Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Hex-1-ene
  • IUPAC name: hex-1-ene
  • Other names
EC / List no.:
209-753-1
CAS no.:
592-41-6
Index number:
Molecular formula:
C6H12
SMILES:
CCCCC=C
InChI:
InChI=1S/C6H12/c1-3-5-6-4-2/h3H,1,4-6H2,2H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
23
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance may be fatal if swallowed and enters airways and is a highly flammable liquid and vapour.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic to aquatic life with long lasting effects, causes serious eye irritation and may cause respiratory irritation.

Breakdown of all 366 C&L notifications submitted to ECHA

Flam. Liq. 2 H225
Asp. Tox. 1 H304
Eye Irrit. 2 H319
Aquatic Chronic 2 H411
STOT SE 3 H335
Skin Irrit. 2 H315
STOT SE 3 H336
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 38 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, lubricants and greases and polishes and waxes.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid, outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring, lubrication at high energy conditions and in partly open process and heat / pressure transfer fluids in closed systems.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, laboratory work, mixing in open batch processes and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, manufacturing of the substance, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, for thermoplastic manufacture, as an intermediate step in further manufacturing of another substance (use of intermediates), manufacturing of the substance, in the production of articles, as processing aid and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: take actions to prevent static discharges; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Do not induce vomiting.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Baker Hughes Ltd, The Ark, 201 Talgarth Road Hammersmith W6 8BJ London United Kingdom
  • Bamberger Polymers (Europe) B.V., Westbroek 45 4822ZX Breda Netherlands
  • BCS Only Representative Services Ltd 016, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • Bemis Valkeakoski Oy, PO Box 70 Teollisuustie 1 37601 Valkeakoski Finland
  • Borealis AG, Wagramerstrasse 17-19 1220 Wien Austria
  • BSM-OR-polymers-Equistar, Delftseplein 27E 3013 AA Rotterdam Netherlands
  • Charles River Laboratories Den Bosch B.V. OR28, Hambakenwetering 7 5231DD 's-Hertogenbosch Netherlands
  • Chevron Phillips Chemicals International N.V. - OR CPC, Airport Plaza, Stockholm Building Da Vincilaan 19 1831 Diegem Belgium
  • Chevron Phillips Chemicals International N.V. - OR SPC, Airport Plaza, Stockholm Bulding Da Vincilaan 19 B - 1831 DIEGEM Belgium
  • Chevron Phillips Chemicals International NV, Airport Plaza, Stockholm Building, Da Vincilaan 19 B-1831 DIEGEM Belgium
  • COVANCE CRS SA 127, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • DOW BENELUX B.V. - OR1, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. - OR2, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-4, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR -30, Postbus 48 4530 AA Terneuzen Netherlands
  • ENVIGO CRS SAU 087, Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain
  • Ineos Feluy SPRL, Parc Industriel de Feluy Nord Zone C B-7181 Feluy Feluy Belgium
  • Ineos Feluy SPRL (OR Joffre), Parc Industriel de Feluy Nord Zone C B-7181 Feluy Belgium
  • Intertek Deutschland GmbH 16, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • INTERTEK FRANCE, ZAC Ecoparc II 27400 HEUDEBOUVILLE France
  • Momentive Performance Materials GmbH, Chempark Building V7 51368 Leverkusen NRW Germany
  • Muntajat B.V, 19th Floor, Tower E, WTC The Hague Prinses Margrietplantsoen 78-A 2595 The Hague Netherlands
  • Muntajat B.V., 19th Floor, Tower E, WTC The Hague Prinses Margrietplantsoen 78-A 2595 The Hague Netherlands
  • Oy Nizhex Scandinavia Ltd, Wavulinintie 10 00210 HELSINKI Finland
  • PETROCHINA INTERNATIONAL (LONDON) CO., LTD, 11th Floor, The Adelphi, 1-11 John Adam Street, WC2N 6HT LONDON United Kingdom
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Netherlands
  • Sasol Chemie GmbH & Co. KG OR NA, Anckelmannsplatz 1 20537 Hamburg Germany
  • Sasol Chemie GmbH & Co. KG OR RSA, Anckelmannsplatz 1 20537 Hamburg Germany
  • Sasol Germany GmbH, Anckelmannsplatz 1 D-20537 Hamburg Germany
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Shell Chemicals Europe B.V., Weena 70 3012 CM Rotterdam Netherlands
  • SI Group UK (UKAA) Ltd, Tenax Road M17 1WT Manchester United Kingdom
  • Specialty Electronic Materials Belgium, BVBA OR-1, Sneeuwbeslaan 20 / Pb10 B-2610 Wilrijk Belgium
  • Total Petrochemicals & Refining SA, Rue de l'Industrie,52 1040 Bruxelles Belgium
  • Total Research & Technology feluy, Zone Industrielle C 7181 Feluy Belgium
  • Tyco Electronics EC Trutnov s.r.o., Komenského 821 Trutnov 54183 Trutnov Czech Republic Czech Republic
  • [Confidential], [Confidential]
  • Shell Chemicals UK Limited, Shell Centre York Road SE1 7NA London London United Kingdom

Other names

  • -
  • 1-Hexen
  • 1-HEXENE
  • 20370_592-41-6
  • Hex-1-ene
  • Hex-1-exe
  • HEXENE
  • Hexene-1
  • Neodene 6 XHP
  • 1-hexene
  • hex-1-ene
  • hexene
  • hexene-1
  • Linealene 6
  • Neodene 6
  • NEODENE 6 XHP
  • NEODENE 6XHP

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 44 studies submitted
  • 38 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (92%), Solid (8%) [38]
C Form
Not specified (81%), Other (13%), Viscous (6%) [31]
C Odour
Other (100%) [23]
C Substance type
Organic (86%), Other (10%) [29]

Type of Study provided
Studies with data
Key study 38
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 25 studies submitted
  • 17 studies processed
R Melting / freezing point
-133 - 68.333 °C @ 101.3 - 101.325 kPa [17]

Type of Study provided
Studies with data
Key study 17
Supporting study 7
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-50 °C

Boiling point

Study results
  • 41 studies submitted
  • 24 studies processed
R Boiling point
60 - 367 °C @ 100.8 - 101.67 kPa [25]

Type of Study provided
Studies with data
Key study 25
Supporting study 2 8
Weight of evidence
Other 6
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
64 °C

Density

Study results
  • 35 studies submitted
  • 22 studies processed
R Density
0.67 - 0.82 g/cm³ @ 20 - 35 °C [22]
R Relative density
0.67 - 0.76 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 27
Supporting study 7
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.674

Vapour pressure

Study results
  • 29 studies submitted
  • 17 studies processed
R Vapour pressure
0.017 - 62 000 Pa @ 20 - 171.111 °C [27]

Type of Study provided
Studies with data
Key study 17
Supporting study 6
Weight of evidence
Other 6
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
24.9 kPa @ 25 °C

Partition coefficient

Study results
  • 75 studies submitted
  • 33 studies processed
R Log Pow
1.5 - 13.96 @ 20 - 25 °C and pH 5.4 - 7 [35]

Type of Study provided
Studies with data
Key study 18 15
Supporting study 28 5
Weight of evidence
Other 9
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
3.87 @ 20 °C

Water solubility

Study results
  • 51 studies submitted
  • 23 studies processed
R Water solubility (mass/vol.)
0 - 88 500 000 ng/L @ 20 - 25 °C and pH 5.5 - 7.46 [25]

Type of Study provided
Studies with data
Key study 13 10
Supporting study 21 2
Weight of evidence
Other 5
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
47 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 35 studies submitted
  • 25 studies processed
R Flash point
-25 - 218 °C @ 99.9 - 101.9 kPa [25]

Type of Study provided
Studies with data
Key study 25
Supporting study 7
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
-25 °C

Auto flammability

Study results
  • 17 studies submitted
  • 9 studies processed
R Autoflammability / self-ignition
222 - 285 °C @ 101.3 - 103.2 kPa [9]

Type of Study provided
Studies with data
Key study 9
Supporting study 5
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
285 °C

Flammability

Study results
  • 7 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 25 studies submitted
  • 16 studies processed
R Other:
0.42 - 6.356 [7]
R dynamic viscosity (in mPa s)
0.202 - 5.04 [6]
R kinematic viscosity (in mm²/s)
0.66 - 19.3 [12]

Type of Study provided
Studies with data
Key study 16
Supporting study 8
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 2 studies processed
R Dissipation half life (DT50)
10.2 h [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 88 studies submitted
  • 31 studies processed
R BOD5
1.64 g O2/g test material [2]
R COD
2.81 g O2/g test material [2]
C Interpretation of results
Readily biodegradable (59%), Not readily biodegradable (31%), Readily biodegradable but failing the 10-day window (10%) [29]

Type of Study provided
Studies with data
Key study 21 19
Supporting study 24 24
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 70 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 18 18
Supporting study 17 17
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 28 studies submitted
  • 24 studies processed
R log Koc
2.59 - 6.63 dimensionless @ 20 °C [24]

Type of Study provided
Studies with data
Key study 1 14 13
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
1 698

Henrys law constant (H)

Study results
  • 24 studies submitted
  • 23 studies processed
R H - (pressure) m³/mol
10 800 - 1 122 150 Pa m³/mol @ 20 - 25 °C and 101.3 kPa [23]

Type of Study provided
Studies with data
Key study 12 12
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Henry's law constant
36 171 Pa.m³.mol-1 @ 20 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 111 µg/L (1)
Intermittent releases (freshwater) 111 µg/L (1)
Marine water 111 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) No hazard identified (1)
Sediment (freshwater) 19.25 mg/kg sediment dw (1)
Sediment (marine water) 19.25 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 4.01 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential to cause toxic effects if accumulated (in higher organisms) via the food chain (1)

Short–term toxicity to fish

Study results
  • 46 studies submitted
  • 12 studies processed
P/RResults
LC50 (4 days) 3.4 - 6 600 µg/L [12]
NOEC (4 days) 3.4 - 2 890 µg/L [6]

Type of Study provided
Studies with data
Key study 12 12
Supporting study 3 11 8
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 48 studies submitted
  • 6 studies processed
P/RResults
EC50 (48 h) 2.8 - 4 400 µg/L [6]
NOEC (48 h) 2.8 - 560 µg/L [4]

Type of Study provided
Studies with data
Key study 9 9
Supporting study 5 15 10
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 19.4 µg/L [2]
LOEC (21 days) 28.7 µg/L [2]
EC50 (21 days) 28.1 µg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 52 studies submitted
  • 6 studies processed
P/RResults
EC50 (4 days) 4.5 - 5.5 mg/L [6]
EC50 (72 h) 930 - 1 800 000 ng/L [4]
NOEC (4 days) 230 - 1 800 µg/L [6]
NOEC (72 h) 930 ng/L [2]

Type of Study provided
Studies with data
Key study 10 10
Supporting study 6 16 10
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 46 studies submitted
  • 20 studies processed
P/RResults
EC50 (3 h) 1 g/L [2]
NOEC (28 days) 2 mg/L [8]
NOEC (14 days) 2 - 17.1 mg/L [6]
NOEC (5 days) 2 - 3 mg/L [4]
NOEC (3 h) 1 g/L [2]

Type of Study provided
Studies with data
Key study 14 14
Supporting study 9 9
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 23 studies submitted
  • 6 studies processed
P/RResults
LC50 (10 days) 182 - 4 780 mg/kg sediment dw [12]

Type of Study provided
Studies with data
Key study 4 4
Supporting study 7 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2 2
Supporting study 6 6
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 46 studies submitted
  • 28 studies processed
P/RResults
LD50 2 000 - 10 000 mg/kg bw (rat) [18]
LD50 5 mL/kg bw (rat) [2]
approx. LD50 10 mL/kg bw (rat) [4]
M/CInterpretations of results
Study cannot be used for classification [2]

Type of Study provided
oral
Studies with data
Key study 15 13
Supporting study 9 9
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 40 studies submitted
  • 26 studies processed
P/RResults
LC50 (6 h) 46.3 mg/L air (rat) [2]
LC50 (4 h) 2.1 mg/L air (rat) [2]
LC50 (4 h) 8 050 ppm (rat) [2]
LC50 (6 h) 46.3 mg/L air (mouse) [2]
LC50 (6 h) 46.3 mg/L air (guinea pig) [2]
M/CInterpretations of results
Other [26]

inhalation
Studies with data
Key study 4 4
Supporting study 7 7
Weight of evidence 9 9
Other
Data waiving
no waivers
dermal
  • 44 studies submitted
  • 24 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [6]
LD50 4 mL/kg bw (rat) [2]
approx. LD50 2 - 4 mL/kg bw (rat) [2]
LD50 2 000 - 10 000 mg/kg bw (rabbit) [6]
LD50 2 mL/kg bw (rabbit) [2]
M/CInterpretations of results
Category 5 based on GHS criteria [4]

dermal
Studies with data
Key study 12 12
Supporting study 10 10
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study 7 7
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 74 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 16 16
Supporting study 20 22
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 54 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 18 16
Supporting study 10 10
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 31 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 14 14
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 79 studies submitted
  • 18 studies processed
P/RResults
NOAEL (rat): 500 - 1 000 mg/kg bw/day [9]
NOEL (rat): 20 - 1 000 mg/kg bw/day [15]
LOEL (rat): 20 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 6 12
Supporting study 21 39
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: inhalation
  • 8 studies submitted
  • 2 studies processed
P/RResults
NOAEC (rat): 3 000 ppm [2]

Study data: inhalation
Studies with data
Key study 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: dermal
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 2 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 60 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 26 26
Supporting study 4 4
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 6 4
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 32 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1 2
Supporting study 8 16
Weight of evidence
Other 5
Data waiving
no waivers
Study data: developmental
  • 47 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1 2
Supporting study 13 26
Weight of evidence
Other 5
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 300 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 6 6
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant