Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Hexaboron dizinc undecaoxide
  • IUPAC name: dizinc(2+) tris(oxo[(oxoboranyl)oxy]borane) dioxidandiide
  • Other names
EC / List no.:
235-804-2
CAS no.:
12767-90-7
Index number:
Molecular formula:
B6O11Zn2
SMILES:
[O--].[O--].[Zn++].[Zn++].O=BOB=O.O=BOB=O.O=BOB=O
InChI:
InChI=1S/3B2O3.2O.2Zn/c3*3-1-5-2-4;;;;/q;;;2*-2;2*+2
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
15
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is very toxic to aquatic life, is toxic to aquatic life with long lasting effects, is suspected of damaging fertility or the unborn child and causes serious eye irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is very toxic to aquatic life with long lasting effects.

Breakdown of all 659 C&L notifications submitted to ECHA

Aquatic Acute 1 H400
Eye Irrit. 2 H319
Repr. 2 H361
Aquatic Chronic 2 H411
Aquatic Chronic 1 H410
STOT SE 3 H335
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 11 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 - 100 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: polymers, lubricants and greases, adhesives and sealants and coating products.

Other release to the environment of this substance is likely to occur from: outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid, of substances in closed systems with minimal release, formulation of mixtures and formulation in materials. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and vehicles. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), metal (e.g. cutlery, pots, toys, jewellery), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), wood (e.g. floors, furniture, toys) and rubber (e.g. tyres, shoes, toys).

This substance is used in the following products: adhesives and sealants, coating products, polymers and fertilisers.

This substance is used in the following areas: agriculture, forestry and fishing, formulation of mixtures and/or re-packaging and building & construction work.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, industrial spraying, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring and hand mixing with intimate contact only with personal protective equipment available.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid, of substances in closed systems with minimal release, formulation of mixtures and formulation in materials. Other release to the environment of this substance is likely to occur from: outdoor use.

This substance is used in the following products: polymers, adhesives and sealants and coating products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, calendering operations, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, the low energy manipulation of substances bound in materials or articles and blowing agents in manufacture of foam.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: polymers, adhesives and sealants and coating products.

This substance is used in the following areas: formulation of mixtures and/or re-packaging and building & construction work.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, treatment of articles by dipping and pouring, industrial spraying, transfer of chemicals at non-dedicated facilities, roller or brushing applications and hand mixing with intimate contact only with personal protective equipment available.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Bootman Chemical Safety Ltd 023, Diss Business Centre IP21 4HD Diss United Kingdom
  • Borax Europe Limited, 6 St. James's Square SW1Y 4AD London United Kingdom
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (SHANDONG BIO INDUSTRY CO., LTD.), Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • EcoChem International nv, Industrielaan 25 2250 Olen Belgium
  • ETIMINE SA, 204, Zone Industrielle Scheleck 2 L-3225 Bettembourg Luxembourg Luxembourg
  • Industrie Bitossi, via Pietramarina, 53 50053 sovigliana-vinci (FI) Italy
  • momaja s.r.o., Karolinska 650/1 186 00 Prague 8 Czech Republic
  • REACH24H CONSULTING GROUP (SHANDONG TAIXING ADVANCED MATERIAL CO., LTD.), Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • Red Orchid Consulting Oy Ltd, Viherkallionkuja 3 I 59 02710 Espoo Finland
  • Rio Tinto Iron & Titanium GmbH (5), Mergenthalerallee 77 65760 Eschborn Hesse Germany
  • SCL ITALIA S.P.A., Via Fabio Filzi 25/A 20124 Milan Italy
  • Joseph Storey & Co. Ltd., Heron Chemical Works Moor Lane LA1 1 QQ Lancaster United Kingdom

Other names

  • -
  • dizinc(2+) ion tris(oxo[(oxoboranyl)oxy]borane) dioxidandiide
  • dizinc(2+) tris(oxo[(oxoboranyl)oxy]borane) dioxidandiide
  • Dodecarbon tetrazinc docosaoxide, heptahydrate
  • Hexaboron dizinc undecaoxide
  • HEXABORON-DIZINC-UNDECAOXIDE-
  • Not applicable
  • Reaction mass of diboron trioxide and zinc oxide and water
  • Zinc Borate
  • zinc;boron;oxygen(2-)
  • Hexaboron dizinc undecaoxide
  • ETI-ZnBor
  • Firebrake 500
  • Firebrake ZB
  • STORFLAM ZB2335
  • ZB2335
  • ZINC BORATE
  • Zinc Borate Hydrate

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Powder (100%) [2]
C Odour
Odourless (100%) [2]
C Substance type
Inorganic (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 2 studies processed
R Melting / freezing point
300 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
2.6

Vapour pressure

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 8 studies submitted
  • 6 studies processed
R Water solubility (mass/vol.)
117 - 25 000 µg/L @ 21.5 °C and pH 6 - 8 [34]

Type of Study provided
Studies with data
Key study 2 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 4 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence 8
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 16 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 6
Weight of evidence 6
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 4 summaries submitted
  • 4 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 20.6 - 2 900 µg/L (4)
Intermittent releases (freshwater) 13.7 mg/L (2)
Marine water 6.1 - 2 900 µg/L (4)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 100 - 10 000 µg/L (4)
Sediment (freshwater) 117.8 mg/kg sediment dw (2)
Sediment (marine water) 56.5 mg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (4)
Hazard for Terrestrial Organism
Soil 5.7 - 35.6 mg/kg soil dw (4)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (4)

Short–term toxicity to fish

Study results
  • 42 studies submitted
  • 14 studies processed
P/RResults
LC50 (4 days) 112 - 79 700 µg/L [38]
LC50 (95 h) 330 µg/L [2]

Type of Study provided
Studies with data
Key study 12
Supporting study
Weight of evidence 4
Other 26
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
79.7 mg/L
LC50 for marine water fish
74 mg/L

Long–term toxicity to fish

Study results
  • 78 studies submitted
  • 46 studies processed
P/RResults
NOEC (2.959 years) 530 µg/L [2]
NOEC (1.808 years) 130 µg/L [2]
NOEC (8 months) 78 - 575 µg/L [8]
NOEC (5 months) 50 - 130 µg/L [4]
NOEC (3.867 months) 56 - 250 µg/L [8]

Type of Study provided
Studies with data
Key study 24
Supporting study 6
Weight of evidence 22
Other 26
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 142 studies submitted
  • 96 studies processed
P/RResults
EC50 (48 h) 155 - 16 200 µg/L [64]
EC50 (24 h) 140 - 27 100 µg/L [66]
LC50 (4 days) 64 - 544 mg/L [30]
LC50 (48 h) 95 - 165 000 µg/L [56]
NOEC (4 days) 103 mg/L [2]

Type of Study provided
Studies with data
Key study 52
Supporting study 16
Weight of evidence 46
Other 28
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 172 studies submitted
  • 132 studies processed
P/RResults
NOEC (9 months) 33.3 - 100 µg/L [4]
NOEC (7 months) 100 µg/L [4]
NOEC (6 months) 100 µg/L [2]
NOEC (3.733 months) 75 µg/L [2]
NOEC (3 months) 300 µg/L [2]

Type of Study provided
Studies with data
Key study 112
Supporting study 2
Weight of evidence 20
Other 38
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 150 studies submitted
  • 46 studies processed
P/RResults
EC50 (72 h) 40.2 - 66 mg/L [8]
IC50 (72 h) 136 - 150 µg/L [4]
NOEC (16 days) 1.071 mg/L [2]
NOEC (10 days) 100 µg/L [2]
NOEC (5 days) 313 µg/L [2]

Type of Study provided
Studies with data
Key study 42
Supporting study
Weight of evidence 4
Other 2 102
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
52.4 mg/L
EC10 or NOEC for freshwater algae
17.5 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 16 studies submitted
  • 4 studies processed
P/RResults
NOEC (10 days) 6.5 mg/L [2]
NOEC (72 h) 60 µg/L [2]
LOEC (10 days) 3.6 - 19.5 mg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 8
Weight of evidence 2
Other 4
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 32 studies submitted
  • 22 studies processed
P/RResults
EC50 (3 h) 5.2 - 10 000 mg/L [8]
IC50 (4 h) 350 µg/L [2]
NOEC (72 h) 10 - 20 mg/L [8]
NOEC (7 h) 100 mg/L [2]
NOEC (4 h) 100 µg/L [2]

Type of Study provided
Studies with data
Key study 2 4
Supporting study 4
Weight of evidence 18
Other 4
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
EC10 or NOEC for microorganisms
100 - 10 000 µg/L

Sediment toxicity

Study results
  • 44 studies submitted
  • 32 studies processed
P/RResults
NOEC (1.055 years) 776 mg/kg sediment dw [2]
NOEC (7 months) 250 mg/kg sediment dw [2]
NOEC (56 days) 850 mg/kg sediment dw [2]
NOEC (42 days) 455 - 1 770 mg/kg sediment dw [10]
NOEC (35 days) 201 - 369 mg/kg sediment dw [4]

Type of Study provided
Studies with data
Key study 20
Supporting study 6
Weight of evidence 14
Other 2 2
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 52 studies submitted
  • 42 studies processed
P/RResults
NOEC (63 days) 19.8 - 78.8 mg/kg soil dw [16]
NOEC (56 days) 5.2 - 600 mg/kg soil dw [24]
NOEC (42 days) 195 - 1 634 mg/kg soil dw [8]
NOEC (28 days) 100 - 1 000 mg/kg soil dw [32]
NOEC (21 days) 85 - 553 mg/kg soil dw [26]

Type of Study provided
Studies with data
Key study 30
Supporting study 6
Weight of evidence 12
Other 4
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 28 studies submitted
  • 24 studies processed
P/RResults
NOEC (42 days) 300 mg/kg soil dw [2]
NOEC (35 days) 21.9 - 175 mg/kg bw [12]
NOEC (28 days) 32 - 1 000 mg/kg soil dw [32]
NOEC (21 days) 174.8 mg/kg soil dw [2]
NOEC (16 days) 98.2 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 16
Supporting study 2
Weight of evidence 8
Other 2
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 72 studies submitted
  • 38 studies processed
P/RResults
NOEC (5 months) 100 - 400 mg/kg soil dw [8]
NOEC (3 months) 10 - 40 mg/kg soil dw [24]
NOEC (70 days) 5 - 10 mg/kg soil dw [4]
NOEC (67 days) 300 mg/kg soil dw [2]
NOEC (60 days) 5 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 24
Supporting study 32
Weight of evidence 16
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 80 studies submitted
  • 76 studies processed
P/RResults
NOEC (6.067 months) 500 mg/kg soil dw [2]
NOEC (84 days) 17 - 200 mg/kg soil dw [10]
NOEC (63 days) 80 mg/kg soil dw [2]
NOEC (55 days) 50 - 150 mg/kg soil dw [8]
NOEC (52 days) 162 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 70
Supporting study 4
Weight of evidence 6
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 22.4 mg/m³ developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 585 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
Local Effects
Long-term: No hazard identified
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8.3 mg/m³ developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 205 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
Local Effects
Long-term: No hazard identified
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.4 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 0.2 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 6 studies submitted
  • 2 studies processed
M/CInterpretations of results
Toxicity Category IV [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 4.95 mg/L air (rat) [2]
M/CInterpretations of results
Practically nontoxic [2]

inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 6 studies submitted
  • 2 studies processed
P/RResults
LD50 5 000 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Study cannot be used for classification [2]

dermal
Studies with data
Key study 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 4.95 mg/m³
Dermal route:
No adverse effect observed LD50 5 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
Study data: eye
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 100 - 375 mg/kg bw/day [4]

Type of Study provided
Study data: oral
Studies with data
Key study 2 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (rat): 3 mg/m³ air [2]

Study data: inhalation
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4
Supporting study 1 1 6
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 1 150 mg/kg bw/day (chronic, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence 4 3
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: developmental
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 100 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant