Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

No image available
EC / List no.:
240-521-2
CAS no.:
16470-24-9
Index number:
Molecular formula:
SMILES:
InChI:
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
20
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the classification provided by companies to ECHA in REACH registrations this substance causes serious eye irritation.

According to the majority of notifications provided by companies to ECHA in CLP notifications no hazards have been classified.

Breakdown of all 346 C&L notifications submitted to ECHA

Not Classified
Eye Irrit. 2 H319
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 23 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: washing & cleaning products, textile treatment products and dyes, coating products and paper chemicals and dyes.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys).

This substance is used in the following products: coating products, textile treatment products and dyes and washing & cleaning products.

This substance is used in the following areas: printing and recorded media reproduction. This substance is used for the manufacture of: textile, leather or fur.

This substance is used in the following activities or processes at workplace: transfer of chemicals, the low energy manipulation of substances bound in materials or articles, treatment of articles by dipping and pouring, transfer of substance into small containers, non-industrial spraying, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, laboratory work and hand mixing with intimate contact only with personal protective equipment available.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following products: textile treatment products and dyes, paper chemicals and dyes, washing & cleaning products and leather treatment products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials and in the production of articles.

This substance is used in the following products: paper chemicals and dyes, textile treatment products and dyes and leather treatment products.

This substance is used for the manufacture of: pulp, paper and paper products, textile, leather or fur and wood and wood products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, treatment of articles by dipping and pouring, transfer of substance into small containers, mixing in open batch processes, calendering operations and roller or brushing applications.

Release to the environment of this substance can occur from industrial use: in the production of articles.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of chemicals at dedicated facilities, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If eye irritation persists get medical advice/attention. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3V Sigma S.p.A, Torquato Tasso 58 24121 Bergamo Italy
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • Colorex S.r.l., via Procche 23 36030 Zugliano Italy
  • DyStar Colours Distribution GmbH, Am Prime-Parc 12 65479 Raunheim Germany
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • IGCAR INDUSTRIES, S.L., c/ Domènech i Montaner, 35-55, Desp 5 08191 Rubí Spain
  • Indulor Leverkusen GmbH & Co. KG, Schulstraße 3 D-49677 Ankum Germany
  • Intertek Deutschland GmbH CSJC, Stangenstr.1 70771 Leinfelden- Echterdingen Germany
  • Intertek Deutschland GmbH CZTW, Stangenstr. 1 70771 Leinfelden-Echterdingen Germany
  • Reach & Colours s.r.o, Thunovská 196/19 Malá Strana 118 00 Prague Czech Republic
  • Reach & Colours Trade Kft, Levente u. 14/a 2161 Csomád Hungary
  • REACH&Colours Kft, Petofi Sandor utca 11 I Em. 4 1052 Budapest Hungary
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP(acts as OR for Zhejiang Hongda Chemicals Co.Ltd), Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • S.A. ROBAMA, Carrer Antic Camí de Tordera, 63-69 PI Mas Puigvert 08389 PALAFOLLS Barcelona Spain
  • SpetsInterProject_Pigment, Näkinkaari 1 M 02320 Espoo Finland
  • Stahl Italy S.r.l., Via A. Manzoni 37 loc. Palazzolo M.se 20037 Paderno Dugnano MI Italy
  • TFM Europe B.V., Van der Takstraat 8 3071 LL Rotterdam Netherlands
  • Archroma Germany GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • Archroma Italy, S.r.l., Via Manzoni 37 20030 Palazzolo Milanese Italy
  • BASF Grenzach GmbH, Köchlinstr. 1 79639 Grenzach-Wyhlen Germany
  • Clariant Produkte (Deutschland) GmbH, August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany
  • Clariant SE - CH77, Brueningstrasse 50 65929 Frankfurt am Main Germany
  • Lambson Limited OR, Clifford House York Road LS22 7NS Wetherby West Yorkshire United Kingdom

Substance names and other identifiers

Tetrasodium 4,4'-bis[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulphonatoanilino)-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate]
EC Inventory, Other
tetrasodium 4,4'-bis[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulphonatoanilino)-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate]
REACH pre-registration, Other
tetrasodium 4,4'-bis{4-[4-(2-hydroxyethylamino)-6-(4-sulfonatoanilino)-1,3,5-triazin-2-ylamino]phenylazo}stilbene-2,2'-disulfonate
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis(5-((4-(bis(2- hydroxyethyl)amino)-6-((4-sulfophenyl)amino)-1,3,5-triazin-2 -yl)amino)-, tetrasodium salt
C&L Inventory
C.I. FB 220/336
Registration dossier
C.I.Flurescent Brighhterner 220
Registration dossier
Enbrite BTM-C
Registration dossier
OB220
Registration dossier
Tetranatrium-4,4'-bis[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulfonatoanilino)-1,3,5-triazin-2-yl]amino] stilben-2,2'-disulfonat]
C&L Inventory
tetrasodium 2,2'-ethene-1,2-diylbis[5-({4-[bis(2-hydroxyethyl)amino]-6-[(4- sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonate]
Registration dossier
tetrasodium 2,2'-ethene-1,2-diylbis[5-({4-[bis(2-hydroxyethyl)amino]-6-[(4-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonate]
C&L Inventory, Registration dossier
tetrasodium 2,2'-ethene-1,2-diylbis[5-({4-[bis(2-hydroxyethyl)amino]-6-[(4-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonate]
Registration dossier
tetrasodium 2-[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulfonatoanilino)-1,3,5-triazin-2-yl]amino]-5-[(E)-2-[4-[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulfonatoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfonatophenyl]ethenyl]benzenesulfonate
C&L Inventory
tetrasodium 4,4'-bis[[4-[bis(2-hydroxyethyl)amino] -6-(4- sulphonatoanilino) -1,3,5-triazin-2-yl]amino]stilbene -2,2'-disulphonate
C&L Inventory
tetrasodium 4,4'-bis[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulphonatoanilino)-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
C&L Inventory
Tetrasodium 4,4'-bis[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulphonatoanilino)-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate]
C&L Inventory, Registration dossier
Tetrasodium 4,4'-bis[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulphonatoanilino)-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate]
C&L Inventory, Registration dossier
tetrasodium 5-[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulfonatoanilino)-1,3, 5-triazin-2-yl]amino]-2-[(E)-2-[4-[[4-[bis(2-hydroxyethyl)amino]-6-(4- sulfonatoanilino)-1,3, 5-triazin-2-yl]amino]-2-sulfonatophenyl]ethenyl]benzenesulfonate
C&L Inventory
tetrasodium 5-[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulfonatoanilino)-1,3,5-triazin-2-yl]amino]-2-[(E)-2-[4-[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulfonatoanilino)-1,3,5-triazin-2-yl]amino]-2-sulfonatophenyl]ethenyl]benzenesulfonate
C&L Inventory
tetrasodium 5-{[(2E)-6-[bis(2-hydroxyethyl)amino]-4-[(4-sulfonatophenyl)amino]-1,2-dihydro-1,3,5-triazin-2-ylidene]amino}-2-[(E)-2-(4-{[(2E)-6-[bis(2-hydroxyethyl)amino]-4-[(4-sulfonatophenyl)amino]-1,2-dihydro-1,3,5-triazin-2-ylidene]amino}-2-sulfonatophenyl)ethenyl]benzene-1-sulfonate
Registration dossier, Other
tetrasodium4,4'-bis[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulphonatoanilino)-1,3,5-triazin-2-yl]
C&L Inventory
C.I.Flurescent Brighhterner 220
Registration dossier
Enbrite BTM-C
Registration dossier
fluoresencent brightening agent 220
Registration dossier
Optical Brightening Agent
Registration dossier
PHOTINE PCP
Registration dossier
115469-16-4
CAS number
Other
153796-51-1
CAS number
Other
16470-24-9
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
1999502-37-2
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 11 studies submitted
  • 7 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [7]
C Form
Powder (71%), Solid: particulate/powder (29%) [7]
C Odour
Other (100%) [2]
C Substance type
Organic (100%) [7]

Type of Study provided
Studies with data
Key study 4
Supporting study 4
Weight of evidence 2 1
Other
Data waiving
no waivers
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: particulate/powder (100%)
Colour
yellow (100%)

Melting/freezing point

Study results
  • 11 studies submitted
  • 5 studies processed
R Melting / freezing point
300 - 400 °C @ 96.945 - 101.3 kPa [5]

Type of Study provided
Studies with data
Key study 5
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 3 summaries processed
Melting / freezing point at 101 325 Pa
300 °C

Boiling point

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 6 studies submitted
  • 4 studies processed
R Bulk density
0.526 g/cm³ @ 27 °C [2]
R Relative density
1.56 @ 22 °C [2]
R Tap density
0.588 g/cm³ @ 27 °C [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Relative density at 20°C
0.526 - 1.56

Vapour pressure

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Vapour pressure
0 - 0 Pa @ 25 °C

Partition coefficient

Study results
  • 7 studies submitted
  • 3 studies processed
R Log Pow
-11.8 - -3.9 @ 25 °C and pH 7 [4]

Type of Study provided
Studies with data
Key study 1 2
Supporting study 2
Weight of evidence 1 1
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Log Kow (Log Pow)
-11.8 - -1 @ 25 °C

Water solubility

Study results
  • 12 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
400 - 650 g/L @ 20 °C and pH 7.9 - 9.34 [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 6 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 4 summaries processed
Water solubility
10 - 650 g/L @ 20 - 26 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 5 studies submitted
  • 2 studies processed
R Surface tension
53.4 - 72.9 mN/m @ 100 - 10 000 mg/L and 20 °C [6]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Surface tension at 20 °C
72 - 72.9 mN/m @ 100 - 1 000 mg/L

Flash point

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
383 °C

Flammability

Study results
  • 7 studies submitted
  • 3 studies processed
C Interpretation of results
Non flammable (100%) [3]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Flammability
Non flammable (60%), Not classified (40%)

Explosiveness

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Oxidising
Non oxidising (50%), No (50%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 6 studies submitted
  • 4 studies processed
C Dissociating properties
Yes (50%), No (50%) [4]
R Dissociation constant
-3 - 4 @ 25 °C [18]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 4
Sci. unjustified
Exposure cons.
Other
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 11 studies submitted
  • 11 studies processed
R Dissipation half life (DT50)
31.2 - 156.6 min [22]

Type of Study provided
Studies with data
Key study 11
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half life in air
31.8 min

Hydrolysis

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 1 summary processed
Half-life for hydrolysis
1 years @ 25 °C

Phototransformation in water

Study results
  • 5 studies submitted
  • 3 studies processed
R Dissipation Half-life (DT50)
4.133 - 556 h [21]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half-life in water
5.033 h

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 34 studies submitted
  • 6 studies processed
R BOD5
5 mg O2/g test material [1]
R COD
1.265 g O2/g test material [1]
R BOD5*100/COD
0.4 mg O2/g test material [1]
C Interpretation of results
Under test conditions no biodegradation observed (100%) [6]

Type of Study provided
Studies with data
Key study 4
Supporting study 13 1
Weight of evidence 4
Other 12
Data waiving
no waivers
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Half-life in freshwater
6 months @ 25 °C
Half-life in freshwater sediment
4.441 years @ 25 °C

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Half-life in soil
12 months @ 25 °C

Bioaccumulation: aquatic / sediment

Study results
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1 4
Weight of evidence 4 2
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
3.162 L/kg ww
Bioaccumulation Factor (BCF) - dimensionless
0.5

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 15 studies submitted
  • 4 studies processed
R Koc
19 952 623.1 - 10 000 000 000 dimensionless @ 25 °C [4]

Type of Study provided
Studies with data
Key study 3
Supporting study 1 2
Weight of evidence 4 2
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Koc at 20°C
4 214 - 10 000

Henrys law constant (H)

Study results
  • 11 studies submitted
  • 11 studies processed
R H - (pressure) m³/mol
0 Pa m³/mol @ 25 °C [11]

Type of Study provided
Studies with data
Key study 11
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 0 % [1]
R Water 100 % [1]
R Soil 0 % [1]
R Sediment 0 % [1]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 4 summaries submitted
  • 4 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 20 - 1 000 µg/L (4)
Intermittent releases (freshwater) 1 - 1.1 mg/L (4)
Marine water 2 - 100 µg/L (4)
Intermittent releases (marine water) 100 µg/L (2)
Sewage treatment plant (STP) 1 - 10 mg/L (4)
Sediment (freshwater) 20.1 - 425 mg/kg sediment dw (4)
Sediment (marine water) 2.01 - 42.5 mg/kg sediment dw (4)
Hazard for Air
Air No hazard identified (3)
Hazard for Terrestrial Organism
Soil 1 - 10 mg/kg soil dw (4)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (3)

Short–term toxicity to fish

Study results
  • 26 studies submitted
  • 10 studies processed
P/RResults
LC50 (4 days) 100 - 1 000 mg/L [8]
LC50 (48 h) 1 g/L [2]
LC0 (4 days) 319 - 1 000 mg/L [3]
LC0 (48 h) 1 g/L [2]
NOEC (4 days) 100 - 185 mg/L [4]

Type of Study provided
Studies with data
Key study 3
Supporting study 6
Weight of evidence 13
Other 4
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 8 studies submitted
  • 3 studies processed
P/RResults
NOEC (34 days) 4.41 - 10.8 mg/L [4]
NOEC (14 days) 859 mg/L [2]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 16 studies submitted
  • 7 studies processed
P/RResults
EC50 (48 h) 100 - 1 000 mg/L [8]
EC0 (48 h) 113 mg/L [1]
EC0 (24 h) 100 mg/L [1]
NOEC (48 h) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 7
Supporting study 9
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 10 studies submitted
  • 7 studies processed
P/RResults
NOEC (21 days) 1 - 31.6 mg/L [11]
LOEC (21 days) 2.53 - 31.6 mg/L [9]
EC10 (21 days) 1.94 - 5.34 mg/L [3]
EC50 (21 days) 1 - 9.32 mg/L [5]
LC50 (21 days) 2.42 - 3.48 mg/L [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 3
Weight of evidence 3
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 17 studies submitted
  • 10 studies processed
P/RResults
EC50 (72 h) 100 - 1 000 mg/L [8]
NOEC (4 days) 500 mg/L [2]
NOEC (72 h) 100 - 120 mg/L [4]
LOEC (4 days) 1 g/L [2]
EC0 (72 h) 500 mg/L [1]

Type of Study provided
Studies with data
Key study 7
Supporting study 5
Weight of evidence 1 1 2
Other 1
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 4 summaries processed
EC50 for freshwater algae
100 - 1 000 mg/L
EC10 or NOEC for freshwater algae
100 - 500 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 19 studies submitted
  • 6 studies processed
P/RResults
EC50 (3 h) 100 mg/L [3]
IC50 (3 h) 100 mg/L [3]

Type of Study provided
Studies with data
Key study 6
Supporting study 11
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 10 studies submitted
  • 1 study processed
P/RResults
NOEC (14 days) 1.37 mg/kg soil dw [1]
LC50 (14 days) 1 g/kg soil dw [1]
LC0 (14 days) 1.37 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence 1 1
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 3
Other
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Short-term EC50 / LC50
3 - 10 g/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 4
Other 1
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 4
Other 1
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 3
Other 1
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.112 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.165 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 722.5 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 416 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 416 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study
Weight of evidence 6 2
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 18 studies submitted
  • 5 studies processed
P/RResults
LD50 5 000 - 10 000 mg/kg bw (rat) [5]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 7
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
dermal
  • 10 studies submitted
  • 4 studies processed
P/RResults
LD50 2 000 - 5 000 mg/kg bw (rat) [4]
M/CInterpretations of results
Practically nontoxic [1]

dermal
Studies with data
Key study 6
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 3 summaries processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 1.895 mg/L air
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 10
Supporting study 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Study data: eye
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 7
Supporting study 5
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 8
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 27 studies submitted
  • 16 studies processed
P/RResults
NOAEL (rat): 200 - 1 000 mg/kg bw/day [23]
NOAEL (rat): 10 000 ppm [4]
LOAEL (rat): 1 000 mg/kg bw/day [1]
NOEL (rat): 1 000 - 10 000 ppm [2]

Type of Study provided
Study data: oral
Studies with data
Key study 9
Supporting study 7 1
Weight of evidence 2 7
Other 1
Data waiving
no waivers
Study data: inhalation
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
M/C Summaries
  • 4 summaries submitted
  • 3 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 250 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 46 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 11 1
Supporting study 6
Weight of evidence 26 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: in vivo
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 11
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 5
Supporting study 5
Weight of evidence 4
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 521 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 4
Supporting study 5
Weight of evidence 1 3
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: developmental
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 5
Supporting study 5 1
Weight of evidence 5
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 3 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 300 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 750 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant