
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)
Form
Gas under pressure: liquefied gas (100%)

Melting/freezing point

Study results
  • 16 studies submitted
  • 13 studies processed
R Melting / freezing point
-187.6 - -105.52 °C @ 101.3 kPa [13]

Type of Study provided
Studies with data
Key study 13
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-170 - -154.1 °C

Boiling point

Study results
  • 18 studies submitted
  • 12 studies processed
R Boiling point
-161.48 - 3.71 °C @ 101.3 - 101.325 kPa [12]

Type of Study provided
Studies with data
Key study 13
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
-60.9 - -2.1 °C

Density

Study results
  • 16 studies submitted
  • 11 studies processed
R Density
0.423 - 0.589 g/cm³ @ -162 - 25 °C [10]
R Relative density
0.57 - 0.75 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1 10
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.525 - 0.6

Vapour pressure

Study results
  • 19 studies submitted
  • 4 studies processed
R Vapour pressure
100 - 1 160 kPa @ -7.3 - 25 °C [8]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 12
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
837.25 - 1 666 kPa @ 22 - 25 °C

Partition coefficient

Study results
  • 23 studies submitted
  • 21 studies processed
R Log Pow
0.776 - 2.89 @ 20 °C and pH 7 [21]

Type of Study provided
Studies with data
Key study 1 11 9
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
2.28 - 2.52 @ 20 °C

Water solubility

Study results
  • 21 studies submitted
  • 7 studies processed
R Water solubility (mass/vol.)
24.4 - 792.3 mg/L @ 20 - 25 °C and pH 7 [7]

Type of Study provided
Studies with data
Key study 4 8
Supporting study 9
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Water solubility
51.5 - 371.8 mg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 13 studies submitted
  • 11 studies processed
R Flash point
-104 - -18 °C @ 101.3 kPa [11]

Type of Study provided
Studies with data
Key study 4 7
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
-84 - -26 °C

Auto flammability

Study results
  • 20 studies submitted
  • 16 studies processed
R Autoflammability / self-ignition
287 - 537 °C @ 99.1 - 102.1 kPa [16]

Type of Study provided
Studies with data
Key study 4 12
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
384 - 428 °C

Flammability

Study results
  • 18 studies submitted
  • 12 studies processed
C Interpretation of results
Extremely flammable (100%) [12]

Type of Study provided
Studies with data
Key study 13
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Flammability
Extremely flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 11 studies submitted
  • 11 studies processed
R Dissipation half life (DT50)
3.864 - 45 768 h [13]

Type of Study provided
Studies with data
Key study 7 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half life in air
50.88 h

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 27 studies submitted
  • 20 studies processed
C Interpretation of results
Readily biodegradable (100%) [20]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence 16 7
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 3 studies processed
R H - (pressure) m³/mol
7 150 - 98 200 Pa m³/mol @ 25 °C and 101.3 kPa [6]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
39 840 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No data available: testing technically not feasible (2)
Intermittent releases (freshwater) No data available: testing technically not feasible (2)
Marine water No data available: testing technically not feasible (2)
Intermittent releases (marine water) No data available: testing technically not feasible (2)
Sewage treatment plant (STP) No data available: testing technically not feasible (2)
Sediment (freshwater) No data available: testing technically not feasible (2)
Sediment (marine water) No data available: testing technically not feasible (2)
Hazard for Air
Air Hazard related to composition of atmosphere identified (2)
Hazard for Terrestrial Organism
Soil No data available: testing technically not feasible (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 11 studies submitted
  • 11 studies processed
P/RResults
LC50 (4 days) 24.11 - 147.54 mg/L [10]
LL50 (4 days) 45.7 mg/L [1]

Type of Study provided
Studies with data
Key study 11
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 11 studies submitted
  • 11 studies processed
P/RResults
LC50 (48 h) 14.22 - 69.43 mg/L [10]
LL50 (48 h) 79.51 mg/L [1]

Type of Study provided
Studies with data
Key study 11
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 11 studies submitted
  • 11 studies processed
P/RResults
EC50 (4 days) 7.71 - 16.5 mg/L [10]
EL50 (72 h) 33.6 mg/L [1]

Type of Study provided
Studies with data
Key study 11
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
7.71 - 33.6 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
1 g/L

Sediment toxicity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 5
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 5
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DMEL) 2.21 mg/m³ carcinogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 23.4 mg/kg bw/day carcinogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DMEL) 66.4 µg/m³ carcinogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DMEL) 464 ng/kg bw/day carcinogenicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 26 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 3 9
Supporting study 11
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 0.1 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other
inhalation
  • 41 studies submitted
  • 11 studies processed
P/RResults
LC50 (15 min) 1 442.738 - 1 443 mg/L air (rat) [4]
LC50 (15 min) 800 000 ppm (rat) [2]
LC50 (2 h) 1 237 mg/L air (mouse) [3]
LC50 (2 h) 520 400 - 539 600 ppm (mouse) [5]
M/CInterpretations of results
Not classified [11]

inhalation
Studies with data
Key study 4 7
Supporting study 17
Weight of evidence 10
Other 3
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed LC50 1 443 000 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other 1
Study data: respiratory
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Skin sensitisation
No study available
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 4 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 148.6 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other
Study data: inhalation
  • 45 studies submitted
  • 28 studies processed
P/RResults
NOAEC (rat): 7.214 - 21.394 mg/L air [10]
NOAEC (rat): 4 000 - 16 000 ppm [16]
NOAEC (mouse): 10 000 ppm [4]
LOAEC (rat): 21.641 mg/L air [2]
LOAEC (rat): 5 000 - 12 000 ppm [5]

Study data: inhalation
Studies with data
Key study 10 25
Supporting study 8
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Inhalation route - systemic effects:
No adverse effect observed NOAEC 8 600 mg/m³ (chronic, rat)
Inhalation route - local effects:
Adverse effect observed LOAEC 8 600 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 45 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 12 32
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 9 12
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 23 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 14
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 17 200 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 29 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2 14
Supporting study 2
Weight of evidence 8
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Study data: developmental
  • 24 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3 15
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
Adverse effect observed NOAEC 7 131 mg/m³ (subchronic, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 17 200 mg/m³ (subchronic, rat)

Neurotoxicity

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 11
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant