Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
  • IUPAC name: calcium 3-hydroxy-4-[(E)-2-(4-methyl-2-sulfophenyl)diazen-1-yl]naphthalene-2-carboxylate
  • Other names
EC / List no.:
226-109-5
CAS no.:
5281-04-9
Index number:
Molecular formula:
C18H12CaN2O6S
SMILES:
[Ca++].CC1=CC(=C(C=C1)\N=N\C1=C(O)C(=CC2=CC=CC=C12)C([O-])=O)S([O-])(=O)=O
InChI:
InChI=1S/C18H14N2O6S.Ca/c1-10-6-7-14(15(8-10)27(24,25)26)19-20-16-12-5-3-2-4-11(12)9-13(17(16)21)18(22)23;/h2-9,21H,1H3,(H,22,23)(H,24,25,26);/q;+2/p-2/b20-19+;
Type of substance:
Mono constituent substance, UVCB
Origin:
Organic
Registered compositions:
29
Of which contain:
2 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.
According to the majority of notifications provided by companies to ECHA in CLP notifications no hazards have been classified.

Breakdown of all 1231 C&L notifications submitted to ECHA

Not Classified
Acute Tox. 4 H332
Aquatic Chronic 3 H412
STOT RE 2 H373
Skin Sens. 1 H317
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • Ss

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 52 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:
Nanomaterials in the EU Market

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 - 100 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: coating products, inks and toners and polymers.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

This substance is used in the following activities or processes at workplace: high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), the low energy manipulation of substances bound in materials or articles and transfer of chemicals at dedicated facilities.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance can be found in complex articles, with no release intended: vehicles, machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and electrical batteries and accumulators. This substance can be found in products with material based on: wood (e.g. floors, furniture, toys), plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), metal (e.g. cutlery, pots, toys, jewellery) and paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).

This substance is used in the following products: inks and toners, coating products, finger paints and polymers.

This substance is used in the following areas: printing and recorded media reproduction and formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: machinery and vehicles and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring, hand mixing with intimate contact only with personal protective equipment available and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

This substance is used in the following products: coating products, inks and toners, polymers and finger paints.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, laboratory work, transfer of substance into small containers and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: inks and toners, coating products, polymers, finger paints, fillers, putties, plasters, modelling clay, paper chemicals and dyes, cosmetics and personal care products and leather treatment products.

This substance is used in the following areas: formulation of mixtures and/or re-packaging, printing and recorded media reproduction and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment. This substance is used for the manufacture of: plastic products and rubber products.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, transfer of chemicals, transfer of substance into small containers, closed batch processing in synthesis or formulation, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, batch processing in synthesis or formulation with opportunity for exposure, roller or brushing applications, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and industrial spraying.

Release to the environment of this substance can occur from industrial use: in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ABACOLOR SRL, via Monte Croce 4/c 35031 Abano Terme Padova Italy
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • BASF Colors & Effects GmbH, An der Rheinschanze 1 67059 Ludwigshafen Germany
  • BASF Colors & Effects Netherlands B.V., Sortieweg 39 6219NT Maastricht Netherlands
  • Brenntag UK Ltd, Redvers Close lawnswood Business Park LS16 6QY Leeds United Kingdom
  • Brilliant Chem Europe GmbH, Muffeter Weg 37 52064 Aachen Germany
  • Chemical Inspection & Regulation Service Limited, Singleton House, Laurence Street Co. Louth Drogheda Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Co. Louth Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL SOLUTIONS LIMITED, 27 Old Gloucester Street WC1N 3AX London United Kingdom
  • Clariant Plastics & Coatings (Deutschland) GmbH, Brüningstrasse 50 65929 Frankfurt am Main Germany
  • Clariant SE - BR01, Am Unisyspark 1 65843 Sulzbach am Taunus Germany
  • COVANCE CRS SA 029, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5-5 Planta 28050 Madrid Spain
  • CSI-OR028, Pentlands Science Park Penicuik EH26 0PZ Edinburgh United Kingdom
  • Daicolor Italy S.R.L., Via Vittor Pisani 28 20124 Milano Italy
  • Daicolorchem EU S.A. - OR - company 002, Pol. Ind. Baix Ebre 165 43897 Campredo Tortosa Spain
  • Daito Kasei Europe, 62 Bld Henri Navier Taverparc 95150 Taverny France
  • DyStar Colours Distribution GmbH, Am Prime-Parc 12 65479 Raunheim Germany
  • EIGENMANN & VERONELLI IBÉRICA, S.L., Polígono Industrial La Pedrosa C/ Miguel Hernández, 42 - 44 Nave A 08908 L’Hospitalet de Llobregat - Barcelona Spain
  • ENVIGO CRS SAU 023, Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain
  • Envigo CRS SAU 032, Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain
  • Flint CPS Inks Germany GmbH, Sieglestrasse 25 70464 Stuttgart Germany
  • Flint CPS Inks Germany GmbH - CN, Sieglestrasse 25 70464 Stuttgart Germany
  • Flint CPS Inks Germany GmbH - NA, Sieglestrasse 25 70464 Stuttgart Germany
  • Gustav Grolman GmbH & Co. KG, Fuggerstr. 1 41468 Neuss Germany
  • Hercules Pigments Pvt Ltd (represented by Luxcontrol S.A.), 1, Avenue des Terres Rouges 4331 Esch sur Alzette Luxembourg
  • Intertek Deutschland GmbH, Stangenstrasse 1 D-70771 Leinfelden-Echterdingen D-70771 Leinfelden-Echterdingen Germany
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany
  • NetSun EU B.V., Blaak 40, Fifth Floor 3011 TA Rotterdam Netherlands
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • Sensient Colors, Oldmedow Road PE30 4LA King's Lynn Norfolk United Kingdom
  • Simpsons UK Ltd, Unit 1,Beacon Business Park, Severnbridge Industrial Estate Caldicot NP26 5PX Caldicot Gwent,South Wales,U.K. United Kingdom
  • Sudarshan Europe B.V., Kingsfordweg 151 1043 GR Amsterdam Noord-Holland Netherlands
  • Sun Chemical A/S, Københavnsvej 112 4600 Køge Denmark
  • Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands
  • Sustainability Support Services (Europe) AB, Markaskälsvägen 6 22647 Lund Sweden
  • Synthesia, a.s., Semtín103 53002 Pardubice Czech Republic
  • Trust Chem Europe B.V., Bergpoortstraat 65 NL-7411 CL Deventer Netherlands
  • UKSEUNG Europe GmbH, Hauptstrasse 14 63860 Rothenbuch Germany
  • Union Colours B.V., ESP 234 5633 AC Eindhoven Netherlands
  • Xerox (Europe) Limited, Ballycoolin Business Park Blanchardstown Dublin 15 Dublin Ireland
  • Xerox Manufacturing (Nederland) BV, Maasheseweg 89-91 5804 AB Venray Limburg Netherlands
  • Zebra A/S, Strandgade 71-73 1401 Copenhagen Denmark
  • [Confidential], [Confidential]
  • BASF plc, Earl Road, P O Box 4 SK8 6QG Cheadle Hulme Cheshire United Kingdom

Other names

  • Bricofor Rubine 4BSP
  • C. I. Pigment 57:1
  • C.I. Pigment Red 57:1
  • C.I. PIGMNET RED 57:1
  • Calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]-2-naphthoate
  • calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2
  • Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
  • calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate; C.I. Pigment Red 57:1;D&C RED 7
  • Calcium 3-hydroxy-4-[(E)-2-(4-methyl-2-sulfonatophenyl)diazen-1-yl]naphthalene-2-carboxylate
  • calcium 3-hydroxy-4-[(E)-2-(4-methyl-2-sulfophenyl)diazen-1-yl]naphthalene-2-carboxylate
  • calcium(4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate
  • D & C Red 7 (Lithol Rubine B, Ca Lake & Lithol Rubine B, Ca Salt)
  • D&C Red No. 7, Unipure Red LC 3079
  • Lithol Rubin BCA
  • Panax Carmine 157, Panax Carmine HF-S(N), Panax Carmine 570W
  • Pigment Red 57
  • Pigment Red 57.1
  • PIGMENT RED 57:1
  • PR57:1
  • Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
  • C.I. 15850:1
  • C.I. Pigment Red 57:1
  • D & C Red 7 (Lithol Rubine B, Ca Lake & Lithol Rubine B, Ca Salt)
  • Neelicert D & C Red 7Lavanya IndicaLithol RubinNeelicet D & C Red 7 Ca LakeLavanya ElegansPIGMENT RED 57:1
  • Pigment Red 57, calcium salt (1:1)
  • PIGMENT RED 57:1
  • PR 57:1
  • SEIKAFAST CARMINE 6B 1476T-7
  • Sudacolor Red 635
  • SYMULER Brilliant Carmine 6B
  • Versal Red 4BP
  • Versalová červeň F6RO/TD-M/4BP
  • Pigment Red 57:1

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 6 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [3]
C Form
Solid: particulate/powder (67%), Powder (33%) [3]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: particulate/powder (100%)
Colour
red (100%)

Melting/freezing point

Study results
  • 8 studies submitted
  • 1 study processed
R Melting / freezing point
400 °C @ 97.69 kPa [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
400 °C

Boiling point

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 5 studies submitted
  • 3 studies processed
R Density
0.352 - 1.7 g/cm³ @ 20 °C [2]
R Relative density
1 700 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Relative density at 20°C
0.352 - 1.7

Vapour pressure

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 2 studies processed
R Log Pow
0.65 @ 23 °C and pH 4.5 - 5 [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Log Kow (Log Pow)
0.65 - 2.4 @ 23 - 25 °C

Water solubility

Study results
  • 8 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
1.2 - 1.3 mg/L @ 23 °C and pH 4.5 - 5 [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Water solubility
8.9 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 3 studies submitted
  • 1 study processed
R Flash point
250 °C @ 97.69 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
250 °C

Auto flammability

Study results
  • 13 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2 1
Supporting study 10
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 15 studies submitted
  • 2 studies processed
C Interpretation of results
GHS criteria not met (100%) [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oxidising
Non oxidising (67%), No (33%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 4 studies submitted
  • 2 studies processed
C Dissociating properties
No (100%) [2]
R Dissociation constant
0.05 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1 1
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
4 months

Biodegradation in water - screening tests

Study results
  • 6 studies submitted
  • 2 studies processed
C Interpretation of results
Not readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 3 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
6.9 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 5 studies submitted
  • 2 studies processed
R Koc
8 321 L/kg @ 25 °C [1]
R log Koc
3.679 dimensionless @ 25 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 1 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Koc at 20°C
8 321

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 30 µg/L (1)
Intermittent releases (freshwater) 330 µg/L (1)
Marine water 3 µg/L (1)
Intermittent releases (marine water) 33 µg/L (1)
Sewage treatment plant (STP) 10 mg/L (1)
Sediment (freshwater) 10 - 25.1 mg/kg sediment dw (2)
Sediment (marine water) 1 - 2.51 mg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 5 - 10 mg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 8 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 100 mg/L [2]
NOEC (4 days) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
LC50 for freshwater fish
33 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 100 mg/L [2]
EC0 (48 h) 50 mg/L [2]
EC100 (48 h) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
280 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
3 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 1 study processed
P/RResults
EC50 (72 h) 190 mg/L [1]
NOEC (72 h) 5.8 mg/L [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
190 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 1 study processed
P/RResults
NOEC (3 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC50 for microorganisms
10 g/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 1 000 mg/kg sediment dw [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.4 mg/m³ repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 570 µg/kg bw/day repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.1 mg/m³ repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 133 µg/kg bw/day repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 600 µg/kg bw/day repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 50 %
Dermal: 50 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 24 studies submitted
  • 8 studies processed
P/RResults
LD50 2 000 - 5 000 mg/kg bw (rat) [6]
LD0 5 000 mg/kg bw (rat) [2]
LD50 4 166.66 - 16 000 mg/kg bw (mouse) [2]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 14 1
Weight of evidence 6
Other
Data waiving
no waivers
inhalation
  • 5 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 h) 1.518 - 4.76 mg/L air (rat) [3]
LC0 (4 h) 1.518 mg/L air (rat) [2]
M/CInterpretations of results
Study cannot be used for classification [1]

inhalation
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 11 studies submitted
  • 5 studies processed
P/RResults
LD50 2 000 - 2 500 mg/kg bw (rat) [5]
LD0 2 500 mg/kg bw (rat) [2]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 2
Supporting study 6
Weight of evidence 3
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed Discriminating conc. 1 518 mg/m³
Dermal route:
No adverse effect observed LD50 2 500 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 39 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study 33
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 33 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study 21
Weight of evidence 7
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 13 studies submitted
  • 2 studies processed
P/RResults
NOEL (rat): 25 - 100 mg/kg bw/day [4]

Type of Study provided
Study data: oral
Studies with data
Key study 3 1 2
Supporting study 6 1
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 3 studies submitted
  • 1 study processed
P/RResults
NOAEL (mouse): 130.6 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 25 mg/kg bw/day (chronic, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 50 mg/kg bw/day (chronic, mouse)

Genetic toxicity

Study results
Study data: in vitro
  • 36 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 12
Supporting study 24
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 2
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 3 2
Supporting study 5 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant