Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
234-522-7
CAS no.:
12007-92-0
Index number:
Molecular formula:
B5H4NaO10
SMILES:
[Na+].OB1OB(O)O[B-]2(O1)OB(O)OB(O)O2
InChI:
InChI=1S/B5H4O10.Na/c6-1-10-2(7)13-5(12-1)14-3(8)11-4(9)15-5;/h6-9H;/q-1;+1
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
5
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is suspected of damaging fertility or the unborn child.

Breakdown of all 14 C&L notifications submitted to ECHA

Repr. 2 H361
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Nanomaterial form

Substance is known to be on the EEA market in nanomaterial form, as indicated in the REACH registered substance factsheet(s), and as listed in the EUON Nanomaterials in the EU market list.

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 3 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:
Nanomaterials in the EU Market

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, lubricants and greases, washing & cleaning products, anti-freeze products and heat transfer fluids. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and formulation in materials. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), metal (e.g. cutlery, pots, toys, jewellery), wood (e.g. floors, furniture, toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and stone, plaster, cement, glass and ceramic used for large surface area articles (e.g. construction and building materials for floor coverings, isolation articles).

This substance is used in the following products: lubricants and greases, biocides (e.g. disinfectants, pest control products), fertilisers, photo-chemicals and washing & cleaning products.

This substance is used in the following areas: building & construction work, agriculture, forestry and fishing and printing and recorded media reproduction. This substance is used for the manufacture of: fabricated metal products and machinery and vehicles.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals and manual maintenance (cleaning and repair) of machinery.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: pH regulators and water treatment products, lubricants and greases, metal working fluids, adhesives and sealants, fertilisers, laboratory chemicals, photo-chemicals, washing & cleaning products and welding & soldering products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, closed batch processing in synthesis or formulation, mixing in open batch processes and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials and in the production of articles.

This substance is used in the following products: welding & soldering products, laboratory chemicals and lubricants and greases. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: building & construction work. This substance is used for the manufacture of: machinery and vehicles, fabricated metal products, chemicals and metals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers and manual maintenance (cleaning and repair) of machinery.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates) and manufacturing of the substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers, mixing in open batch processes and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Borax Francais S.A.S, 89 Route de Bourbourg CS 70059 59411 Coudekerque-Branche Coudekerque-Branche France
  • Industrie Bitossi, via Pietramarina, 53 50053 sovigliana-vinci (FI) Italy
  • Tillmanns S.p.A., Via B. Crespi 10/A 20159 Milano Italy

Substance names and other identifiers

Agribor
Other
Boron sodium oxide (B5NaO8)
Other
Pentaboron sodium octaoxide
EC Inventory, REACH pre-registration
Pentaboron sodium octaoxide
REACH pre-registration, Other
Sodium Pentaborate
Other
Sodium pentaborate (NaB5O8)
Other
Metabor DF
C&L Inventory
Pentaboron sodium octaoxide
C&L Inventory, Registration dossier
Pentaboron sodium octaoxide, anhydrous
C&L Inventory
Sodium pentaborate
Registration dossier
Sodium pentaborate 2019
Registration dossier
sodium tetrahydroxyspiro[5.5]pentaboroxan-6-uide
Other
Disodium pentaborate decahydrate (Disodium decaborate decahydrate)
Registration dossier
Missibor DF
Registration dossier
Mycrobor DF
Registration dossier
Profibor DF
Registration dossier
12007-92-0
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other
1473420-34-6
CAS number
Other
163751-28-8
CAS number
Other
1800499-96-0
CAS number
Other
39326-63-1
CAS number
Other
933447-02-0
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Crystalline (100%) [1]
C Odour
Odourless (100%) [1]
C Substance type
Inorganic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: crystalline (100%)
Colour
white (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
500 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 1 study submitted
  • 1 study processed
R Density
1.691 g/cm³ @ 20 °C [1]
R Relative density
1 691 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1 691

Vapour pressure

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 1 study submitted
  • 1 study processed
R Water solubility (mass/vol.)
22.1 g/L @ 20 °C and pH 6.57 - 6.75 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
22.1 g/L

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
8.94 @ 20 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
8.94

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 2.9 mg/L (1)
Intermittent releases (freshwater) 13.7 mg/L (1)
Marine water 2.9 mg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 mg/L (1)
Sediment (freshwater) No exposure of sediment expected (1)
Sediment (marine water) No exposure of sediment expected (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 5.7 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 14 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 74 - 79.7 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 12
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 16 studies submitted
  • 11 studies processed
P/RResults
NOEC (34 days) 6.4 mg/L [3]
NOEC (32 days) 11.2 - 44.5 mg/L [2]
LOEC (32 days) 23 mg/L [1]
EC10 (34 days) 6.9 - 18 mg/L [2]
LC10 (34 days) 18.3 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 11
Other 5
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 34 studies submitted
  • 23 studies processed
P/RResults
LC50 (4 days) 64 - 544 mg/L [15]
LC50 (48 h) 91 - 165 mg/L [8]
NOEC (4 days) 103 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 23
Other 11
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 12 studies submitted
  • 10 studies processed
P/RResults
NOEC (42 days) 6.6 - 25.9 mg/L [3]
NOEC (28 days) 16.6 - 43.3 mg/L [12]
NOEC (21 days) 6 - 34.2 mg/L [9]
NOEC (14 days) 13.8 - 14.3 mg/L [6]
NOEC (12 days) 33.1 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 10
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 25 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 40.2 - 66 mg/L [4]
NOEC (72 h) 17.5 - 27.9 mg/L [3]
LOEC (62.4 h) 70.1 mg/L [1]
EC10 (72 h) 24.5 - 50.7 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 23
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
52.4 mg/L
EC10 or NOEC for freshwater algae
17.5 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (10 days) 6.5 mg/L [1]
LOEC (10 days) 3.6 - 19.5 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater plants
11.7 mg/L
EC10 or NOEC for freshwater plants
6.5 mg/L

Toxicity to microorganisms

Study results
  • 9 studies submitted
  • 8 studies processed
P/RResults
EC50 (3 h) 175 - 10 000 mg/L [2]
NOEC (72 h) 10 - 20 mg/L [4]
NOEC (7 h) 100 mg/L [1]
NOEC (3 h) 17.5 - 20 mg/L [2]
LOEC (72 h) 20 - 25 mg/L [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 9
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
10 mg/L

Sediment toxicity

Study results
  • 5 studies submitted
  • 5 studies processed
P/RResults
NOEC (28 days) 37.7 - 201.6 mg/kg sediment dw [9]
NOEC (28 days) 20 - 43 mg/L [5]
NOEC (21 days) 80.6 - 284 mg/kg sediment dw [2]
LOEC (28 days) 37.7 mg/kg sediment dw [1]
LOEC (28 days) 40 - 43 mg/L [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 9 studies submitted
  • 9 studies processed
P/RResults
NOEC (63 days) 19.8 - 78.8 mg/kg soil dw [8]
NOEC (56 days) 5.2 - 98 mg/kg soil dw [10]
NOEC (28 days) 174.8 - 315 mg/kg soil dw [4]
NOEC (14 days) 175 mg/kg soil dw [2]
EC10 (56 days) 70.1 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 9
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 5 studies submitted
  • 4 studies processed
P/RResults
EC10 (28 days) 13.8 - 68.1 mg/kg bw [4]
EC10 (21 days) 47.5 mg/kg soil dw [1]
EC10 (16 days) 22.7 mg/kg soil dw [1]
NOEC (35 days) 21.9 - 175 mg/kg bw [6]
NOEC (21 days) 174.8 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 4
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 23 studies submitted
  • 2 studies processed
P/RResults
NOEC (60 days) 5 mg/kg soil dw [1]
NOEC (21 days) 5.25 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 21
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
NOEC (28 days) 419.6 mg/kg soil dw [1]
EC10 (3.4 months) 15.4 - 17.2 mg/kg soil dw [2]
EC10 (28 days) 3 - 226 mg/kg soil dw [6]
EC50 (3.4 months) 17.5 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 5.5 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 258 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.75 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 9.6 mg/m³ irritation (respiratory tract)
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 129 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 640 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 14
Weight of evidence
Other 1
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 0.5 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 14 studies submitted
  • 3 studies processed
P/RResults
LD50 2 500 - 4 080 mg/kg bw (rat) [4]
M/CInterpretations of results
Other [3]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 5 studies submitted
  • 3 studies processed
P/RResults
LC50 (5 h) 2.03 mg/L air (rat) [1]
LC50 (4 h) 2.04 - 2.12 mg/L air (rat) [2]
M/CInterpretations of results
Other [3]

inhalation
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Other [2]

dermal
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 21 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 17.5 - 100 mg/kg bw/day [2]
LOAEL (rat): 58.5 - 334 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 20
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEC (other:): 57 - 470 mg/m³ air [3]

Study data: inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 66.4 mg/kg bw/day (chronic, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 553.9 mg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 17
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 762.5 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study 8
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3
Supporting study 10
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 66.4 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed BMDL05 39.1 mg/kg bw/day (subacute, rat)

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant