Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
208-909-6
CAS no.:
546-68-9
Index number:
Molecular formula:
C12H28O4Ti
SMILES:
[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-]
InChI:
InChI=1S/4C3H7O.Ti/c4*1-3(2)4;/h4*3H,1-2H3;/q4*-1;+4
Type of substance:
Mono constituent substance
Origin:
Organic, Organometallic
Registered compositions:
14
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the classification provided by companies to ECHA in REACH registrations this substance causes serious eye irritation, is a flammable liquid and vapour, is a flammable solid and may cause drowsiness or dizziness.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic if inhaled and causes serious eye damage.

Breakdown of all 1259 C&L notifications submitted to ECHA

Flam. Liq. 3 H226
Eye Irrit. 2 H319
Eye Dam. 1 H318
STOT SE 3 H336
Acute Tox. 3 H331
Skin Irrit. 2 H315
Not Classified
Asp. Tox. 1 H304
STOT RE 1 H372
Aquatic Chronic 2 H411
STOT SE 3 H335
Flam. Sol. 2 H228
Eye Irrit. 2A H319
Acute Tox. 4 H332
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 20 active registrations under REACH, 2 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers.

This substance is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: water treatment chemicals, pH regulators and water treatment products and laboratory chemicals.

This substance is used in the following areas: health services and scientific research and development. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: adhesives and sealants, coating products and lubricants and greases.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of substance into small containers and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers, fuels, coating products and lubricants and greases. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: health services and scientific research and development. This substance is used for the manufacture of: chemicals and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: ground and bond container and receiving equipment; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use explosion-proof equipment (electrical/ventilating/lighting/etc.); wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If eye irritation persists get medical advice/attention.

Storage statements

Store this substance in a well-ventilated place and Keeping it cool.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Borica Europe BVBA, Elzenstraat 31 3950 Bocholt Belgium
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre HW77 D02 Dublin Ireland
  • Connect Chemicals (UK) Ltd., Winnington Hall Cheshire CW8 4DU Northwich United Kingdom
  • Connect Chemicals GmbH, Kokkolastr. 2 40882 Ratingen Germany
  • Connect Chemicals Italia S.r.l., Via Torri Bianche, 9 20871 Vimercate (MB) Italy
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW CHEMICAL IBERICA S.L., Ribera del Loira 4-6 Edificio Iris, 4º Planta 28042 Madrid Spain
  • DOW OLEFINVERBUND GMBH, Strasse B 13 D-06258 Schkopau Germany
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • GRACE Catalyst AB, Industrivägen 44432 Stenungsund Sweden
  • GRACE GmbH, In der Hollerhecke 1 67545 Worms Germany
  • Merck Performance Materials GmbH, Rheingaustrasse 190-196 65203 Wiesbaden Germany
  • MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany
  • Nisso Chemical Europe GmbH, Berliner Allee 42 40212 Düsseldorf Germany
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • SAFC HiTech Ltd., The Old Brickyard, New Road SP8 4XT Gillingham, Dorset United Kingdom
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • UNION QUIMICO FARMACÉUTICA S.A., Mallorca 262 08008 Barcelona Barcelona Spain
  • Johnson Matthey PLC, 5th Floor, 25 Farringdon Street EC4A 4AB London United Kingdom

Substance names and other identifiers

Titanium tetraisopropanolate
EC Inventory, REACH pre-registration
2-Propanol, titanium(4+) salt (4:1)
Other
2-Propanol, titanium(4+) salt
C&L Inventory, Registration dossier
isopropyltitanate
C&L Inventory
propan-2-ol; titanium
C&L Inventory
propan-2-olate; titanium(4+)
C&L Inventory
propan-2-olate;titanium(4+)
C&L Inventory, Registration dossier
Tetraisopropyl Orthotitanate
C&L Inventory
Tetraisopropyl orthotitanate, Titanium(IV) isopropoxide
Registration dossier
TETRAISOPROPYL TITANATE
C&L Inventory, Registration dossier
TIPT
Registration dossier
Titanium isopropoxide
C&L Inventory
titanium tetraisopropanolato
Registration dossier
Titanium tetrakis(propan-2-olato)
C&L Inventory, Registration dossier
titanium(4+) ion tetrakis(propan-2-olate)
Registration dossier
titanium(4+) tetrakis(propan-2-olate)
C&L Inventory, Other
Titanium(IV) isopropoxide
C&L Inventory
Titanium(IV) propan-2-olate
C&L Inventory
Titantetraisopropanolat
C&L Inventory
Tyzor TPT
C&L Inventory
Insocat 138
Registration dossier
TETRAISOPROPYL TITANATE, 51% IN HEPTANE
Registration dossier
Tytan TIPT
Registration dossier
TYZOR® TPT
Registration dossier
Tyzor®TPT
Registration dossier
VERTEC AC213
Registration dossier
VERTEC AC470
Registration dossier
VERTEC AC715
Registration dossier
VERTEC TIPT
Registration dossier
VERTEC VEXP0589
Registration dossier
VERTEC XL110
Registration dossier
VERTEC XL206
Registration dossier
1004522-95-5
Deleted CAS number
Other
1016644-08-8
Deleted CAS number
Other
112797-74-7
Deleted CAS number
Other
1149373-13-6
Deleted CAS number
Other
118815-04-6
Deleted CAS number
Other
119651-13-7
Deleted CAS number
Other
1245903-59-6
Deleted CAS number
Other
128796-34-9
Deleted CAS number
Other
131530-94-4
Deleted CAS number
Other
1352612-45-3
Deleted CAS number
Other
147809-57-2
Deleted CAS number
Other
167709-32-2
Deleted CAS number
Other
176680-01-6
Deleted CAS number
Other
186518-71-8
Deleted CAS number
Other
187601-75-8
Deleted CAS number
Other
195382-13-9
Deleted CAS number
Other
198699-88-6
Deleted CAS number
Other
210407-18-4
Deleted CAS number
Other
216859-04-0
Deleted CAS number
Other
244173-55-5
Deleted CAS number
Other
245654-31-3
Deleted CAS number
Other
255839-65-7
Deleted CAS number
Other
259264-35-2
Deleted CAS number
Other
300564-30-1
Deleted CAS number
Other
310882-94-1
Deleted CAS number
Other
347859-73-8
Deleted CAS number
Other
3651-85-2
Deleted CAS number
Other
366477-01-2
Deleted CAS number
Other
408306-55-8
Deleted CAS number
Other
50336-56-6
Deleted CAS number
Other
505093-57-2
Deleted CAS number
Other
518050-49-2
Deleted CAS number
Other
546-68-9
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other
71515-81-6
Deleted CAS number
Other
73264-97-8
Deleted CAS number
Other
917485-01-9
Deleted CAS number
Other
918419-31-5
Deleted CAS number
Other
94340-28-0
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 2 studies processed
R Melting / freezing point
-4 - 18.5 °C @ 101.1 kPa [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-4 °C

Boiling point

Study results
  • 9 studies submitted
  • 5 studies processed
R Boiling point
82.3 - 240 °C @ 100.67 - 101.3 kPa [5]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1 6
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
82.3 - 220 °C

Density

Study results
  • 8 studies submitted
  • 2 studies processed
R Relative density
0.954 - 0.96 @ 25 °C [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.96 - 0.971

Vapour pressure

Study results
  • 4 studies submitted
  • 3 studies processed
R Vapour pressure
1.33 - 60.2 hPa @ 25 - 63.2 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
60.2 hPa @ 25 °C

Partition coefficient

Study results
  • 4 studies submitted
  • 2 studies processed
R Pow
1.13 @ 25 °C [1]
R Log Pow
0.05 @ 25 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
0.05

Water solubility

Study results
  • 5 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
1 000 g/L @ 25 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
1 000 g/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 5 studies submitted
  • 2 studies processed
R Flash point
41 - 47 °C @ 101.325 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
41 °C

Auto flammability

Study results
  • 3 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
400 °C @ 100.576 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
400 °C

Flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 3 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
3 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
3 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
3 min @ 10 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 5 studies submitted
  • 3 studies processed
C Interpretation of results
Readily biodegradable (100%) [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
1.53

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 590 µg/L (1)
Intermittent releases (freshwater) 5.9 mg/L (1)
Marine water 59 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 105 mg/L (1)
Sediment (freshwater) 482 µg/kg sediment dw (1)
Sediment (marine water) 48.2 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 112 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 4.2 - 11.13 g/L [4]
LC50 (72 h) 11.13 g/L [1]
LC50 (48 h) 4.9 - 11.13 g/L [2]
LC50 (24 h) 7.1 - 11.16 g/L [2]
LC50 (60 min) 11.83 g/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
4.2 g/L

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 590 - 700 mg/L [4]
EC50 (24 h) 770 - 910 mg/L [4]
NOEC (24 h) 440 - 520 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
590 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 400 - 960 mg/L [8]
NOEC (72 h) 50 - 237 mg/L [4]
LOEC (72 h) 97 - 115 mg/L [2]
EC10 (72 h) 71 - 300 mg/L [4]
EC20 (72 h) 130 - 530 mg/L [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
820 mg/L
EC10 or NOEC for freshwater algae
201 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
1.05 g/L

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 mg/m³ -
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 7 studies submitted
  • 5 studies processed
P/RResults
LD50 5 800 - 7 500 mg/kg bw (rat) [3]
LD50 4 475 mg/kg bw (mouse) [1]
LD50 7 990 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Practically nontoxic [4]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence 2 3
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 2 studies processed
P/RResults
LC50 (6 h) 10 000 ppm (rat) [1]
LC50 (4 h) 7.78 mg/L air (rat) [1]
M/CInterpretations of results
Moderately toxic [1]

inhalation
Studies with data
Key study
Supporting study 1
Weight of evidence 1 1
Other
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 12 870 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Practically nontoxic [1]

dermal
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 7 500 mg/kg bw
Inhalation route:
Adverse effect observed LC50 7 780 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence 5 1
Other
Data waiving
no waivers
Study data: eye
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence 6
Other
Data waiving
Not feasible
Sci. unjustified 5
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route - systemic effects:
No adverse effect observed NOAEC 12 300 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 1
Supporting study 1
Weight of evidence 2 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant