Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
231-599-9
CAS no.:
7647-15-6
Index number:
Molecular formula:
BrNa
SMILES:
[Na+].[Br-]
InChI:
InChI=1S/BrH.Na/h1H;/q;+1/p-1
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
9
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may damage fertility or the unborn child and causes serious eye irritation.

Breakdown of all 711 C&L notifications submitted to ECHA

Repr. 1B H360
Not Classified
Eye Irrit. 2 H319
Aquatic Acute 1 H400
Aquatic Chronic 1 H410
STOT RE 1 H372
Skin Irrit. 2 H315
STOT SE 3 H335
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 15 active registrations under REACH, 1 Joint Submission(s) and 2 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:
There are 0 authorised Biocidal Product(s) that use this substance as an active ingredient

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 - 100 000 tonnes per year.

This substance is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is being reviewed for use as a biocide in the EEA and/or Switzerland, for: disinfection, preservation for liquid systems, controlling slimes.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: pH regulators and water treatment products.

This substance is used in the following areas: mining and formulation of mixtures and/or re-packaging.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: pH regulators and water treatment products, biocides (e.g. disinfectants, pest control products), water treatment chemicals, metals, pharmaceuticals, photo-chemicals and textile treatment products and dyes. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, mixing in open batch processes, transfer of substance into small containers, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, of substances in closed systems with minimal release and in processing aids at industrial sites. Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: pH regulators and water treatment products, biocides (e.g. disinfectants, pest control products), water treatment chemicals, metals, pharmaceuticals, photo-chemicals and textile treatment products and dyes. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: mining, formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, mixing in open batch processes, transfer of substance into small containers, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: of substances in closed systems with minimal release, formulation of mixtures, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, in the production of articles, for thermoplastic manufacture and as processing aid. Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, laboratory work, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, mixing in open batch processes and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; do not get in eyes, on skin, or on clothing.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ALBEMARLE EUROPE SPRL, Parc Scientifique (Einstein) Rue du Bosquet 9 1348 LOUVAIN-LA-NEUVE Belgium
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • Grillo-Werke AG, Weseler Straße 1 47169 Duisburg Germany
  • ICL- IP Terneuzen B.V., Frankrijkweg 6 Havens/Docks 1205-45308 BJ 4538 BJ Terneuzen Netherlands
  • ICL-IP Terneuzen B.V. (M), Frankrijkweg 6, Havens/Docks 1205-45308 BJ 4538 BJ Terneuzen Netherlands
  • ICL-IP Terneuzen B.V. (OR2), Frankrijkweg 6 Havens/Docks 1205-45308 4538 BJ Terneuzen Netherlands
  • Katwijk Chemie BV, Snijderstraat 6 Steenbakkerstraat 26 2222 BA Katwijk ZH Netherlands
  • Laboratorios Miret, S.A., Geminis 4 08228 Terrassa Barcelona Spain
  • LANXESS SOLUTIONS UK LTD, Tenax Road M17 1WT Manchester United Kingdom
  • Merck Santé s.a.s., 37, rue Saint Romain TSA 40123 69379 LYON CEDEX France
  • Schüssler Novachem GmbH, Otto-Stomps-Straße 101 06116 Halle Germany
  • Tetra Technologies (U.K.) Limited, Units 1A & 2A Airport Industrial Estate Howe Moss Drive, Kirkhill Industrial Estate, Dyce AB21 0GL Aberdeen Aberdeenshire United Kingdom
  • UAB "APLINKOS VADYBA", Vilkpėdės g. 22 03151 Vilnius Lithuania
  • Vynova PPC SAS, 95 rue du Général de Gaulle BP 60090 68802 THANN CEDEX France

Substance names and other identifiers

Active bromine generated from sodium bromide and sodium hypochlorite
Biocidal active substances
Sodium bromide
EC Inventory, REACH pre-registration
Sodium bromide (NaBr)
Other
NaBr
Registration dossier
Natriumbromid
Registration dossier
Sodium bromide (dry wt.)
C&L Inventory
Sodiumbromide
Registration dossier
GEOBROM HG 40S
Registration dossier
Natriumbromide
Registration dossier
Sodium bromide 42% solution
Registration dossier
Sodium Bromide 98%
Registration dossier
Sodium Bromide OFA
Registration dossier
Sodium Bromide Technical
Registration dossier
WELLBROM® Sodium Bromide Completion fluid
Registration dossier
59217-63-9
Deleted CAS number
Other
7647-15-6
CAS number
EC Inventory, C&L Inventory, Biocidal active substances, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 6 studies submitted
  • 5 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [5]
C Form
Other (80%), Crystalline (20%) [5]
C Odour
Odourless (100%) [1]
C Substance type
Inorganic (100%) [5]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 7 studies submitted
  • 6 studies processed
R Melting / freezing point
747 - 757.7 °C @ 101.3 - 101.325 kPa [6]

Type of Study provided
Studies with data
Key study 6
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
747 °C

Boiling point

Study results
  • 5 studies submitted
  • 4 studies processed
R Boiling point
1 390 °C @ 101.3 - 101.325 kPa [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Boiling point at 101 325 Pa
1 390 °C

Density

Study results
  • 8 studies submitted
  • 6 studies processed
R Density
3.014 - 3.21 g/cm³ @ 25 °C [5]
R Relative density
3.21 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Relative density at 20°C
3.014

Vapour pressure

Study results
  • 1 study submitted
  • 1 study processed
R Vapour pressure
0 Pa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 4 studies submitted
  • 3 studies processed
R Water solubility (mass/vol.)
909 - 946 g/L @ 25 °C and pH 6.5 - 8 [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Water solubility
909 g/L

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 1 study processed
R pH
5.74 @ 22.5 °C and 430 - 450 g/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
0.23

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 150 µg/L (1)
Intermittent releases (freshwater) 208 µg/L (1)
Marine water 75 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 100 mg/L (1)
Sediment (freshwater) No exposure of sediment expected (1)
Sediment (marine water) No exposure of sediment expected (1)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 3.2 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 3.333 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 14 studies submitted
  • 5 studies processed
P/RResults
LC50 (4 days) 440 - 24 000 mg/L [4]
LC0 (4 days) 7.8 g/L [2]
EC50 (4 days) 44 - 440 mg/L [2]
NOEC (4 days) 25 - 1 000 mg/L [5]

Type of Study provided
Studies with data
Key study 5
Supporting study 8 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
440 - 20 600 mg/L

Long–term toxicity to fish

Study results
  • 17 studies submitted
  • 5 studies processed
P/RResults
NOEC (4.133 months) 7.8 - 78 mg/L [3]
NOEC (3 months) 32 mg/L [1]
NOEC (34 days) 250 - 7 800 mg/L [3]
NOEC (30 days) 10 mg/L [1]
LOEC (4.133 months) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 5
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater fish
10 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 16 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 1 - 5.8 g/L [2]
LC50 (48 h) 6.7 - 11 g/L [2]
LC0 (48 h) 7.8 g/L [1]
NOEC (48 h) 1 - 4.3 g/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 13
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater invertebrates
1 - 6.7 g/L

Long–term toxicity to aquatic invertebrates

Study results
  • 21 studies submitted
  • 6 studies processed
P/RResults
NOEC (23 days) 7.8 - 16 mg/L [2]
NOEC (21 days) 7.5 - 91 mg/L [3]
NOEC (16 days) 2.8 mg/L [2]
LOEC (21 days) 19 mg/L [2]
LOEC (16 days) 5 mg/L [1]

Type of Study provided
Studies with data
Key study 6
Supporting study 15
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater invertebrates
2.8 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 11 studies submitted
  • 3 studies processed
P/RResults
EC50 (4 days) 10 g/L [1]
EC50 (72 h) 8 - 20 000 mg/L [4]
NOEC (4 days) 2.5 g/L [1]
NOEC (72 h) 440 - 2 500 mg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 8
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
8 g/L
EC50 for marine water algae
440 mg/L
EC10 or NOEC for freshwater algae
3.2 g/L

Toxicity to aquatic plants other than algae

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater plants
3.2 g/L

Toxicity to microorganisms

Study results
  • 11 studies submitted
  • 2 studies processed
P/RResults
EC50 (22 h) 5.7 g/L [1]
EC50 (3 h) 1 g/L [1]
NOEC (22 h) 4 g/L [1]
NOEC (3 h) 1 g/L [1]
EC10 (22 h) 3.8 g/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 9
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for microorganisms
1 - 5.7 g/L
EC10 or NOEC for microorganisms
4 g/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (14 days) 10 mg/kg soil dw [1]
EC50 (14 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
100 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 180 - 1 000 mg/kg soil dw [3]
EC50 (21 days) 1 g/kg soil dw [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg soil dw
Long-term EC10 / LC10 / NOEC
180 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (28 days) 1 g/kg soil dw [1]
EC50 (28 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / NOEC
1 g/kg soil dw

Toxicity to birds

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
NOEC (14 days) 292 mg/kg bw [1]
LC50 (21 days) 2 150 mg/kg bw [1]
LC50 (14 days) 2 250 mg/kg bw [1]
LC50 (5 days) 5 633 mg/kg diet [1]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
5.633 g/kg food

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.75 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 95 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 95 mg/kg bw/day repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.66 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 95 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 95 mg/kg bw/day repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 475 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 42 mg/kg bw/day acute toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 59 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 7 2
Supporting study 50
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Dermal: 1 %

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 2 studies processed
P/RResults
LD50 4 200 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
dermal
  • 2 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Not classified [2]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 5 020 mg/kg bw (mouse) [1]

other routes
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 3 500 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 22 studies submitted
  • 5 studies processed
P/RResults
NOAEL (rat): 100 mg/kg bw/day [2]
NOAEL (rat): 300 - 4 800 mg/kg diet [2]
NOAEL (rat): 125 - 1 200 ppm [2]
LOAEL (rat): 100 - 225 mg/kg bw/day [3]
LOAEL (rat): 500 - 4 800 ppm [2]

Type of Study provided
Study data: oral
Studies with data
Key study 5 1
Supporting study 13 3
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 30 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 5 1
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 3 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 6 2
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 90 mg/kg bw/day (chronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 100 mg/kg bw/day (subacute, rat)

Neurotoxicity

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant