Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Sodium dodecylbenzenesulfonate
  • IUPAC name:
  • Other names
EC / List no.:
246-680-4
CAS no.:
25155-30-0
Index number:
Molecular formula:
C18H29NaO3S
SMILES:
InChI:
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
6
Of which contain:
8 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in CLP notifications this substance causes serious eye damage, is harmful if swallowed, is harmful in contact with skin, is harmful to aquatic life with long lasting effects, causes skin irritation and may cause respiratory irritation.

Breakdown of all 1914 C&L notifications submitted to ECHA

Acute Tox. 4 H302
Eye Irrit. 2 H319
Skin Irrit. 2 H315
Acute Tox. 4 H312
Eye Dam. 1 H318
STOT SE 3 H335
Aquatic Chronic 3 H412
Not Classified
Aquatic Chronic 2 H411
Acute Tox. 2 H330
Acute Tox. 1 H330
Skin Sens. 1 H317
Acute Tox. 3 H301
Resp. Sens. 1 H334
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
  • Sr

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 9 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 - 10 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: pH regulators and water treatment products, washing & cleaning products, laboratory chemicals, polymers, coating products and metal surface treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, laboratory work and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys) and leather (e.g. gloves, shoes, purses, furniture).

This substance is used in the following products: washing & cleaning products, plant protection products and cosmetics and personal care products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, treatment of articles by dipping and pouring and calendering operations.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use as processing aid.

This substance is used in the following products: washing & cleaning products and leather treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, closed, continuous processes with occasional controlled exposure, mixing in open batch processes, calendering operations, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: washing & cleaning products and cosmetics and personal care products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, laboratory work, mixing in open batch processes, calendering operations and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, calendering operations and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

If medical advice is needed, have product container or label at hand. Keep out of reach of children.

Prevention statements

When handling this substance: wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If swallowed: call a poison center or doctor/physician if you feel unwell. If on skin: wash with soap and water.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ALANCHIM SRL, Via dell'Acero, 16 56022 Castelfranco di Sotto (PI) Italy
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, ROOM 002, REGUS HARCOURT CENTRE D02 HW77 DUBLIN Ireland
  • Koopman International B.V., Distelweg 88 1031 HH Amsterdam Netherlands
  • PERFEKT - SH s.r.o., Hliníková 45 952 01 Vráble Slovakia
  • REACH 2008 Ltd, J.K.Mladost-1, bl.32, fl.5, ap.10 J.K.Mladost-1, bl.32, fl.5, ap.10 1784 Sofia Bulgaria Bulgaria
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • Solvay Solutions Italia S.p.A., Via Milano, 78/80 20021 Ospiate di Bollate (Mi) Italy

Other names

  • -
  • 16456_25155-30-0
  • alkylarylsulphonates
  • Benzenesulfonic acid, dodecyl-, sodium salt
  • Dodecene-1 LAS (JIS K 3363-1990) [for Biodegradability of Synthetic Detergent]
  • Dodecylbenzene sulfonic acid, sodium salt
  • DUBAROL
  • sodium 2-dodecylbenzene-1-sulfonate
  • SODIUM 2-DODECYLBENZENESULFONATE
  • Sodium 4-dodecylbenzenesulfonate
  • Sodium dodecyl benzene sulfonate
  • sodium dodecyl benzenesulfonate
  • sodium dodecylbenzenesufonate
  • SODIUM DODECYLBENZENESULFONATE
  • Sodium Dodecylbenzenesulfonate (Sodium Alkylbenzenesulfonate C10-C13)
  • Sodium dodecylbenzenesulphonate
  • Sodiumdodecylbenzenesulfonate
  • Tetrapropylenbenzenesulfonic acid sodium salt
  • Sodium dodecylbenzenesulfonate
  • Alkyl(C12)benzenesulfonic acid, sodium salt
  • Benzenesulfonic acid, dodecyl-, sodium salt
  • Dodecylbenzene sodium sulfonate
  • dodecylbenzenesulfonic acid, sodium salt;
  • Na-C12 LAS
  • SDBS
  • Sodium Dodecyl Benzene Sulphonate
  • sodium dodecylbenzene sulphonate
  • Sodium laurylbenzenesulfonate
  • sodium linear C12 Alkylbenzene sulfonate

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Powder (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
287.63 °C @ 0 Pa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
287.63 °C

Boiling point

Study results
  • 1 study submitted
  • 1 study processed
R Boiling point
660.62 °C @ 0 Pa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
660.62 °C

Density

Study results
  • 1 study submitted
  • 1 study processed
R Relative density
1 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1

Vapour pressure

Study results
  • 2 studies submitted
  • 2 studies processed
R Vapour pressure
0 Pa @ 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 2 studies processed
R Log Pow
1.96 - 3 @ 25 °C and pH 7 [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
1.96 @ 25 °C

Water solubility

Study results
  • 3 studies submitted
  • 3 studies processed
R Water solubility (mass/vol.)
100 - 800 mg/L @ 25 °C and pH 7 - 9 [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
800 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
30 mN/m @ 120 mg/L

Flash point

Study results
  • 1 study submitted
  • 1 study processed
R Flash point
149 °C @ 101.5 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
149 °C

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

pH

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
0.7 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
0.7

Viscosity

Study results
  • 1 study submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
960 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
960 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 1 study processed
R Degradation rate constant (OH radicals)
0 cm³ molecule-1 d-1 [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
15.84 h
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
1 years @ 50 °C

Phototransformation in water

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in water
2 h

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 3 studies processed
C Interpretation of results
Readily biodegradable (100%) [3]

Type of Study provided
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
23.1 days @ 20 °C

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
70.79 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
70.79 L/kg ww

Adsorption/desorption

Study results
  • 3 studies submitted
  • 1 study processed
R Koc
102.1 L/kg [1]
R log Koc
2.009 L/kg [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
102.1

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
0.006 Pa m³/mol @ 25 °C and 101.325 kPa [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0.006 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 0.644 % [1]
R Water 18.6 % [1]
R Soil 74 % [1]
R Sediment 6.8 % [1]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 693 µg/L (1)
Intermittent releases (freshwater) 654 µg/L (1)
Marine water 1 mg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 50 mg/L (1)
Sediment (freshwater) 27.5 mg/kg sediment dw (1)
Sediment (marine water) 2.75 mg/kg sediment dw (1)
Hazard for Air
Air 10 mg/m³ (1)
Hazard for Terrestrial Organism
Soil 25 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 20 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 11 studies submitted
  • 10 studies processed
P/RResults
LC50 (4 days) 1.67 - 45.883 mg/L [10]
LC50 (24 h) 4.5 - 6.4 mg/L [1]
LC0 (4 days) 4 mg/L [1]
LC100 (4 days) 4.3 mg/L [1]

Type of Study provided
Studies with data
Key study 3 2 1
Supporting study 1
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
6.926 mg/L
LC50 for marine water fish
45.883 mg/L

Long–term toxicity to fish

Study results
  • 8 studies submitted
  • 7 studies processed
P/RResults
NOEC (6.533 months) 630 µg/L [1]
NOEC (3 months) 250 µg/L [1]
NOEC (30 days) 3.965 - 9.198 mg/L [2]
NOEC (28 days) 150 - 3 200 µg/L [4]
LOEC (6.533 months) 1.2 mg/L [1]

Type of Study provided
Studies with data
Key study 2 3
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
3.965 mg/L
EC10 / LC10 or NOEC for marine water fish
9.198 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 11 studies submitted
  • 11 studies processed
P/RResults
EC50 (48 h) 2.5 - 9.5 mg/L [6]
EC50 (24 h) 12 - 17 mg/L [3]
LC50 (4 days) 17.429 mg/L [1]
LC50 (48 h) 1.8 - 23.265 mg/L [5]
LC50 (24 h) 10.7 mg/L [1]

Type of Study provided
Studies with data
Key study 2 2 3
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
6.3 mg/L
EC50 / LC50 for marine invertebrates
4.58 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 7 studies processed
P/RResults
NOEC (30 days) 1.121 - 3.159 mg/L [2]
NOEC (28 days) 2 - 4 mg/L [2]
NOEC (21 days) 1.18 - 3.25 mg/L [4]
NOEC (7 days) 4 mg/L [1]
LOEC (28 days) 4 mg/L [1]

Type of Study provided
Studies with data
Key study 2 2 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
1.65 mg/L
EC10 / LC10 or NOEC for marine invertebrates
1.121 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 4 studies processed
P/RResults
EC50 (4 days) 17.03 - 29 mg/L [3]
EC50 (72 h) 21 - 65.4 mg/L [2]
NOEC (30 days) 7.685 mg/L [1]
NOEC (4 days) 500 µg/L [1]
NOEC (72 h) 7.9 mg/L [1]

Type of Study provided
Studies with data
Key study 1 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
65.4 mg/L
EC50 for marine water algae
6.54 mg/L
EC10 or NOEC for freshwater algae
7.685 mg/L
EC10 or NOEC for marine water algae
770 µg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (7 days) 2.7 mg/L [1]
NOEC (7 days) 900 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater plants
2.7 mg/L
EC50 for marine water plants
270 µg/L
EC10 or NOEC for freshwater plants
900 µg/L
EC10 or NOEC for marine water plants
90 µg/L

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (3 h) 500 - 723 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
500 mg/L
EC10 or NOEC for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
NOEC (28 days) 81 mg/kg sediment dw [1]
NOEC (72 h) 200 mg/kg sediment dw [1]
EC10 (72 h) 275 mg/kg sediment dw [1]
EC50 (28 days) 105 mg/kg sediment dw [1]
LC50 (14 days) 477.471 mg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater sediment
105 mg/kg sediment dw
EC50 / LC50 for marine water sediment
10.5 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
275 mg/kg sediment dw
EC10 / LC10 or NOEC for marine water sediment
27.5 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
NOEC (14 days) 250 - 667 mg/kg soil dw [2]
LC50 (14 days) 1 - 1.333 g/kg soil dw [2]
LC50 (14 days) 477.471 mg/kg soil ww [1]

Type of Study provided
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg soil dw
Long-term EC10 / LC10 / NOEC
250 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC10 (21 days) 85 - 147 mg/kg soil dw [6]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
425 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
85 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 5 studies submitted
  • 4 studies processed
P/RResults
NOEC (5 months) 10 mg/kg soil dw [1]
NOEC (30 days) 7.685 mg/kg soil dw [1]
NOEC (21 days) 100 mg/kg soil dw [1]
EC10 (14 days) 80 - 200 mg/kg soil dw [3]
EC50 (5 months) 100 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1 1 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
100 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
10 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (45 days) 200 mg/kg diet [1]
NOEC (14 days) 2 232 mg/kg diet [1]
LD50 (14 days) 1 356 mg/kg bw/day [1]
NOEL (45 days) 25 mg/kg bw/day [1]
NOEL (14 days) 279 mg/kg bw/day [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg food
Long-term EC10 / LC10 / NOEC
200 mg/kg food

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 52 mg/m³ acute toxicity
Acute /short term: (DNEL) 52 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 52 mg/m³ acute toxicity
Acute /short term: (DNEL) 52 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 57.2 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 80 mg/kg bw/day acute toxicity
Local Effects
Long-term: (DNEL) 1.57 mg/cm² acute toxicity
Acute /short term: (DNEL) 1.57 mg/cm² acute toxicity
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 26 mg/m³ acute toxicity
Acute /short term: (DNEL) 26 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 26 mg/m³ acute toxicity
Acute /short term: (DNEL) 26 mg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 28.6 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 40 mg/kg bw/day acute toxicity
Local Effects
Long-term: (DNEL) 787 µg/cm² acute toxicity
Acute /short term: (DNEL) 787 µg/cm² acute toxicity
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 13 mg/kg bw/day acute toxicity
Acute /short term: (DNEL) 13 mg/kg bw/day acute toxicity
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Dermal: 0.3 %

Acute toxicity

Study results
oral
  • 4 studies submitted
  • 4 studies processed
P/RResults
LD50 500 - 2 000 mg/kg bw (rat) [4]
M/CInterpretations of results
Category 4 based on GHS criteria [3]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (4 h) 310 mg/m³ air (rat) [1]
M/CInterpretations of results
Other [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
LD50 212 - 2 000 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Other [2]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 650 mg/kg bw
Inhalation route:
No adverse effect observed LC50 310 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 7 studies submitted
  • 7 studies processed
P/RResults
NOAEL (rat): 50 - 300 mg/kg bw/day [7]
NOAEL (monkey): 150 mg/kg bw/day [1]
LOAEL (rat): 145 - 200 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 1 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Study data: dermal
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 286 mg/kg bw/day [1]
LOAEL (rat): 286 mg/kg bw/day [1]
LOAEL (guinea pig): 60 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 100 mg/kg bw/day (subacute, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 286 mg/kg bw/day (subacute, rat)
Dermal route - local effects:
No adverse effect observed NOAEL 1.6 mg/cm² (subacute, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 4.35 mg/m³ (subacute, rat)
Inhalation route - local effects:
No adverse effect observed NOAEC 4.35 mg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
Study data: in vivo
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 250 mg/kg bw/day (chronic, rat)
Dermal route:
No adverse effect observed NOAEL 6.25 mg/kg bw/day (chronic, rat)
Inhalation route:
No adverse effect observed NOAEC 10.87 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1 2
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Study data: developmental
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1 7
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 400 mg/kg bw/day (subacute, rat)
Dermal route:
No adverse effect observed NOAEL 10 mg/kg bw/day (subacute, rat)
Inhalation route:
No adverse effect observed NOAEC 17.4 mg/m³ (subacute, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 400 mg/kg bw/day (subacute, rat)
Dermal route:
No adverse effect observed NOAEL 20 mg/kg bw/day (subacute, rat)
Inhalation route:
No adverse effect observed NOAEC 17.4 mg/m³ (subacute, rat)

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant