Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
215-154-6
CAS no.:
1307-96-6
Index number:
Molecular formula:
CoO
SMILES:
O=[Co]
InChI:
InChI=1S/Co.O
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
17
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is harmful if swallowed and may cause an allergic skin reaction.

Breakdown of all 445 C&L notifications submitted to ECHA

Aquatic Acute 1 H400 Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
Acute Tox. 4 H302 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (97.56% of REACH registrations).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (97.56% of REACH registrations).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • Sr
There is broad agreement in that a majority of data submitters agree this substance is Respiratory sensitising (99.19% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 30 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 - 10 000 tonnes per year.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting).

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in complex articles, with no release intended: electrical batteries and accumulators and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery).

This substance is used in the following products: coating products.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals at non-dedicated facilities, mixing in open batch processes, roller or brushing applications, non-industrial spraying and hand mixing with intimate contact only with personal protective equipment available.

Other release to the environment of this substance is likely to occur from: outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives) and indoor use.

This substance is used in the following products: pH regulators and water treatment products, coating products and laboratory chemicals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens) and handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders).

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

This substance is used in the following products: laboratory chemicals, pH regulators and water treatment products, semiconductors and coating products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals and electrical, electronic and optical equipment.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders) and the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles, as processing aid and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders), closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and formulation in materials.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; do not breathe the dust, fume, gas, mist, vapours or spray; contaminated work clothing should not be allowed out of the workplace; use only outdoors or in a well-ventilated area; obtain special instructions before use; do not eat, drink or smoke when using this product; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray; wear respiratory protection; in case of inadequate ventilation wear respiratory protection.

Response statements

In case of incident: Wash contaminated clothing before reuse. If skin irritation or a rash occurs: get medical advice/attention. Specific treatment is urgent (see label). If swallowed: immediately call a poison center or doctor/physician. If inhaled: if breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. If exposed or concerned: get medical advice/attention. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. Collect spillage. If experiencing respiratory symptoms: call a poison center or doctor/physician. Immediately call a poison center or doctor/physician. Rinse the mouth. If swallowed: call a poison center or doctor/physician if you feel unwell. If on skin: wash with soap and water. Call a poison center or doctor/physician. Follow specific treatment (see label).

Storage statements

Store this substance locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Advanced Refining Technologies GmbH, In der Hollerhecke 1 67547 Worms Germany
  • ALBEMARLE CATALYSTS COMPANY B.V., Nieuwendammerkade 1-3 PO Box 37650 1030 BE Amsterdam Netherlands
  • AXENS SA, 89, boulevard Franklin Roosevelt B.P. 50802 F-92508 Rueil-Malmaison Cedex France France
  • BASF Nederland B.V., Groningensingel 1 Postbus 1019 6801 MC Arnhem Netherlands
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BCS Only Representative Services Ltd, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • Cambridge Environmental Assessments, part of RSK ADAS Europe (Ireland) Ltd, Office Suite B, Bluebell Business Centre Old Naas Road, Dublin D12 XV7K Dublin Ireland
  • CATALYST RECOVERY EUROPE S.A., 420, Route de Longwy 4832 Rodange Luxembourg
  • Clariant Produkte (Deutschland) GmbH, Am Unisys-Park 1 65843 Sulzbach am Taunus Germany
  • ECO-RIGEN S.R.L., Contrada Piana del Signore c/o Gela Refinery 93012 Gela Italy
  • Eurecat Deutschland GmbH, Tricatstrasse 06803 Bitterfeld-Wolfen Saxonia-Anhalt Germany
  • EURECAT FRANCE SAS, 121 ave Marie Curie ZI Jean Jaurès 07800 La Voulte sur Rhône France
  • Evonik Operations GmbH, Rellinghauser Straße 1 - 11 C-ES 45128 Essen North Rhine-Westfalia Germany
  • GRACE GmbH, In der Hollerhecke 1 67545 Worms Germany
  • GRACE GmbH (OR 4), In der Hollerhecke 1 67547 Worms Germany
  • H.C. Starck Smelting GmbH & Co. KG, Im Schleeke 78 -91 38642 Goslar Germany
  • H.C. Starck Tungsten GmbH, Landsberger Str. 98 80339 München Germany
  • Haldor Topsoe A/S, Nymøllevej 50 DK28000 Lyngby Denmark
  • Hellenic Petroleum S.A., 8Α Chimarras st. GR 15125 Maroussi Attica Greece
  • ITACA, S.A., Partida Rambleta s/n 12191 Pobla Tornesa Castellón Spain
  • Johnson Matthey Chemicals GmbH, Wardstrasse 17 D-46446 Emmerich am Rhein Germany
  • Johnson Matthey PLC, 5th Floor, 25 Farringdon Street EC4A 4AB London United Kingdom
  • Rivendell International, Rivendell House Co. Meath Stamullen Ireland
  • Rivendell International, Rivendell House Co. Meath Stamullen Co. Meath Ireland
  • SAFT AB, Jungnergatan - Box 709 572 28 OSKARSHAMN Sweden
  • Shell Catalyst & Technologies Leuna GmbH, Gebaude 8322 Am Haupttor D-06237 Leuna Leuna Germany
  • SHELL CATALYSTS & TECHNOLOGIES BELGIUM, Pantserschipstraat 331 9000 Gent Belgium
  • TSGE_2019-008, Lavesstraße 4 31137 Hildesheim Germany
  • Umicore NV/SA, Rue du Marais 31 1000 Brussels Belgium
  • UOP B.V.B.A., Noorderlaan 147 B-2030 Antwerp Belgium
  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • Norilsk Nickel Harjavalta Oy (POLAR), Teollisuuskatu 1 FI-29200 Harjavalta Finland

Substance names and other identifiers

Cobalt oxide
EC Inventory, C&L Inventory, REACH pre-registration, EU. Worker Protection-Hazardous (98/24), EU. Dangerous Substances - Eco-Labels, EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
Cobalt(II) oxide
Other
cobaltoxid (da)
C&L Inventory
kobalt-oxid (hu)
C&L Inventory
kobalta oksīds (lv)
C&L Inventory
kobalto oksidas (lt)
C&L Inventory
kobaltov oksid (hr)
C&L Inventory
Kobaltoxid (de)
C&L Inventory
kobaltoxide (nl)
C&L Inventory
koboltoksid (no)
C&L Inventory
koboltoxid (sv)
C&L Inventory
kobolttioksidi (fi)
C&L Inventory
koobaltoksiid (et)
C&L Inventory
ossido di cobalto (it)
C&L Inventory
ossidu tal-kobalt (mt)
C&L Inventory
oxid de cobalt (ro)
C&L Inventory
oxid kobaltnatý (cs)
C&L Inventory
oxyde de cobalt (fr)
C&L Inventory
tlenek kobaltu(II) (pl)
C&L Inventory
óxido de cobalto (es)
C&L Inventory
οξείδιο του κοβαλτίου (el)
C&L Inventory
кобалтов оксид (bg)
C&L Inventory
Cobalt oxide (CoO)
Other
Cobalt (II) oxide powder
C&L Inventory
Cobalt monoxide
C&L Inventory
Cobalt monoxide, Cobalt(II) oxide
Registration dossier
Cobalt(2+) oxide
Registration dossier
N.A.
C&L Inventory
oxocobalt
C&L Inventory, Registration dossier, Other
See section 3.4 for trade name on the mixtures containing the substance
Registration dossier
The substance is only placed on the market as a part of the chemical matrix of an inorganic catalyst (i.e. regarded as a preparation according to Guidance on substance identification). Therefore trade name for the substance does not exist.
Registration dossier
027-002-00-4
Index number
C&L Inventory
1307-96-6
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Dangerous Substances - Eco-Labels, EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
185461-93-2
CAS number
Other
186373-01-3
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [3]
C Form
Powder (100%) [3]
C Substance type
Inorganic (100%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 6 studies processed
R Melting / freezing point
1 830 - 1 935 °C [6]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Melting / freezing point at 101 325 Pa
1 883 °C

Boiling point

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 3 studies submitted
  • 3 studies processed
R Relative density
6.66 @ 21.3 °C [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Relative density at 20°C
6.656

Vapour pressure

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
0 Pa @ 20 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 9 studies submitted
  • 9 studies processed
R Water solubility (mass/vol.)
400 - 32 825 000 ng/L @ 20 - 37 °C and pH 5.85 - 7.76 [54]

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Water solubility
4.88 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 18 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 9
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 6
Exposure cons.
Other 3
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 264 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 108
Supporting study
Weight of evidence
Other 156
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 33 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 30
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 69 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study 3 9
Weight of evidence 12 42
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 4 summaries submitted
  • 4 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 510 - 620 ng/L (4)
Intermittent releases (freshwater) -
Marine water 2.36 µg/L (4)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 370 µg/L (4)
Sediment (freshwater) 9.5 - 53.8 mg/kg sediment dw (4)
Sediment (marine water) 9.5 - 69.8 mg/kg sediment dw (4)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 7.9 - 10.9 mg/kg soil dw (4)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (4)

Short–term toxicity to fish

Study results
  • 73 studies submitted
  • 17 studies processed
P/RResults
LC50 (4 days) 1.512 - 85.3 mg/L [16]
NOEC (4 days) 656.8 - 136 000 µg/L [19]
NOEC (30 min) 89 - 91 µg/L [2]
LOEC (4 days) 1.43 - 88.7 mg/L [16]
LOEC (30 min) 24 - 180 µg/L [3]

Type of Study provided
Studies with data
Key study 15 2
Supporting study 12 9
Weight of evidence 3
Other 24 8
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
LC50 for freshwater fish
1.5 mg/L

Long–term toxicity to fish

Study results
  • 56 studies submitted
  • 18 studies processed
P/RResults
NOEC (81 days) 2.2 mg/L [15]
NOEC (34 days) 210 - 790 µg/L [9]
NOEC (33 days) 1.02 - 2.14 mg/L [9]
NOEC (28 days) 31.196 mg/L [9]
NOEC (7 days) 76.9 - 3 569.6 µg/L [72]

Type of Study provided
Studies with data
Key study 14 4
Supporting study 18 9
Weight of evidence
Other 8 3
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC10 / LC10 or NOEC for freshwater fish
351.4 µg/L
EC10 / LC10 or NOEC for marine water fish
31.802 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 256 studies submitted
  • 86 studies processed
P/RResults
EC50 (4 days) 2.827 mg/L [3]
EC50 (72 h) 2.321 mg/L [3]
EC50 (48 h) 2.618 - 5.89 mg/L [8]
LC50 (7 days) 2.24 - 11.7 mg/L [4]
LC50 (4 days) 3.29 - 429 mg/L [6]

Type of Study provided
Studies with data
Key study 81 5
Supporting study 26 55
Weight of evidence
Other 72 17
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 / LC50 for freshwater invertebrates
610 µg/L
EC50 / LC50 for marine invertebrates
2.32 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 59 studies submitted
  • 37 studies processed
P/RResults
NOEC (3.767 months) 334.3 µg/L [3]
NOEC (42 days) 712.9 µg/L [3]
NOEC (30 days) 16.5 - 684.3 µg/L [24]
NOEC (28 days) 6.83 - 3 730 µg/L [26]
NOEC (21 days) 60.8 - 93.3 µg/L [6]

Type of Study provided
Studies with data
Key study 29 8
Supporting study 12 6
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC10 / LC10 or NOEC for freshwater invertebrates
5.47 - 7.55 µg/L
EC10 / LC10 or NOEC for marine invertebrates
206 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 55 studies submitted
  • 17 studies processed
P/RResults
EC50 (7 days) 24.1 µg/L [3]
EC50 (4 days) 71.314 mg/L [3]
EC50 (72 h) 28.8 - 485.7 µg/L [27]
EC50 (69 h) 80 mg/L [3]
NOEC (7 days) 1.8 µg/L [3]

Type of Study provided
Studies with data
Key study 13 4
Supporting study 10 5
Weight of evidence
Other 16 7
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for freshwater algae
144 - 197 µg/L
EC50 for marine water algae
24.1 µg/L
EC10 or NOEC for freshwater algae
4.9 - 66.9 µg/L
EC10 or NOEC for marine water algae
1.23 µg/L

Toxicity to aquatic plants other than algae

Study results
  • 25 studies submitted
  • 7 studies processed
P/RResults
EC50 (7 days) 19.29 - 565.3 µg/L [27]
NOEC (7 days) 3 - 32.9 µg/L [27]
LOEC (7 days) 8.24 - 67.9 µg/L [27]
EC10 (7 days) 4.79 - 62.17 µg/L [27]
EC20 (7 days) 8.28 - 108.12 µg/L [24]

Type of Study provided
Studies with data
Key study 6 1
Supporting study
Weight of evidence
Other 12 6
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater plants
52 µg/L
EC10 or NOEC for freshwater plants
10.4 µg/L

Toxicity to microorganisms

Study results
  • 16 studies submitted
  • 3 studies processed
P/RResults
EC50 (30 min) 120 mg/L [3]
EC10 (30 min) 3.73 mg/L [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 4 2
Weight of evidence
Other 6 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
120 mg/L
EC10 or NOEC for microorganisms
3.73 mg/L

Sediment toxicity

Study results
  • 37 studies submitted
  • 28 studies processed
P/RResults
NOEC (42 days) 135 - 1 786.7 mg/kg sediment dw [15]
NOEC (42 days) 120 - 240 µg/L [2]
NOEC (35 days) 70.6 - 356 mg/kg sediment dw [2]
NOEC (35 days) 630 - 720 µg/L [2]
NOEC (28 days) 280 - 4 384 mg/kg sediment dw [33]

Type of Study provided
Studies with data
Key study 16 6
Supporting study
Weight of evidence 6
Other 8 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 / LC50 for freshwater sediment
146 - 1 703 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
86 - 698 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 12 studies submitted
  • 12 studies processed
P/RResults
NOEC (42 days) 49 - 1 091 mg/kg soil dw [13]
NOEC (28 days) 88 - 573 mg/kg soil dw [11]
EC10 (42 days) 51.5 - 145.4 mg/kg soil dw [14]
EC10 (28 days) 4.23 - 426 mg/kg soil dw [37]
EC50 (35 days) 1.066 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 12
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
52 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 14 studies submitted
  • 14 studies processed
P/RResults
NOEC (28 days) 52 - 1 000 mg/kg soil dw [16]
EC10 (28 days) 14 - 754 mg/kg soil dw [47]
EC50 (28 days) 297 - 1 066 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 6 8
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
14.3 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 58 studies submitted
  • 54 studies processed
P/RResults
NOEC (21 days) 9 - 379 mg/kg soil dw [32]
NOEC (4 days) 180 mg/kg soil dw [6]
EC10 (22 days) 2.9 - 11.1 mg/kg soil dw [4]
EC10 (21 days) 8 - 617 mg/kg soil dw [157]
EC10 (18 days) 15.4 - 31.6 mg/kg soil dw [6]

Type of Study provided
Studies with data
Key study 3 51
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
2.9 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 16 studies submitted
  • 12 studies processed
P/RResults
NOEC (28 days) 120 mg/kg soil dw [3]
NOEC (7 days) 10 - 5 120 mg/kg soil dw [27]
NOEC (24 h) 80 mg/kg soil dw [3]
EC10 (28 days) 36 - 4 685 mg/kg soil dw [24]
EC10 (7 days) 6 - 4 685 mg/kg soil dw [54]

Type of Study provided
Studies with data
Key study 12
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 1 summary processed
Long-term EC10 / NOEC
5.5 mg/kg soil dw

Toxicity to birds

Study results
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 12
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
Long-term EC10 / LC10 / NOEC
50 mg/kg food

Toxicity to mammals

Study results
  • 8 studies submitted
  • 8 studies processed
P/RResults
NOEC (3.733 months) 200 mg/kg diet [8]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 50.9 µg/m³ repeated dose toxicity
Acute /short term: High hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 8 µg/m³ carcinogenicity
Acute /short term: High hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 12.1 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 111 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 14
Supporting study 87
Weight of evidence
Other 10
Data waiving
no waivers
Study data: dermal absorption
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 4
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 3 studies processed
P/RResults
LD50 159 - 202 mg/kg bw (rat) [9]
M/CInterpretations of results
Toxicity Category III [3]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 6 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 h) 60 - 70 mg/m³ air (rat) [9]
M/CInterpretations of results
Toxicity Category II [3]

inhalation
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 12 studies submitted
  • 9 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [9]
M/CInterpretations of results
Not classified [9]

dermal
Studies with data
Key study
Supporting study
Weight of evidence 9
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oral route:
Adverse effect observed LD50 202 mg/kg bw
Inhalation route:
Adverse effect observed LC50 60 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 51 studies submitted
  • 6 studies processed
P/RResults
NOAEL (rat): 3 - 40 mg/kg bw/day [6]
NOEL (rat): 15 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 6
Weight of evidence 4
Other 39
Data waiving
no waivers
Study data: inhalation
  • 33 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study 26
Weight of evidence
Other 6
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 131 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study
Weight of evidence 112
Other 18
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: in vivo
  • 42 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 3
Weight of evidence 32
Other 4 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 39 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 27 5
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Study data: developmental
  • 37 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 32
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant